Meeting report - Cell size and growth: from single cells to the tree of life.

In April 2022, The Company of Biologists hosted their first post-pandemic in-person Workshop at Buxted Park Country House in the Sussex countryside. The Workshop, entitled 'Cell size and growth: from single cells to the tree of life', gathered a small group of early-career and senior researchers with expertise in cell size spanning a broad range of organisms, including bacteria, yeast, animal cells, embryos and plants, and working in fields from cell biology to ecology and evolutionary biology. The programme made ample room for fruitful discussions and provided a much-needed opportunity to discuss the most recent findings relating to the regulation of cell size and growth, identify the emerging challenges for the field, and build a community after the pandemic.

[1]  William B. Mair,et al.  Ultra-sensitive coupling between organ growth and size by YAP-1 ensures uniform body plan proportions in C. elegans , 2022, bioRxiv.

[2]  R. Heald,et al.  Dodecaploid Xenopus longipes provides insight into the emergence of size scaling relationships during development , 2022, Current Biology.

[3]  D. S. Glazier.  How Metabolic Rate Relates to Cell Size , 2022, Biology.

[4]  R. Heald,et al.  Scaling of biosynthesis and metabolism with cell size , 2022, Molecular biology of the cell.

[5]  C. Bakal,et al.  Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer , 2022, bioRxiv.

[6]  Klement Stojanovski,et al.  Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans , 2022, Nature Communications.

[7]  C. Jacobs-Wagner,et al.  Connecting single-cell ATP dynamics to overflow metabolism, cell growth, and the cell cycle in Escherichia coli , 2022, Current Biology.

[8]  P. Nurse,et al.  A quantitative and spatial analysis of cell cycle regulators during the fission yeast cycle , 2022, bioRxiv.

[9]  Z. Storchová,et al.  Peer Review File Manuscript Title: Genetic instability from a single S-phase after whole genome duplication Reviewer Comments & Author Rebuttals , 2022 .

[10]  B. Edgar,et al.  Translational control of E2f1 regulates the Drosophila cell cycle , 2022, Proceedings of the National Academy of Sciences.

[11]  Thomas G. Fai,et al.  Control of nuclear size by osmotic forces in Schizosaccharomyces pombe , 2021, bioRxiv.

[12]  P. Nurse,et al.  Core control principles of the eukaryotic cell cycle , 2021, Nature.

[13]  A. Kundaje,et al.  Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size. , 2021, Molecular cell.

[14]  D. Serbanescu,et al.  Cellular resource allocation strategies for cell size and shape control in bacteria , 2021, The FEBS journal.

[15]  V. Savage,et al.  Cancer as a Model System for Testing Metabolic Scaling Theory , 2021, Frontiers in Ecology and Evolution.

[16]  A. Kundaje,et al.  RNA polymerase II dynamics and mRNA stability feedback scale mRNA in proportion to cell size , 2021, bioRxiv.

[17]  G. Marinov,et al.  Increasing cell size remodels the proteome and promotes senescence , 2021, bioRxiv.

[18]  C. Gutiérrez,et al.  Cell size controlled in plants using DNA content as an internal scale , 2021, Science.

[19]  M. Mann,et al.  Scaling of cellular proteome with ploidy , 2021, bioRxiv.

[20]  Yuki Shindo,et al.  Excess histone H3 is a competitive Chk1 inhibitor that controls cell-cycle remodeling in the early Drosophila embryo , 2021, Current Biology.

[21]  Michael J. Lawson,et al.  Imaging-based screens of pool-synthesized cell libraries , 2021, Nature Methods.

[22]  S. Morrison,et al.  Cell size is a determinant of stem cell potential during aging , 2020, bioRxiv.

[23]  Abhyudai Singh,et al.  Transcription coordinates histone amounts and genome content , 2020, Nature Communications.

[24]  S. Manalis,et al.  Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle- and cell size-dependent growth , 2020, Proceedings of the National Academy of Sciences.

[25]  Adam M. Session,et al.  Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri , 2019, Current Biology.

[26]  R. Heald,et al.  Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling , 2019, Cell.

[27]  S. Manalis,et al.  Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence , 2019, Cell.

[28]  G. Facchetti,et al.  Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast , 2019, Current Biology.

[29]  C. Policarpi,et al.  HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State , 2018, Cell reports.

[30]  J. Skotheim,et al.  Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division , 2018, bioRxiv.

[31]  D. Gower,et al.  Macroevolutionary shift in the size of amphibian genomes and the role of life history and climate , 2018, Nature Ecology & Evolution.

[32]  James C. W. Locke,et al.  Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal , 2017, eLife.

[33]  P. Nurse,et al.  CDK Substrate Phosphorylation and Ordering the Cell Cycle , 2016, Cell.

[34]  J. Hayles,et al.  A genome–wide screen to identify genes controlling the rate of entry into mitosis in fission yeast , 2016, Cell cycle.

[35]  J. Skotheim,et al.  Dilution of the cell cycle inhibitor Whi5 controls budding yeast cell size , 2015, Nature.

[36]  P. Nurse,et al.  Nuclear size control in fission yeast , 2007, The Journal of cell biology.

[37]  James H Brown,et al.  Scaling of number, size, and metabolic rate of cells with body size in mammals , 2007, Proceedings of the National Academy of Sciences.