Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

[1]  B. Nehru,et al.  Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model , 2014, Neuropharmacology.

[2]  Seung-Jae Lee,et al.  Alpha-synuclein stimulation of astrocytes Potential role for neuroinflammation and neuroprotection , 2014 .

[3]  P. Wipf,et al.  Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells. , 2013, ACS chemical biology.

[4]  B. Nehru,et al.  Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson’s disease , 2013, Neuroscience.

[5]  A. Cooper,et al.  αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson's Disease? , 2012, Parkinson's disease.

[6]  S. Koppula,et al.  Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson's Disease , 2012, Mediators of inflammation.

[7]  S. Sugama,et al.  Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies , 2012, Parkinson's disease.

[8]  D. Thiele,et al.  Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases , 2011, Nature Reviews Drug Discovery.

[9]  B. Nehru,et al.  Curcumin Attenuates Aluminum-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain , 2011, Neurotoxicity Research.

[10]  R. Nussbaum,et al.  Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein*♦ , 2011, The Journal of Biological Chemistry.

[11]  Armin Giese,et al.  Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1 , 2010, The EMBO journal.

[12]  Steve D. M. Brown,et al.  α-Synuclein impairs macroautophagy: implications for Parkinson's disease , 2010 .

[13]  A. Ludolph,et al.  Effects of mitochondrial dysfunction on the immunological properties of microglia , 2010, Journal of Neuroinflammation.

[14]  Helga E de Vries,et al.  Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration? , 2010, Mitochondrion.

[15]  P. Calabresi,et al.  Mitochondria and the link between neuroinflammation and neurodegeneration. , 2010, Journal of Alzheimer's disease : JAD.

[16]  R. Cappai,et al.  α‐Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease , 2010, FEBS letters.

[17]  B. Nehru,et al.  Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease , 2009, Neurochemistry International.

[18]  Isidre Ferrer,et al.  Early involvement of the cerebral cortex in Parkinson's disease: Convergence of multiple metabolic defects , 2009, Progress in Neurobiology.

[19]  J. Trosko,et al.  Modulation of connexin 43 in rotenone-induced model of Parkinson's disease , 2009, Neuroscience.

[20]  Lucia Migliore,et al.  Environmental-induced oxidative stress in neurodegenerative disorders and aging. , 2009, Mutation research.

[21]  K. Ohtsuka,et al.  Reinvestigation of the effect of carbenoxolone on the induction of heat shock proteins , 2009, Cell Stress and Chaperones.

[22]  M. Cookson α-Synuclein and neuronal cell death , 2009, Molecular Neurodegeneration.

[23]  T. Kielian Glial connexins and gap junctions in CNS inflammation and disease , 2008, Journal of neurochemistry.

[24]  B. Nehru,et al.  Antioxidant Enzymatic System in Neuronal and Glial Cells Enriched Fractions of Rat Brain After Aluminum Exposure , 2007, Cellular and Molecular Neurobiology.

[25]  P. Lockhart,et al.  Oligomeric α-synuclein inhibits tubulin polymerization , 2007 .

[26]  Gary W Miller,et al.  Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease , 2007, Journal of neurochemistry.

[27]  P. Lockhart,et al.  Oligomeric alpha-synuclein inhibits tubulin polymerization. , 2007, Biochemical and biophysical research communications.

[28]  Tianhong Pan,et al.  Valproic acid‐mediated Hsp70 induction and anti‐apoptotic neuroprotection in SH‐SY5Y cells , 2005, FEBS letters.

[29]  Yumei Wang,et al.  Geldanamycin Induces Heat Shock Protein 70 and Protects against MPTP-induced Dopaminergic Neurotoxicity in Mice* , 2005, Journal of Biological Chemistry.

[30]  Belinda Wilson,et al.  Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  M. Richard,et al.  Protective effects of hsp70 in inflammation , 1994, Experientia.

[32]  P. Muchowski,et al.  Modulation of neurodegeneration by molecular chaperones , 2005, Nature Reviews Neuroscience.

[33]  N. Belluardo,et al.  Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs) , 2004, Neuropharmacology.

[34]  W. Dauer,et al.  Parkinson's Disease Mechanisms and Models , 2003, Neuron.

[35]  Todd B. Sherer,et al.  Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation , 2003, Experimental Neurology.

[36]  Mitsunobu Yoshii,et al.  α-Synuclein aggregation and neurodegenerative diseases , 2003 .

[37]  Yan Leng,et al.  Prostaglandin A1 inhibits rotenone‐induced apoptosis in SH‐SY5Y cells , 2002, Journal of neurochemistry.

[38]  N. C. Smith,et al.  Heat Shock Protein 70 Is a Potential Virulence Factor in Murine Toxoplasma Infection Via Immunomodulation of Host NF-κB and Nitric Oxide1 , 2002, The Journal of Immunology.

[39]  N. C. Smith,et al.  Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide. , 2002, Journal of immunology.

[40]  Todd B. Sherer,et al.  Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.

[41]  H. Ueda,et al.  Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction. , 2000, Life sciences.

[42]  M. Bansal,et al.  Department of Biophysics, Panjab University, Chandigarh-160014, India , 2000 .

[43]  J. Snaedal,et al.  Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease. , 1999, Pharmacology & toxicology.

[44]  S. Berman,et al.  Dopamine Oxidation Alters Mitochondrial Respiration and Induces Permeability Transition in Brain Mitochondria , 1999, Journal of neurochemistry.

[45]  H. Wong,et al.  HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats. , 1996, The American journal of physiology.

[46]  P. Mehlen,et al.  Human hsp27, Drosophila hsp27 and human alphaB‐crystallin expression‐mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha‐induced cell death. , 1996, The EMBO journal.

[47]  C. Marsden,et al.  Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia , 1994, Annals of neurology.

[48]  L. Franco,et al.  Anti-ulcer activity of carbenoxolone and ISF 3401 on PGE2 release in rat gastric mucosa. , 1993, Pharmacological research.

[49]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .