Carvedilol blocks the repolarizing K+ currents and the L-type Ca2+ current in rabbit ventricular myocytes.
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I Kodama | J Toyama | K. Kamiya | I. Kodama | R. Niwa | J. Cheng | J. Toyama | K Kamiya | R Niwa | J Cheng | J. Cheng
[1] K. Kamiya,et al. Heterogeneous distribution of the two components of delayed rectifier K+ current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents. , 1999, Cardiovascular research.
[2] Bramahn . Singh,et al. Antiarrhythmic drugs: a reorientation in light of recent developments in the control of disorders of rhythm. , 1998, The American journal of cardiology.
[3] W. Frishman,et al. Results of therapy with carvedilol, a beta-blocker vasodilator with antioxidant properties, in hypertensive patients. , 1998, American journal of hypertension.
[4] G. Jennings,et al. Adrenergic nervous system in heart failure. , 1997, The American journal of cardiology.
[5] I Kodama,et al. Vesnarinone prolongs action potential duration without reverse frequency dependence in rabbit ventricular muscle by blocking the delayed rectifier K+ current. , 1997, Circulation.
[6] M. Janse,et al. Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials , 1997, The Lancet.
[7] M. Akhtar,et al. Evaluation and treatment strategies in patients at high risk of sudden death post myocardial infarction , 1997, Clinical cardiology.
[8] C. Dunn,et al. Carvedilol , 1997, Drugs.
[9] R. Senior,et al. Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomized trial. , 1997, Circulation.
[10] D. Wright,et al. Intractable recurrent ventricular tachycardia in dilated cardiomyopathy controlled by a vasodilating beta blocker. , 1997, Heart.
[11] B. Fermini,et al. IK of rabbit ventricle is composed of two currents: evidence for IKs. , 1996, The American journal of physiology.
[12] K. Adams,et al. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators. , 1996, Circulation.
[13] R. Berge,et al. Carvedilol improves function and reduces infarct size in the feline myocardium by protecting against lethal reperfusion injury. , 1996, European journal of pharmacology.
[14] K. Kamiya,et al. Differential effects of MS-551 and E-4031 on action potentials and the delayed rectifier K+ current in rabbit ventricular myocytes. , 1996, Cardiovascular research.
[15] J. Cohn,et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. , 1996, The New England journal of medicine.
[16] P. Kowey,et al. Randomized, double-blind comparison of intravenous amiodarone and bretylium in the treatment of patients with recurrent, hemodynamically destabilizing ventricular tachycardia or fibrillation. The Intravenous Amiodarone Multicenter Investigators Group. , 1995, Circulation.
[17] P. Kowey,et al. Dose-Ranging Study of Intravenous Amiodarone in Patients With Life-Threatening Ventricular Tachyarrhythmias , 1995 .
[18] F. Tristani,et al. Ejection Fraction, Peak Exercise Oxygen Consumption, Cardiothoracic Ratio, Ventricular Arrhythmias, and Plasma Norepinephrine as Determinants of Prognosis in Heart Failure , 1993, Circulation.
[19] D. McTavish,et al. Carvedilol , 2012, Drugs.
[20] K. Kamiya,et al. Effects of long‐term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle , 1992, British journal of pharmacology.
[21] E. Carmeliet. Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. , 1992, The Journal of pharmacology and experimental therapeutics.
[22] W. Giles,et al. Role of an inwardly rectifying potassium current in rabbit ventricular action potential. , 1992, The Journal of physiology.
[23] R. Senior,et al. Effects of carvedilol on ventricular arrhythmias. , 1992, Journal of cardiovascular pharmacology.
[24] W. Giles,et al. Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle. , 1991, The Journal of physiology.
[25] R. N. Brogden,et al. Atenolol , 1991, Drugs.
[26] U. Ravens,et al. Effects of the New Class III Antiarrhythmic Drug E‐4031 on Myocardial Contractility and Electrophysiological Parameters , 1991, Journal of cardiovascular pharmacology.
[27] A. Nichols,et al. Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol , 1991, Fundamental & clinical pharmacology.
[28] J. Arrowsmith,et al. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. , 1991, The Journal of pharmacology and experimental therapeutics.
[29] Trefor Owen Morgan,et al. Pharmacokinetics of carvedilol in older and younger patients. , 1990, Journal of human hypertension.
[30] H. Refsum,et al. Rate‐Dependent Class III Antiarrhythmic Action, Negative Chronotropy, and Positive Inotropy of a Novel Ik Blocking Drug, UK‐68,798: Potent in Guinea Pig but no Effect in Rat Myocardium , 1990, Journal of cardiovascular pharmacology.
[31] M. Sanguinetti,et al. Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents , 1990, The Journal of general physiology.
[32] J. Kjekshus. Arrhythmias and mortality in congestive heart failure. , 1990, The American journal of cardiology.
[33] D. Snyders,et al. Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. , 1990, Circulation.
[34] M. Kameyama,et al. An improved method for isolating cardiac myocytes useful for patch-clamp studies. , 1990, The Japanese journal of physiology.
[35] J. Mahmarian,et al. The inverse relationship between baseline left ventricular ejection fraction and outcome of antiarrhythmic therapy: a dangerous imbalance in the risk-benefit ratio. , 1989, American heart journal.
[36] Y. Hattori,et al. Vascular effects of carvedilol, a new beta-adrenoceptor antagonist with vasodilating properties, in isolated canine coronary artery. , 1989, Journal of cardiovascular pharmacology.
[37] M. Hiraoka,et al. Calcium‐sensitive and insensitive transient outward current in rabbit ventricular myocytes. , 1989, The Journal of physiology.
[38] V. Hombach,et al. Effects of carvedilol on left ventricular function and arrhythmias during repeated short-time myocardial ischemia in experimental pigs. , 1989, Zeitschrift fur Kardiologie.
[39] J. Hieble,et al. In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol. , 1989, Pharmacology.
[40] W. Giles,et al. Comparison of potassium currents in rabbit atrial and ventricular cells. , 1988, The Journal of physiology.
[41] U. Borchard,et al. Electrophysiological characterization of the class III activity of sotalol and its enantiomers. New interpretation of use-dependent effects. , 1988, Arzneimittel-Forschung.
[42] Bigger Jt. Why patients with congestive heart failure die: arrhythmias and sudden cardiac death. , 1987 .
[43] M. Packer,et al. Sudden unexpected death in patients with congestive heart failure: a second frontier. , 1985, Circulation.
[44] M. Gheorghiade,et al. Ventricular arrhythmias in severe heart failure: incidence, significance, and effectiveness of antiarrhythmic therapy. , 1985, American heart journal.