Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects.

[1]  Nikolay Bazhanov,et al.  Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties , 2010, Proceedings of the National Academy of Sciences.

[2]  J. K. Leach,et al.  Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels , 2016, Stem cells translational medicine.

[3]  Petros Koumoutsakos,et al.  TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. , 2009, BioTechniques.

[4]  Marcel Karperien,et al.  Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration. , 2017, Tissue engineering. Part B, Reviews.

[5]  Y. Zhong,et al.  Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction. , 2017, Biomaterials.

[6]  R. Zhao,et al.  Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. , 2008, Cell stem cell.

[7]  Jason A. Burdick,et al.  Local nascent protein deposition and remodeling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels , 2019, Nature Materials.

[8]  G. Duda,et al.  Immunology Guides Skeletal Muscle Regeneration , 2018, International journal of molecular sciences.

[9]  Haibin Zhou,et al.  Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function. , 2016, Journal of bioscience and bioengineering.

[10]  J. K. Leach,et al.  Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels. , 2014, Acta biomaterialia.

[11]  L. Bian,et al.  Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/β-catenin signaling. , 2017, Biomaterials.

[12]  Robert B West,et al.  Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments , 2018, Nature Communications.

[13]  FollinBjarke,et al.  Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture. , 2016 .

[14]  V. Han,et al.  The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche , 2017, Stem cells international.

[15]  Gareth Williams,et al.  Dimeric Versions of Two Short N-cadherin Binding Motifs (HAVDI and INPISG) Function as N-cadherin Agonists* , 2002, The Journal of Biological Chemistry.

[16]  M. Arruebo,et al.  Topographical cues regulate the crosstalk between MSCs and macrophages , 2015, Biomaterials.

[17]  G. Duda,et al.  Cell therapy to improve regeneration of skeletal muscle injuries , 2019, Journal of cachexia, sarcopenia and muscle.

[18]  S. Allan,et al.  Changes in the secretome of tri-dimensional spheroid-cultured human mesenchymal stem cells in vitro by interleukin-1 priming , 2018, Stem Cell Research & Therapy.

[19]  J. Burdick,et al.  Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments , 2018, Nature Communications.

[20]  D J Mooney,et al.  Alginate hydrogels as synthetic extracellular matrix materials. , 1999, Biomaterials.

[21]  A. Boccaccini,et al.  Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. , 2006, Biomaterials.

[22]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[23]  H. Tse,et al.  Mesenchymal stem cells and immunomodulation: current status and future prospects , 2016, Cell Death and Disease.

[24]  Yunlong Liu,et al.  Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression. , 2015, American journal of physiology. Heart and circulatory physiology.

[25]  Brian D Cosgrove,et al.  N-Cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells , 2016, Nature materials.

[26]  Ovijit Chaudhuri,et al.  Maintenance of Neural Progenitor Cell Stemness in 3D Hydrogels Requires Matrix Remodeling , 2017, Nature materials.

[27]  L. Bian,et al.  Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells. , 2018, Biomaterials.

[28]  David J. Mooney,et al.  Designing hydrogels for controlled drug delivery. , 2016, Nature reviews. Materials.

[29]  L. Bian,et al.  Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis , 2013, Proceedings of the National Academy of Sciences.

[30]  J. Burdick,et al.  Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials , 2017, ACS biomaterials science & engineering.

[31]  J. Frith,et al.  Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect. , 2017, Stem cells and development.

[32]  Liming Bian,et al.  Adaptable Hydrogels Mediate Cofactor‐Assisted Activation of Biomarker‐Responsive Drug Delivery via Positive Feedback for Enhanced Tissue Regeneration , 2018, Advanced science.

[33]  Meghna S Motwani,et al.  Author Correction: Bi-directional cell-pericellular matrix interactions direct stem cell fate , 2018, Nature Communications.

[34]  O. Blaschuk,et al.  A Novel Family of Cyclic Peptide Antagonists Suggests That N-cadherin Specificity Is Determined by Amino Acids That Flank the HAV Motif* , 2000, The Journal of Biological Chemistry.

[35]  Zoe Cesarz,et al.  Spheroid Culture of Mesenchymal Stem Cells , 2015, Stem cells international.

[36]  J. Burdick,et al.  Dose and Timing of N‐Cadherin Mimetic Peptides Regulate MSC Chondrogenesis within Hydrogels , 2018, Advanced healthcare materials.

[37]  C. Meisel,et al.  Immunomodulatory placental‐expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty , 2018, Journal of cachexia, sarcopenia and muscle.

[38]  D. Mooney,et al.  Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration. , 2016, Biomaterials.

[39]  D. Ding,et al.  Composite Hydrogel Modified by IGF-1C Domain Improves Stem Cell Therapy for Limb Ischemia. , 2018, ACS applied materials & interfaces.

[40]  James C. Weaver,et al.  Substrate stress relaxation regulates cell spreading , 2015, Nature Communications.

[41]  S. Andreadis,et al.  CDH2 and CDH11 act as regulators of stem cell fate decisions. , 2015, Stem cell research.

[42]  D. Mooney,et al.  Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs. , 2017, Biomaterials.

[43]  Todd C McDevitt,et al.  Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion. , 2014, Cytotherapy.

[44]  Qiang Zhao,et al.  IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI. , 2016, Journal of the American Society of Nephrology : JASN.