Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Title Lack of Support for the Association Between GAD 2 Polymorphisms and Severe Human Obesity Permalink

[1]  Claude Bouchard,et al.  The Human Obesity Gene Map: The 2005 Update , 2006, Obesity research.

[2]  Mark Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[3]  M. Imperiale,et al.  Adeno-associated viral glutamate decarboxylase expression in the lateral nucleus of the rat hypothalamus reduces feeding behavior , 2004, Gene Therapy.

[4]  J. Flier.  Obesity Wars Molecular Progress Confronts an Expanding Epidemic , 2004, Cell.

[5]  K. Clément,et al.  GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity , 2003, PLoS biology.

[6]  D. Allison,et al.  Nonreplication in genetic association studies of obesity and diabetes research. , 2003, The Journal of nutrition.

[7]  F. Dudbridge.  Pedigree disequilibrium tests for multilocus haplotypes , 2003, Genetic epidemiology.

[8]  S. O’Rahilly,et al.  Minireview: human obesity-lessons from monogenic disorders. , 2003, Endocrinology.

[9]  C. Vaisse,et al.  Emerging trends in the search for genetic variants predisposing to human obesity , 2003, Current opinion in clinical nutrition and metabolic care.

[10]  L. Cardon,et al.  Population stratification and spurious allelic association , 2003, The Lancet.

[11]  J. Hebebrand,et al.  Genome scan for childhood and adolescent obesity in German families. , 2003, Pediatrics.

[12]  Pak Chung Sham,et al.  Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits , 2003, Bioinform..

[13]  C. Saper,et al.  The Need to Feed Homeostatic and Hedonic Control of Eating , 2002, Neuron.

[14]  Laura Kettel Khan,et al.  Trends and correlates of class 3 obesity in the United States from 1990 through 2000. , 2002, JAMA.

[15]  K. Flegal,et al.  Prevalence and trends in obesity among US adults, 1999-2000. , 2002, JAMA.

[16]  David Altshuler,et al.  Once and again-issues surrounding replication in genetic association studies. , 2002, The Journal of clinical endocrinology and metabolism.

[17]  Celeste Eng,et al.  Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. , 2002, The Journal of clinical investigation.

[18]  J. Hirschhorn,et al.  A comprehensive review of genetic association studies , 2002, Genetics in Medicine.

[19]  J. Ioannidis,et al.  Replication validity of genetic association studies , 2001, Nature Genetics.

[20]  I. Day,et al.  An efficient procedure for genotyping single nucleotide polymorphisms. , 2001, Nucleic acids research.

[21]  M. Collin,et al.  GABAergic Nature of Hypothalamic Leptin Target Neurones in the Ventromedial Arcuate Nucleus , 2001, Journal of neuroendocrinology.

[22]  M. Low,et al.  Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus , 2001, Nature.

[23]  R. A. Price,et al.  A locus affecting obesity in human chromosome region 10p12 , 2001, Diabetologia.

[24]  L. Cardon,et al.  Association study designs for complex diseases , 2001, Nature Reviews Genetics.

[25]  J. Hebebrand,et al.  Independent confirmation of a major locus for obesity on chromosome 10. , 2000, The Journal of clinical endocrinology and metabolism.

[26]  E. Martin,et al.  A test for linkage and association in general pedigrees: the pedigree disequilibrium test. , 2000, American journal of human genetics.

[27]  Gregory S. Barsh,et al.  Genetics of body-weight regulation , 2000, Nature.

[28]  P. Kopelman.  Obesity as a medical problem , 2000, Nature.

[29]  G. Colditz,et al.  The disease burden associated with overweight and obesity. , 1999, JAMA.

[30]  M. Thun,et al.  Body-mass index and mortality in a prospective cohort of U.S. adults. , 1999, The New England journal of medicine.

[31]  P. Kwok,et al.  Fluorescence polarization in homogeneous nucleic acid analysis. , 1999, Genome research.

[32]  T. Horvath,et al.  Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. , 1999, Endocrinology.

[33]  Freely associating , 1999, Nature Genetics.

[34]  K. Clément,et al.  A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10 , 1998, Nature Genetics.

[35]  Ronald M. Krauss,et al.  American Heart Association Call to Action: Obesity as a Major Risk Factor for Coronary Heart Disease , 1998 .

[36]  A. Grüters,et al.  Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans , 1998, Nature Genetics.

[37]  K. Clément,et al.  A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction , 1998, Nature.

[38]  A. Strosberg,et al.  A leptin missense mutation associated with hypogonadism and morbid obesity , 1998, Nature Genetics.

[39]  M. Ichikawa,et al.  Effect of injection of antisense oligodeoxynucleotides of GAD isozymes into rat ventromedial hypothalamus on food intake and locomotor activity , 1998, Brain Research.

[40]  W. Ewens,et al.  A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. , 1998, American journal of human genetics.

[41]  R. Krauss,et al.  American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. , 1998, Circulation.

[42]  D. Hanahan,et al.  Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. Hebebrand,et al.  Absence of leptin deficiency mutation in extremely obese German children and adolescents , 1997, International Journal of Obesity.

[44]  S. O’Rahilly,et al.  Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene , 1997, Nature Genetics.

[45]  M. Neale,et al.  Genetic and Environmental Factors in Relative Body Weight and Human Adiposity , 1997, Behavior genetics.

[46]  S. O’Rahilly,et al.  Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.

[47]  Weiqun,et al.  Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity. , 1995, The Journal of clinical investigation.

[48]  M. Schwartz,et al.  Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase , 1993, Brain Research Bulletin.

[49]  A. K. Rattan,et al.  Electrical activity and feeding correlates of intracranial hypothalamic injection of GABA, muscimol and picrotoxin in the rats. , 1990, Acta neurobiologiae experimentalis.

[50]  W. Schaffner,et al.  Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. , 1989, Nucleic acids research.

[51]  A. Stunkard,et al.  A twin study of human obesity. , 1986, JAMA.

[52]  S. Leibowitz.  Brain monoamines and peptides: role in the control of eating behavior. , 1986, Federation proceedings.