Characterization of the fatty-acid amide hydrolase inhibitor URB 597 : Effects on anandamide and oleoylethanolamide deactivation

Memory, University of California, Irvine, California 92697-4625 (D.F., S.G., D.P.), Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Urbino “Carlo Bo”,Piazza del Rinascimento 6, I-61029 Urbino, Italy (A.D., A.T., G.T.) and Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43100 Parma, Italy (M.M.) JPET Fast Forward. Published on December 3, 2004 as DOI:10.1124/jpet.104.078980

[1]  K. Mackie,et al.  Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension , 2004, Circulation.

[2]  Giovanni Piersanti,et al.  Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies. , 2004, Journal of medicinal chemistry.

[3]  B. Cravatt,et al.  Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. , 2004, Biochemistry.

[4]  D. Fegley,et al.  Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[5]  B. Cravatt,et al.  Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia , 2004, Pain.

[6]  N. Ueda,et al.  Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners* , 2004, Journal of Biological Chemistry.

[7]  D. Piomelli The molecular logic of endocannabinoid signalling , 2003, Nature Reviews Neuroscience.

[8]  S. Gaetani,et al.  Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α , 2003, Nature.

[9]  S. Gaetani,et al.  Modulation of Meal Pattern in the Rat by the Anorexic Lipid Mediator Oleoylethanolamide , 2003, Neuropsychopharmacology.

[10]  A. Duranti,et al.  Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. , 2003, Journal of medicinal chemistry.

[11]  S. Gaetani,et al.  Modulation of anxiety through blockade of anandamide hydrolysis , 2003, Nature Medicine.

[12]  B. Cravatt,et al.  The enzymatic inactivation of the fatty acid amide class of signaling lipids. , 2002, Chemistry and physics of lipids.

[13]  D. Piomelli,et al.  A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding , 2002, The Journal of Neuroscience.

[14]  M. Adler,et al.  CB1 receptors in the preoptic anterior hypothalamus regulate WIN 55212-2 [(4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-induced hypothermia. , 2002, The Journal of pharmacology and experimental therapeutics.

[15]  S. Gaetani,et al.  An anorexic lipid mediator regulated by feeding , 2001, Nature.

[16]  R. Capasso,et al.  Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation , 2001, British journal of pharmacology.

[17]  N. Ueda,et al.  Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance* , 2001, The Journal of Biological Chemistry.

[18]  B. Cravatt,et al.  Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[19]  J. Permert,et al.  Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats. , 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

[20]  D. Piomelli,et al.  Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. , 2000, Analytical biochemistry.

[21]  S. Yamamoto,et al.  An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors , 1999, FEBS letters.

[22]  D. Piomelli,et al.  Control of pain initiation by endogenous cannabinoids , 1998, Nature.

[23]  A. Rice,et al.  The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain , 1998, Pain.

[24]  D. Piomelli,et al.  Functional role of high-affinity anandamide transport, as revealed by selective inhibition. , 1997, Science.

[25]  D. Piomelli,et al.  A second endogenous cannabinoid that modulates long-term potentiation , 1997, Nature.

[26]  W. Campbell,et al.  Accumulation of N‐Arachidonoylethanolamine (Anandamide) into Cerebellar Granule Cells Occurs via Facilitated Diffusion , 1997, Journal of neurochemistry.

[27]  V. Natarajan,et al.  The N-acylation-phosphodiesterase pathway and cell signalling. , 1996, Chemistry and physics of lipids.

[28]  A. Yamashita,et al.  2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. , 1995, Biochemical and biophysical research communications.

[29]  Z. Vogel,et al.  Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. , 1995, Biochemical pharmacology.

[30]  J. Schwartz,et al.  Formation and inactivation of endogenous cannabinoid anandamide in central neurons , 1994, Nature.

[31]  D. Gibson,et al.  Isolation and structure of a brain constituent that binds to the cannabinoid receptor. , 1992, Science.

[32]  S. Cooper,et al.  THE EFFECT OF FENFLURAMINE ON THE MICROSTRUCTURE OF FEEDING AND DRINKING IN THE RAT , 1981, British journal of pharmacology.

[33]  F. Kuehl,et al.  THE IDENTIFICATION OF N-(2-HYDROXYETHYL)-PALMITAMIDE AS A NATURALLY OCCURRING ANTI-INFLAMMATORY AGENT , 1957 .