An updated Asia Pacific Consensus Recommendations on colorectal cancer screening

Objective Since the publication of the first Asia Pacific Consensus on Colorectal Cancer (CRC) in 2008, there are substantial advancements in the science and experience of implementing CRC screening. The Asia Pacific Working Group aimed to provide an updated set of consensus recommendations. Design Members from 14 Asian regions gathered to seek consensus using other national and international guidelines, and recent relevant literature published from 2008 to 2013. A modified Delphi process was adopted to develop the statements. Results Age range for CRC screening is defined as 50–75 years. Advancing age, male, family history of CRC, smoking and obesity are confirmed risk factors for CRC and advanced neoplasia. A risk-stratified scoring system is recommended for selecting high-risk patients for colonoscopy. Quantitative faecal immunochemical test (FIT) instead of guaiac-based faecal occult blood test (gFOBT) is preferred for average-risk subjects. Ancillary methods in colonoscopy, with the exception of chromoendoscopy, have not proven to be superior to high-definition white light endoscopy in identifying adenoma. Quality of colonoscopy should be upheld and quality assurance programme should be in place to audit every aspects of CRC screening. Serrated adenoma is recognised as a risk for interval cancer. There is no consensus on the recruitment of trained endoscopy nurses for CRC screening. Conclusions Based on recent data on CRC screening, an updated list of recommendations on CRC screening is prepared. These consensus statements will further enhance the implementation of CRC screening in the Asia Pacific region.

[1]  R. Houlston,et al.  Colorectal Cancer Mortality in First-Degree Relatives of Early-Onset Colorectal Cancer Cases , 2002, Diseases of the colon and rectum.

[2]  H. V. van Buuren,et al.  Varicella zoster-associated gastric ulcers, hepatitis and pancreatitis in an immunocompromised patient. , 2012, Endoscopy.

[3]  Douglas K Rex,et al.  Corrigendum: American College of Gastroenterology Guidelines for Colorectal Cancer Screening 2008 , 2009, The American Journal of Gastroenterology.

[4]  Y. Kopelman,et al.  Prospective Multicenter Performance Evaluation of the Second-Generation Colon Capsule Compared with Colonoscopy , 2010 .

[5]  D. Faigel,et al.  Polypectomy rate as a quality measure for colonoscopy. , 2011, Gastrointestinal endoscopy.

[6]  Hsiu‐Po Wang,et al.  Screening for Colorectal Cancer in Average-Risk Chinese Population Using a Mixed Strategy with Sigmoidoscopy and Colonoscopy , 2007, Diseases of the Colon & Rectum.

[7]  J. Rey,et al.  European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Professional requirements and training , 2012, Endoscopy.

[8]  A. Rostom,et al.  A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy. , 2006, Gastrointestinal endoscopy.

[9]  Fred S. Drennan,et al.  Screening Colonoscopy in Very Elderly Patients: Prevalence of Neoplasia and Estimated Impact on Life Expectancy , 2006 .

[10]  M. Bretthauer,et al.  Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial , 2009, BMJ : British Medical Journal.

[11]  Paul Collins,et al.  Colonoscopic withdrawal times and adenoma detection during screening colonoscopy , 2007 .

[12]  P. Boyle,et al.  Measures of familial aggregation depend on definition of family history: meta-analysis for colorectal cancer. , 2006, Journal of clinical epidemiology.

[13]  Paul Fockens,et al.  Burden of colonoscopy compared to non-cathartic CT-colonography in a colorectal cancer screening programme: randomised controlled trial , 2011, Gut.

[14]  S R Cole,et al.  A Randomised Trial of the Impact of New Faecal Haemoglobin Test Technologies on Population Participation in Screening for Colorectal Cancer , 2003, Journal of medical screening.

[15]  P. Grenier,et al.  Cost-effectiveness modeling of colorectal cancer: computed tomography colonography vs colonoscopy or fecal occult blood tests. , 2012, European journal of radiology.

[16]  L. Bisanti,et al.  Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial--SCORE. , 2011, Journal of the National Cancer Institute.

[17]  J. Inadomi,et al.  Comparisons of Screening Colonoscopy Performed by a Nurse Practitioner and Gastroenterologists: A Single-Center Randomized Controlled Trial , 2011, Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates.

[18]  R. Pearson Association of Colonoscopy and Death from Colorectal Cancer , 2009 .

[19]  Harminder Singh,et al.  Rate and Predictors of Early/Missed Colorectal Cancers After Colonoscopy in Manitoba: A Population-Based Study , 2010, The American Journal of Gastroenterology.

[20]  E. Kuipers,et al.  European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Management of lesions detected in colorectal cancer screening , 2012, Endoscopy.

[21]  Bernadette Mazurek Melnyk,et al.  Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement. , 2008, Annals of internal medicine.

[22]  Douglas K. Rex,et al.  Quality Indicators for Colonoscopy , 2006, Gastrointestinal endoscopy.

[23]  Alessandro Repici,et al.  Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study. , 2011, Gastrointestinal endoscopy.

[24]  Carlos Sofia,et al.  Acute pancreatitis associated with a nontraumatic, intramural duodenal hematoma , 2013, Endoscopy.

[25]  A. Adrain,et al.  A comparison of fecal occult-blood tests for colorectal-cancer screening. , 1996, The New England journal of medicine.

[26]  Charles J. Kahi,et al.  Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer. , 2006, Gastroenterology.

[27]  Justin C.Y. Wu,et al.  Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer. , 2013, Gastroenterology.

[28]  Reiko Nishihara,et al.  Long-term colorectal-cancer incidence and mortality after lower endoscopy. , 2013, The New England journal of medicine.

[29]  Qiwen Ben,et al.  Body mass index increases risk for colorectal adenomas based on meta-analysis. , 2012, Gastroenterology.

[30]  J. Barkin,et al.  CT Colonography versus Colonoscopy for the Detection of Advanced Neoplasia , 2008 .

[31]  C. Mathers,et al.  Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 , 2010, International journal of cancer.

[32]  Julian P T Higgins,et al.  Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis. , 2006, European journal of cancer.

[33]  William K K Wu,et al.  Cigarette smoking and the risk of colorectal cancer: a meta-analysis of prospective cohort studies. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[34]  Steve Halligan,et al.  Colorectal cancer: CT colonography and colonoscopy for detection--systematic review and meta-analysis. , 2011, Radiology.

[35]  Mark P Purdue,et al.  Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. , 2012, The New England journal of medicine.

[36]  S. Cole,et al.  Comparison of a brush‐sampling fecal immunochemical test for hemoglobin with a sensitive guaiac‐based fecal occult blood test in detection of colorectal neoplasia , 2006, Cancer.

[37]  D. Faigel,et al.  ASGE guideline: colorectal cancer screening and surveillance. , 2006, Gastrointestinal endoscopy.

[38]  S. Cole,et al.  Effect of dietary restriction on participation in faecal occult blood test screening for colorectal cancer , 2001, The Medical journal of Australia.

[39]  Takuya Inoue,et al.  Autofluorescence imaging with a transparent hood for detection of colorectal neoplasms: a prospective, randomized trial. , 2010, Gastrointestinal endoscopy.

[40]  Ananya Das,et al.  Comparison of the Yield and Miss Rate of Narrow Band Imaging and White Light Endoscopy in Patients Undergoing Screening or Surveillance Colonoscopy: A Meta-Analysis , 2012, The American Journal of Gastroenterology.

[41]  Jaap Stoker,et al.  Diagnostic value of CT-colonography as compared to colonoscopy in an asymptomatic screening population: a meta-analysis , 2011, European Radiology.

[42]  H. Brenner,et al.  Protection From Colorectal Cancer After Colonoscopy , 2011, Annals of Internal Medicine.

[43]  K. Quek,et al.  Colorectal cancer in Asians: a demographic and anatomic survey in Malaysian patients undergoing colonoscopy , 2005, Alimentary pharmacology & therapeutics.

[44]  W. Leung,et al.  Repeat-Screening Colonoscopy 5 Years After Normal Baseline-Screening Colonoscopy in Average-Risk Chinese: A Prospective Study , 2009, American Journal of Gastroenterology.

[45]  A. Kneebone,et al.  Clinical and pathologic outcomes of colorectal cancer in a multi-ethnic population. , 2008, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[46]  J. Williams,et al.  The national colonoscopy audit: a nationwide assessment of the quality and safety of colonoscopy in the UK , 2012, Gut.

[47]  D. Lieberman Progress and challenges in colorectal cancer screening and surveillance. , 2010, Gastroenterology.

[48]  A. Verbeek,et al.  Comparison of Guaiac and Immunochemical Fecal Occult Blood ests for Colorectal Cancer in a Screening Population , 2022 .

[49]  Young Sun Kim,et al.  Efficacy of computed virtual chromoendoscopy on colorectal cancer screening: a prospective, randomized, back-to-back trial of Fuji Intelligent Color Enhancement versus conventional colonoscopy to compare adenoma miss rates. , 2010, Gastrointestinal endoscopy.

[50]  W. Leung,et al.  Increasing incidence of colorectal cancer in Asia: implications for screening. , 2005, The Lancet. Oncology.

[51]  V. Sharma,et al.  Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. , 2003, Gastrointestinal endoscopy.

[52]  J. Bond,et al.  CIMP Status of Interval Colon Cancers: Another Piece to the Puzzle , 2010, The American Journal of Gastroenterology.

[53]  Jürgen Pohl,et al.  Pancolonic chromoendoscopy with indigo carmine versus standard colonoscopy for detection of neoplastic lesions: a randomised two-centre trial , 2010, Gut.

[54]  J. Barkin,et al.  Rates of New or Missed Colorectal Cancers After Colonoscopy and Their Risk Factors: A Population-Based Analysis , 2008 .

[55]  A. Barkun,et al.  Quality audit of colonoscopy reports amongst patients screened or surveilled for colorectal neoplasia. , 2012, World journal of gastroenterology.

[56]  J. Bond,et al.  Is BRAF Mutation Associated with Interval Colorectal Cancers? , 2010, Digestive Diseases and Sciences.

[57]  Guido Costamagna,et al.  Second-generation colon capsule endoscopy compared with colonoscopy. , 2011, Gastrointestinal endoscopy.

[58]  J. V Schönfeld [Colonoscopy versus fecal immunochemical testing in colorectal cancer screening]. , 2013, Zeitschrift fur Gastroenterologie.

[59]  E. Kuipers,et al.  Nurse endoscopists perform colonoscopies according to the international standard and with high patient satisfaction , 2012, Endoscopy.

[60]  M. Arain,et al.  Is KRAS Mutation Associated with Interval Colorectal Cancers? , 2010, Digestive Diseases and Sciences.

[61]  R. Steele,et al.  Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) , 2010, Gut.

[62]  C. Shun,et al.  Association between early stage colon neoplasms and false-negative results from the fecal immunochemical test. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[63]  Paul Fockens,et al.  Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. , 2012, The Lancet. Oncology.

[64]  K. Tsoi,et al.  Patients with polyps larger than 5 mm in computed tomography colonoscopy screening have high risk for advanced colonic neoplasia in Asia. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[65]  S. Saini,et al.  Effect of Flexible Sigmoidoscopy-Based Screening on Incidence and Mortality of Colorectal Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2012, PLoS medicine.

[66]  J. Bond,et al.  Colorectal cancers found after a complete colonoscopy. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[67]  Á. Lanas,et al.  Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies. , 2013, Gastrointestinal endoscopy.

[68]  Sarah K. McGill,et al.  Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics , 2013, Gut.

[69]  D. Ransohoff,et al.  Five-Year risk of colorectal neoplasia after negative screening colonoscopy , 2008, Acta Endoscopica.

[70]  E. Kuipers,et al.  Features of adenoma and colonoscopy associated with recurrent colorectal neoplasia based on a large community-based study. , 2013, Gastroenterology.

[71]  H. Park,et al.  Prospective, randomized, back-to-back trial evaluating the usefulness of i-SCAN in screening colonoscopy. , 2012, Gastrointestinal endoscopy.

[72]  D. Lieberman,et al.  Data quality of the German Screening Colonoscopy Registry , 2013, Endoscopy.

[73]  C. Lawton Long-term risk of colorectal cancer after negative colonoscopy , 2012 .

[74]  J. Habbema,et al.  Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy , 2009, Gut.

[75]  M. Zwahlen,et al.  Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies , 2008, The Lancet.

[76]  S. Ng,et al.  The Effi cacy of Cap-Assisted Colonoscopy in Polyp Detection and Cecal Intubation : A Meta-Analysis of Randomized Controlled Trials , 2012 .

[77]  Charles J. Kahi,et al.  High-Definition Chromocolonoscopy vs. High-Definition White Light Colonoscopy for Average-Risk Colorectal Cancer Screening , 2010, The American Journal of Gastroenterology.

[78]  F. Chan,et al.  Perceived Obstacles of Colorectal Cancer Screening and Their Associated Factors among 10,078 Chinese Participants , 2013, PloS one.

[79]  B. Levin,et al.  Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. , 2008, Gastroenterology.

[80]  M. Lapalus,et al.  Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. , 2009, The New England journal of medicine.

[81]  R. Barclay,et al.  Effect of a time-dependent colonoscopic withdrawal protocol on adenoma detection during screening colonoscopy. , 2008, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[82]  Young Sun Kim,et al.  Five-year risk for advanced colorectal neoplasia after initial colonoscopy according to the baseline risk stratification: a prospective study in 2452 asymptomatic Koreans , 2011, Gut.

[83]  Han-Mo Chiu,et al.  Performance of the immunochemical fecal occult blood test in predicting lesions in the lower gastrointestinal tract , 2011, Canadian Medical Association Journal.

[84]  S. Moss,et al.  Longer mean colonoscopy withdrawal time is associated with increased adenoma detection: evidence from the Bowel Cancer Screening Programme in England , 2012, Endoscopy.

[85]  N. Segnan,et al.  European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Principles of evidence assessment and methods for reaching recommendations , 2012, Endoscopy.

[86]  T. Tuohy,et al.  Hereditary and familial colon cancer. , 2010, Gastroenterology.

[87]  W. Maule,et al.  Screening for colorectal cancer by nurse endoscopists. , 1994, The New England journal of medicine.

[88]  P. Maisonneuve,et al.  Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps. , 2008, Gastroenterology.

[89]  Dawn Provenzale,et al.  Five-year colon surveillance after screening colonoscopy. , 2007, Gastroenterology.

[90]  P. Pickhardt Polyp detection at CT colonography: inadequate primary 3D endoluminal reference standard precludes meaningful comparison. , 2007, Radiology.

[91]  J Pohl,et al.  Computed virtual chromoendoscopy versus standard colonoscopy with targeted indigocarmine chromoscopy: a randomised multicentre trial , 2008, Gut.

[92]  R. Pearson Analysis of Administrative Data Finds Endoscopist Quality Measures Associated With Postcolonoscopy Colorectal Cancer , 2011 .

[93]  Colon capsule endoscopy. , 2015, Gastrointestinal endoscopy clinics of North America.

[94]  M. Kochman Microsatellite Instability in Interval Colon Cancers , 2007 .

[95]  Perry J Pickhardt,et al.  Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi‐Society Task Force on Colorectal Cancer, and the American College of Radiology * † , 2008, CA: a cancer journal for clinicians.

[96]  T. Stukel,et al.  Association Between Colonoscopy Rates and Colorectal Cancer Mortality , 2010, The American Journal of Gastroenterology.

[97]  R. Houlston,et al.  A systematic review and meta-analysis of familial colorectal cancer risk , 2001, American Journal of Gastroenterology.

[98]  A. Nagorni,et al.  Narrow band imaging versus conventional white light colonoscopy for the detection of colorectal polyps. , 2012, The Cochrane database of systematic reviews.

[99]  J. Ho,et al.  A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population , 2003, Alimentary pharmacology & therapeutics.

[100]  C. Hawkey,et al.  High definition colonoscopy vs. standard video endoscopy for the detection of colonic polyps: a meta-analysis , 2011, Endoscopy.

[101]  F. Chan,et al.  A comparison of the acceptance of immunochemical faecal occult blood test and colonoscopy in colorectal cancer screening: a prospective study among Chinese , 2010, Alimentary pharmacology & therapeutics.

[102]  B. Wiedenmann,et al.  Latest generation, wide-angle, high-definition colonoscopes increase adenoma detection rate. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[103]  S. Cole,et al.  Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasia. , 2010, Gastroenterology.

[104]  D. Lieberman How good is your dentist? How good is your endoscopist? The quality imperative. , 2012, Gastroenterology.

[105]  Five-Year Incidence of Advanced Neoplasia After Initial Colonoscopy in Japan: A Multicenter Retrospective Cohort Study , 2009 .

[106]  Cancer,et al.  Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial , 2010, The Lancet.

[107]  Henrik Stovring,et al.  Proton Pump Inhibitor or Testing for Helicobacter pylori as the First Step for Patients Presenting with Dyspepsia? A Cluster-Randomized Trial , 2006, The American Journal of Gastroenterology.

[108]  J. GarcíaSánchez [Colonoscopic polypectomy and long-term prevention of colorectal cancer deaths]. , 2012 .

[109]  Steven R. Brown,et al.  Chromoscopy versus conventional endoscopy for the detection of polyps in the colon and rectum. , 2016, The Cochrane database of systematic reviews.

[110]  J. Sung,et al.  The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects , 2011, Gut.

[111]  S. Ryu,et al.  Comparison of Guaiac-Based and Quantitative Immunochemical Fecal Occult Blood Testing in a Population at Average Risk Undergoing Colorectal Cancer Screening , 2010, The American Journal of Gastroenterology.

[112]  E. Kuipers,et al.  A back-to-back comparison of white light video endoscopy with autofluorescence endoscopy for adenoma detection in high-risk subjects , 2010, Gut.

[113]  E. Kuipers,et al.  Time requirements and health effects of participation in colorectal cancer screening with colonoscopy or computed tomography colonography in a randomized controlled trial , 2013, Endoscopy.

[114]  Douglas K Rex,et al.  Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. , 2012, Gastroenterology.

[115]  H. Tajiri,et al.  Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline , 2012, Endoscopy.

[116]  G A Colditz,et al.  A prospective study of family history and the risk of colorectal cancer. , 1994, The New England journal of medicine.

[117]  Harminder Singh,et al.  Colonoscopic screening for colorectal cancer. , 2006, JAMA.

[118]  D. Ahnen,et al.  Are colorectal cancer screening recommendations for first-degree relatives of patients with adenomas too aggressive? , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[119]  E. Kliewer,et al.  The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer. , 2010, Gastroenterology.

[120]  T. Stukel,et al.  Association between colonoscopy and colorectal cancer mortality in a US cohort according to site of cancer and colonoscopist specialty. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[121]  D. Qiu,et al.  Comparison of time trends in liver cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. , 2007, Japanese journal of clinical oncology.

[122]  A. Kalloo,et al.  Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup. , 2012, World journal of gastroenterology.

[123]  M. Phipps,et al.  Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. , 2016, JAMA.

[124]  P. Glasziou,et al.  Cochrane Systematic Review of Colorectal Cancer Screening Using the Fecal Occult Blood Test (Hemoccult): An Update , 2008, The American Journal of Gastroenterology.

[125]  J. Cuzick,et al.  European guidelines for quality assurance in colorectal cancer screening and diagnosis: Overview and introduction to the full Supplement publication , 2012, Endoscopy.

[126]  Sachiko Tanaka,et al.  Comparison of time trends in colorectal cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. , 2007, Japanese journal of clinical oncology.

[127]  F. Chan,et al.  Asia Pacific consensus recommendations for colorectal cancer screening , 2008, Gut.