Associations between vascular endothelial growth factor gene polymorphisms and pre-eclampsia susceptibility: a meta-analysis

Objective: The aim of this study was to assess whether vascular endothelial growth factor (VEGF) polymorphisms are associated with susceptibility to pre-eclampsia. Methods: A meta-analysis was conducted on the associations between the −634 C/G, +936 C/T, −1154 A/G, and −2578 A/C polymorphisms of VEGF and pre-eclampsia. Results: Ten studies involving 2068 subjects (pre-eclampsia, 950; controls, 1118) were included in the meta-analysis. The meta-analysis revealed an association between pre-eclampsia and the VEGF −634 C allele in overall group (OR = 1.351, 95% CI = 1.105–1.651, p = 0.003) and in European group (OR = 1.427, 95% CI = 1.139–1.787, p = 0.002). The meta-analysis revealed an association between pre-eclampsia and the VEGF −936 T allele in Asians, but not in Europeans (OR = 1.555, 95% CI = 1.232–1.961, p = 1.9 × 10−5; OR = 1.587, 95% CI = 0.933–2.699, p = 0.088). However, the meta-analysis revealed no association between pre-eclampsia and the VEGF −1154 A/G and 2578 A/C polymorphisms Conclusions: This meta-analysis suggested that the VEGF −634 C/G polymorphism is associated with susceptibility to pre-eclampsia in Europeans and that the VEGF −634 C/G polymorphism is associated with pre-eclampsia in Asians.

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