Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART

The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0–9; P < 0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.

[1]  AJ Busti,et al.  A prospective evaluation of the effect of atazanavir on the QTc interval and QTc dispersion in HIV‐positive patients , 2006, HIV medicine.

[2]  J. Leider,et al.  Importance of hepatitis C coinfection in the development of QT prolongation in HIV-infected patients. , 2006, Journal of electrocardiology.

[3]  M. Sani,et al.  QTc interval prolongation in patients with HIV and AIDS. , 2005, Journal of the National Medical Association.

[4]  Michael J Ackerman,et al.  Blockade of HERG channels by HIV protease inhibitors , 2005, The Lancet.

[5]  N. El-Sherif,et al.  Efavirenz-Associated QT Prolongation and Torsade de Pointes Arrhythmia , 2002, The Annals of pharmacotherapy.

[6]  M. Schluchter,et al.  Left ventricular structure and function in children infected with human immunodeficiency virus: the prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group. , 1998, Circulation.

[7]  K. Baughman,et al.  Immunopathogenesis of HIV-1-associated cardiomyopathy. , 1993, Clinical immunology and immunopathology.

[8]  S. Kaul,et al.  Cardiac manifestations of acquired immune deficiency syndrome: a 1991 update. , 1991, American heart journal.

[9]  W. Grody,et al.  Infection of the heart by the human immunodeficiency virus. , 1990, The American journal of cardiology.

[10]  J. Stewart,et al.  Symptomatic cardiac dysfunction in children with human immunodeficiency virus infection. , 1989, American heart journal.