Preclinical Development of Bortezomib (VELCADE
暂无分享,去创建一个
[1] D. Neuberg,et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. , 2002, Cancer research.
[2] A. Arlt,et al. Autocrine Production of Interleukin 1β Confers Constitutive Nuclear Factor κB Activity and Chemoresistance in Pancreatic Carcinoma Cell Lines , 2002 .
[3] J. Adams. Development of the proteasome inhibitor PS-341. , 2002, The oncologist.
[4] R. Meyn,et al. Protease inhibitors restore radiation‐induced apoptosis to Bcl‐2‐expressing lymphoma cells , 2001, International journal of cancer.
[5] Ulrich Siebenlist,et al. Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells , 2001, The Journal of experimental medicine.
[6] P. Richardson,et al. Novel therapies targeting the myeloma cell and its bone marrow microenvironment. , 2001, Seminars in oncology.
[7] J. Berenson,et al. The role of nuclear factor-?b in the biology and treatment of multiple myeloma , 2001 .
[8] D. Howard,et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. , 2001, Blood.
[9] H. Withers,et al. Molecular Pathways That Modify Tumor Radiation Response , 2001, American journal of clinical oncology.
[10] R. Bold,et al. Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. , 2001, The Journal of surgical research.
[11] A. Hunter,et al. Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an ∼700 kDa Apaf-1 containing apoptosome complex , 2001, Leukemia.
[12] Wei Ping Wang,et al. Inhibition of proteasome function induced apoptosis in gastric cancer , 2001 .
[13] P. Richardson,et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. , 2001, Blood.
[14] K. Pienta. Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer. , 2001, Seminars in oncology.
[15] D. S. Lind,et al. Nuclear factor-κB is upregulated in colorectal cancer , 2001 .
[16] P. Elliott,et al. 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer , 2001, Journal of cellular biochemistry.
[17] S. Ikehara,et al. Proteasome inhibitor 1 enhances paclitaxel-induced apoptosis in human lung adenocarcinoma cell line. , 2001, Oncology reports.
[18] B. Aggarwal,et al. Antiproliferative Effects of IFN-α Correlate with the Downregulation of Nuclear Factor-κB in Human Burkitt Lymphoma Daudi Cells , 2001 .
[19] P. Elliott,et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. , 2001, Cancer research.
[20] Z Chen,et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[21] P. Elliott,et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. , 2001, Cancer research.
[22] D. Delia,et al. The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI , 2001, British journal of haematology.
[23] C. Watson,et al. p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells , 2001, Cell Death and Differentiation.
[24] C. Van Waes,et al. Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[25] P. Krammer,et al. Proteasome Inhibitor‐Induced Apoptosis of Glioma Cells Involves the Processing of Multiple Caspases and Cytochrome c Release , 2000, Journal of neurochemistry.
[26] W. Dalton,et al. The tumor microenvironment as a determinant of cancer cell survival: a possible mechanism for de novo drug resistance , 2000, Current opinion in oncology.
[27] G. Emons,et al. Luteinizing Hormone-Releasing Hormone Induces Nuclear Factorκ B-Activation and Inhibits Apoptosis in Ovarian Cancer Cells , 2000 .
[28] Steffen Hauptmann,et al. Proteasome inhibitors induce caspase‐dependent apoptosis and accumulationof p21WAF1/Cip1 in human immatureleukemic cells , 2000 .
[29] P. Elliott,et al. Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[30] S-G Hwang,et al. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition , 2000, Leukemia.
[31] W. McBride,et al. Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition. , 2000, International journal of radiation oncology, biology, physics.
[32] P. Elliott,et al. Proteasome inhibition measurements: clinical application. , 2000, Clinical chemistry.
[33] A. Tomida,et al. Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs. , 2000, Cancer research.
[34] C. Gélinas,et al. The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-xL , 2000, Molecular and Cellular Biology.
[35] C. Scheidereit,et al. Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells , 2000, Leukemia.
[36] E. Schattner,et al. Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells1 , 2000, The Journal of Immunology.
[37] W. Risau,et al. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[38] L. Bergmann,et al. Normal Structure of NFKB 2, C-REL and BCL-3 Gene Loci in Lymphoproliferative and Myeloproliferative Disorders , 2000, Leukemia & lymphoma.
[39] C. N. Coleman,et al. Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen , 1999, Oncogene.
[40] A. Waage,et al. Apoptosis, proliferation and NF‐κB activation induced by agonistic Fas antibodies in the human myeloma cell line OH‐2: amplification of Fas‐mediated apoptosis by tumor necrosis factor , 1999, European journal of haematology.
[41] V. Baldin,et al. Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage. , 1999, Biochemical and biophysical research communications.
[42] R. Herbst,et al. The proteasome inhibitor PS-341 in cancer therapy. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[43] Marty W. Mayo,et al. NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis , 1999, Molecular and Cellular Biology.
[44] J. Cusack,et al. NF- kappa B and chemoresistance: potentiation of cancer drugs via inhibition of NF- kappa B. , 1999, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[45] S Omura,et al. Increased sensitivity of CLL‐derived lymphocytes to apoptotic death activation by the proteasome‐specific inhibitor lactacystin , 1999, British journal of haematology.
[46] E. Sausville,et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. , 1999, Cancer research.
[47] B. Barlogie,et al. Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2. , 1999, Blood.
[48] M. Tomonaga,et al. Constitutive Activation of NF-κB in Primary Adult T-Cell Leukemia Cells , 1999 .
[49] J. Cusack,et al. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB , 1999, Nature Medicine.
[50] W. Dalton,et al. Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines , 1999 .
[51] T. McDonnell,et al. Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53 , 1998, Oncogene.
[52] K. Kliche,et al. Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes. , 1998, Blood.
[53] M. Grever,et al. Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. , 1998, Cancer research.
[54] C. Y. Wang,et al. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. , 1998, Science.
[55] S Omura,et al. The proteasome is involved in angiogenesis. , 1998, Biochemical and biophysical research communications.
[56] S. Ōmura,et al. The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis. , 1998, British Journal of Cancer.
[57] L. Dick,et al. Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. , 1998, Bioorganic & medicinal chemistry letters.
[58] A. E. Rogers,et al. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. , 1997, The Journal of clinical investigation.
[59] G. Sledge,et al. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth , 1997, Molecular and cellular biology.
[60] A. Goldberg,et al. Proteasomes play an essential role in thymocyte apoptosis. , 1996, The EMBO journal.
[61] J. Martinou,et al. Involvement of the proteasome in the programmed cell death of NGF‐deprived sympathetic neurons. , 1996, The EMBO journal.
[62] B. Dörken,et al. High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. , 1996, Blood.
[63] T. Libermann,et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. , 1996, Blood.
[64] M. Schmitt,et al. Inhibition of NF-KB-Rel A expression by antisense oligodeoxynucleotides suppresses synthesis of urokinase-type plasminogen activator (uPA) but not its inhibitor PAl-1 , 1995 .
[65] J. Roth,et al. Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma. , 1995, Oncogene.
[66] V. Castronovo,et al. The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines. , 1994, Biochemical pharmacology.
[67] J. Wolchok,et al. Activation of NF‐κB may be necessary but is not sufficient for induction of H‐2 antigens by TNF in J558L murine myeloma cells , 1994, Journal of leukocyte biology.
[68] K. Anderson,et al. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. , 1993, Blood.
[69] K. Tanaka,et al. Abnormally high expression of proteasomes in human leukemic cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[70] A. Kajdacsy-Balla,et al. The role of constitutive NF-κB activity in PC-3 human prostate cancer cell invasive behavior , 2004, Clinical & Experimental Metastasis.
[71] T. Slaga,et al. The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells. , 2002, Journal of cell science.
[72] A. Goldberg,et al. Proteasome inhibitors: from research tools to drug candidates. , 2001, Chemistry & biology.
[73] T. Hideshima,et al. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. , 2001, Oncogene.
[74] L. Neckers,et al. Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression. , 2001, Cellular and molecular biology.
[75] P. Elliott,et al. Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. , 2001, International journal of radiation oncology, biology, physics.
[76] Wim H. M. Saris,et al. Proceedings of the American Association for Cancer Research. , 2001 .
[77] J. Berenson,et al. The Role of Nuclear Factor-KB in the Biology and Treatment of Multiple Myeloma , 2001 .
[78] Douglas B. Evans,et al. The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells , 1999 .