The effects of endogenous hypergastrinemia and hypogastrinemia on the exocrine and endocrine rat pancreas.

The effects of endogenous hypergastrinemia and hypogastrinemia on the exocrine and endocrine pancreas were studied in the rat. Hypergastrinemia was induced by antral exclusion, and hypogastrinemia by antral resection. The studies were made 14 weeks after surgery. The total weight of the pancreas was increased both in hypergastrinemic and hypogastrinemic animals, due to hypertrophy of the exocrine cells. In contrast, the volume and total weight of the pancreatic islets were decreased. There was no numerical difference in the A-, D-, PP-cells between the hyper- and hypogastrinemic animals, respectively, and the controls. The number of insulin-producing (B-) cells was certainly reduced after the induction of hypogastrinemia. There was, however, signs of increased B-cell activity, which might contribute to an underestimation of the number of B-cells with the technique used. These findings do not support the hypothesis that antral gastrin has trophic influence on either exocrine or endocrine pancreas.

[1]  F. Sundler,et al.  Variated serum gastrin concentration: trophic effects on the gastrointestinal tract of the rat. , 1979, Acta physiologica Scandinavica. Supplementum.

[2]  T. Solomon,et al.  Effect of chronic pentagastrin, cholecystokinin, and secretin on pancreas of rats. , 1978, The American journal of physiology.

[3]  J. Rehfeld,et al.  The effect of gastrin on basal and aminoacid‐stimulated insulin and glucagon secretion in man , 1978, European journal of clinical investigation.

[4]  S. Gustavsson.  Propulsion and mixing of small bowel contents : an experimental study in the rat with special reference to gastrin and some hypergastrinemic states , 1978 .

[5]  L. Wide,et al.  Serum gastrin determination with a radioimmunosorbent technique. , 1977, Clinica chimica acta; international journal of clinical chemistry.

[6]  L. Way,et al.  Trophic effects of gastrin on the exocrine pancreas in rats. , 1977, The Journal of surgical research.

[7]  L. Johnson,et al.  Evidence that Secretin Does not Have Direct Antitrophic Effects on the Rat Stomach , 1976, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[8]  J. Rehfeld,et al.  Disturbed islet-cell function related to endogenous gastrin release. Studies on insulin secretion and glucose tolerance in pernicious anemia. , 1976, The Journal of clinical investigation.

[9]  L. Johnson.  The trophic action of gastrointestinal hormones. , 1976, Gastroenterology.

[10]  J. Walsh,et al.  Gastrin (second of two parts). , 1975, The New England journal of medicine.

[11]  J. Walsh,et al.  Gastrin (first of two parts). , 1975, The New England journal of medicine.

[12]  Coons Ah.  Fluorescent antibody methods , 1968 .

[13]  G. Hultquist.  Nuclear size in the cells of Langerhans' islets during starvation in the rat. , 1962, Acta anatomica.

[14]  B. Hellman,et al.  Some aspects of silver impregnation of the islets of Langerhans in the rat. , 1960, Acta endocrinologica.

[15]  B. Hellman,et al.  Methodological aspects on the differential cell count of the islet tissue in the rat. , 2009 .