Abca7 deletion does not affect adult neurogenesis in the mouse

ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and linked with Alzheimer's disease. Since other ABC transporters regulate adult neurogenesis, we assessed neurogenesis in wild-type (WT) and Abca7 deficient mice. Abca7 deletion did not affect adult neurogenesis in the mouse.

[1]  Hongyun Li,et al.  Understanding the function of ABCA7 in Alzheimer's disease. , 2015, Biochemical Society transactions.

[2]  P. S. St George-Hyslop,et al.  ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing* , 2015, The Journal of Biological Chemistry.

[3]  J. Winkler,et al.  Adult neurogenesis in neurodegenerative diseases. , 2015, Cold Spring Harbor perspectives in biology.

[4]  H. Stefánsson,et al.  Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease , 2015, Nature Genetics.

[5]  V. Pankratz,et al.  Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease , 2015, Neurobiology of Aging.

[6]  D. Fardo,et al.  ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status , 2013, Neuroscience Letters.

[7]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[8]  Jason J. Corneveaux,et al.  Genetic susceptibility for Alzheimer disease neuritic plaque pathology. , 2013, JAMA neurology.

[9]  K. Lunetta,et al.  Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. , 2013, JAMA.

[10]  D. Elliott,et al.  Deletion of Abca7 Increases Cerebral Amyloid-β Accumulation in the J20 Mouse Model of Alzheimer's Disease , 2013, The Journal of Neuroscience.

[11]  Ellen C. Jensen*.  Quantitative Analysis of Histological Staining and Fluorescence Using ImageJ , 2013, Anatomical record.

[12]  Yuxin Ma,et al.  Intrahippocampal injection of Aβ1-42 inhibits neurogenesis and down-regulates IFN-γ and NF-κB expression in hippocampus of adult mouse brain , 2013, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[13]  F. Gage,et al.  Adult hippocampal neurogenesis and its role in Alzheimer's disease , 2011, Molecular Neurodegeneration.

[14]  Nick C Fox,et al.  Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease , 2011, Nature Genetics.

[15]  Michael P. Demars,et al.  Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice , 2010, Journal of neuroscience research.

[16]  S. Pimplikar,et al.  APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation , 2010, PloS one.

[17]  O. Lazarov,et al.  Neurogenesis and Alzheimer's disease: At the crossroads , 2010, Experimental Neurology.

[18]  E. Masliah,et al.  APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis , 2009, Brain Structure and Function.

[19]  A. Hill,et al.  ATP‐binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro , 2008, Journal of neurochemistry.

[20]  C. Weickert,et al.  Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease , 2008, Journal of neurochemistry.

[21]  Xin-Fu Zhou,et al.  Potential conversion of adult clavicle‐derived chondrocytes into neural lineage cells in vitro , 2008, Journal of cellular physiology.

[22]  F. Gage,et al.  Mechanisms and Functional Implications of Adult Neurogenesis , 2008, Cell.

[23]  Xin-Fu Zhou,et al.  Isolation and Characterization of Neural Crest Progenitors from Adult Dorsal Root Ganglia , 2007, Stem cells.

[24]  C. Rampon,et al.  Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis , 2007, The Journal of Neuroscience.

[25]  K. Heese,et al.  ABC transporters, neural stem cells and neurogenesis – a different perspective , 2006, Cell Research.

[26]  C. Lim,et al.  Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells , 2006, Neuroreport.

[27]  A. Nieoullon,et al.  ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain , 2006, Journal of neurochemistry.

[28]  K. Moore,et al.  Abca7 Null Mice Retain Normal Macrophage Phosphatidylcholine and Cholesterol Efflux Activity despite Alterations in Adipose Mass and Serum Cholesterol Levels* , 2005, Journal of Biological Chemistry.

[29]  M. Mattson,et al.  Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease , 2002, Journal of neurochemistry.

[30]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[31]  M. Luciani,et al.  The ABCA subclass of mammalian transporters. , 1999, Biochimica et biophysica acta.

[32]  S. Mcconnell,et al.  Doublecortin Is a Developmentally Regulated, Microtubule-Associated Protein Expressed in Migrating and Differentiating Neurons , 1999, Neuron.

[33]  C. Walsh,et al.  Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons , 1999, Neuron.

[34]  Alexander Meissner,et al.  Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. , 2015, JAMA neurology.