Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

The success of long-term electrophysiological recordings often depends on the quality of the implantation surgery. Here we provide useful information for surgeons who are learning the process of implanting electrode systems. We demonstrate the implantation procedure of both a penetrating and a surface electrode. The surgical process is described from start to finish, including detailed descriptions of each step throughout the procedure. It should also be noted that this video guide is focused towards procedures conducted in rodent models and other small animal models. Modifications of the described procedures are feasible for other animal models.

[1]  G. Paxinos,et al.  Comprar The Mouse Brain in Stereotaxic Coordinates, The coronal plates and diagrams Compact, 3rd Edition | Keith Franklin | 9780123742445 | Academic Press , 2008 .

[2]  G. Buzsáki,et al.  Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex , 2008, Nature Neuroscience.

[3]  Kip A Ludwig,et al.  Naïve coadaptive cortical control , 2005, Journal of neural engineering.

[4]  Daniel R. Merrill,et al.  Electrical stimulation of excitable tissue: design of efficacious and safe protocols , 2005, Journal of Neuroscience Methods.

[5]  R A Normann,et al.  The Utah intracortical Electrode Array: a recording structure for potential brain-computer interfaces. , 1997, Electroencephalography and clinical neurophysiology.

[6]  Justin C. Williams,et al.  Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex , 2004, IEEE Transactions on Biomedical Engineering.

[7]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[8]  Daryl R Kipke,et al.  Development of Closed-Loop Neural Interface Technology in a Rat Model: Combining Motor Cortex Operant Conditioning With Visual Cortex Microstimulation , 2010, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[9]  R. J. Vetter,et al.  Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex , 2003, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[10]  L. Swanson The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5 , 1984 .