Circadian synchrony in networks of protein rhythm driven neurons

The interaction between gene activation and cellular activity has recently emerged as a critical aspect of brain behavior, but the dynamics of networks incorporating these interactions are poorly understood. An interesting phenomena arises when the genetic activation oscillates endogenously and a network of such cells synchronize to a coherent rhythm, such as is the case with the suprachiasmatic nucleus. To explain this synchronization, we propose a model in which a mRNA/protein expression cycle drives neurons electrical activity, and synaptic activation shifts the phase of the protein rhythm. Using lattice networks, we demonstrate that these interactions are sufficient to generate coherent oscillation. © 2006 Wiley Periodicals, Inc. Complexity 12: 67–72, 2006

[1]  Sato Honma,et al.  Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period , 2004, Neuroscience Letters.

[2]  Steven M Reppert,et al.  GABA Synchronizes Clock Cells within the Suprachiasmatic Circadian Clock , 2000, Neuron.

[3]  Karl Deisseroth,et al.  Ca2+-dependent regulation in neuronal gene expression , 1997, Current Opinion in Neurobiology.

[4]  A. B. Reddy,et al.  Differential Resynchronisation of Circadian Clock Gene Expression within the Suprachiasmatic Nuclei of Mice Subjected to Experimental Jet Lag , 2002, The Journal of Neuroscience.

[5]  Steven H. Strogatz,et al.  Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei , 1997, Cell.

[6]  Yoshiyuki Sakaki,et al.  Temporal Precision in the Mammalian Circadian System: A Reliable Clock from Less Reliable Neurons , 2004, Journal of biological rhythms.

[7]  M. Kochen,et al.  Contacts and influence , 1978 .

[8]  Richard Bertram,et al.  Intra- and inter-islet synchronization of metabolically driven insulin secretion. , 2005, Biophysical journal.

[9]  Markus Meister,et al.  Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms , 1995, Neuron.

[10]  Y Sakaki,et al.  Resetting central and peripheral circadian oscillators in transgenic rats. , 2000, Science.

[11]  W. Gerstner.  Integrate-and-Fire Neurons and Networks , 2002 .

[12]  S. Bernard,et al.  Spontaneous synchronization of coupled circadian oscillators. , 2005, Biophysical journal.

[13]  C. Pennartz,et al.  A Mathematical Model for the Intracellular Circadian Rhythm Generator , 1999, The Journal of Neuroscience.

[14]  William J Schwartz,et al.  The suprachiasmatic nucleus is a functionally heterogeneous timekeeping organ. , 2005, Methods in enzymology.

[15]  Yasufumi Shigeyoshi,et al.  An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center , 2003, The Journal of Neuroscience.

[16]  Y. Kuramoto,et al.  Statistical macrodynamics of large dynamical systems. Case of a phase transition in oscillator communities , 1987 .

[17]  Hilmar Bading,et al.  Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity , 2001, Nature Neuroscience.

[18]  S. Yamaguchi,et al.  Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus , 2003, Science.

[19]  William J Schwartz,et al.  Forced Desynchronization of Dual Circadian Oscillators within the Rat Suprachiasmatic Nucleus , 2004, Current Biology.

[20]  Chris Arney.  Sync: The Emerging Science of Spontaneous Order , 2007 .

[21]  M. Vansteensel,et al.  A GABAergic Mechanism Is Necessary for Coupling Dissociable Ventral and Dorsal Regional Oscillators within the Circadian Clock , 2005, Current Biology.

[22]  Duncan J. Watts,et al.  Collective dynamics of ‘small-world’ networks , 1998, Nature.

[23]  Lily Yan,et al.  Two Antiphase Oscillations Occur in Each Suprachiasmatic Nucleus of Behaviorally Split Hamsters , 2005, The Journal of Neuroscience.

[24]  Nicholas C. Foley,et al.  Gates and Oscillators: A Network Model of the Brain Clock , 2003, Journal of biological rhythms.

[25]  L. Glass.  Cardiac Oscillations and Arrhythmia Analysis , 2006 .

[26]  Rae Silver,et al.  Organization of suprachiasmatic nucleus projections in Syrian hamsters (Mesocricetus auratus): An anterograde and retrograde analysis , 2004, The Journal of comparative neurology.

[27]  Rae Silver,et al.  Phase Resetting Light Pulses Induce Per1 and Persistent Spike Activity in a Subpopulation of Biological Clock Neurons , 2003, The Journal of Neuroscience.

[28]  Pérez,et al.  Synchronization, diversity, and topology of networks of integrate and fire oscillators , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[29]  Berj L Bardakjian,et al.  A synaptic input portal for a mapped clock oscillator model of neuronal electrical rhythmic activity , 2004, Journal of neural engineering.

[30]  Sato Honma,et al.  Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons , 2000, Neuroscience Letters.

[31]  Lance J. Kriegsfeld,et al.  Targeted Microlesions Reveal Novel Organization of the Hamster Suprachiasmatic Nucleus , 2004, The Journal of Neuroscience.

[32]  Peter Achermann,et al.  Simulation of circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators. , 2003, Journal of theoretical biology.