Conjugated Linoleic Acid: The Present State of Knowledge

[1]  A. Valenzuela,et al.  Marine oils: the health benefits of n-3 fatty acids. , 2009, Nutrition reviews.

[2]  D. Bauman,et al.  Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. , 1999, The Journal of nutrition.

[3]  J. Sell,et al.  Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. , 1999, Poultry science.

[4]  L. Lea,et al.  Investigation of the potential of conjugated linoleic acid (Cla) to cause peroxisome proliferation in rats. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  D. Bauman,et al.  Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. , 1999, The Journal of nutrition.

[6]  H. Steinhart,et al.  The potential anticarcinogenic conjugated linoleic acid, cis-9,trans-11 C18:2, in milk of different species: Cow, goat, ewe, sow, mare, woman , 1999 .

[7]  J. M. V. van Amelsvoort,et al.  Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster , 1999, British Journal of Nutrition.

[8]  M. Pariza,et al.  Conjugated linoleic acid content of milk from cows fed different diets. , 1999, Journal of dairy science.

[9]  L. Luedecke,et al.  Conjugated Linoleic Acid Content of Cheddar-type Cheeses as Affected by Processing , 1999 .

[10]  Y. J. Kim,et al.  Selective Increase in Conjugated Linoleic Acid in Milk Fat by Crystallization , 1999 .

[11]  N. Choi,et al.  Effect of dietary lipid on the content of conjugated linoleic acid (CLA) in beef muscle , 1999 .

[12]  J. V. Vanden Heuvel,et al.  Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. , 1999, Journal of lipid research.

[13]  J. Sell,et al.  Transfer of dietary conjugated linoleic acid to egg yolks of chickens. , 1999, Poultry science.

[14]  D. Bauman,et al.  Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. , 1999, The Journal of nutrition.

[15]  C. Ip,et al.  Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. , 1999, Experimental cell research.

[16]  E. Okine,et al.  Effect of feeding canola oil on constituents, conjugated linoleic acid (CLA) and long chain fatty acids in goats milk , 1999 .

[17]  M. Mossoba,et al.  Impact of novel methodologies on the analysis of conjugated linoleic acid (CLA). Implications of CLA feeding studies , 1999 .

[18]  B. Watkins,et al.  Dietary Conjugated Linoleic Acids Alter Serum IGF‐I and IGF Binding Protein Concentrations and Reduce Bone Formation in Rats Fed (n‐6) or (n‐3) Fatty Acids , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  A. Wolk,et al.  Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. , 1999, The American journal of clinical nutrition.

[20]  M. Sugano,et al.  Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. , 1999, Bioscience, biotechnology, and biochemistry.

[21]  H. Thompson,et al.  Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. , 1999, Carcinogenesis.

[22]  G. Stangl,et al.  Energy balance of conjugated linoleic acid‐treated pigs , 1999 .

[23]  J. Sell,et al.  Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. , 1999, Poultry science.

[24]  J. Molkentin,et al.  Bioactive lipids naturally occurring in bovine milk. , 1999, Die Nahrung.

[25]  G. Mcneill,et al.  Antiplatelet effects of conjugated linoleic acid isomers. , 1999, Biochimica et biophysica acta.

[26]  C. Stanton,et al.  Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. , 1999, Anticancer research.

[27]  D. Ma,et al.  Conjugated linoleic acid in canadian dairy and beef products. , 1999, Journal of agricultural and food chemistry.

[28]  H. Steinhart,et al.  Improved separation of conjugated fatty acid methyl esters by silver ion-high-performance liquid chromatography , 1999, Lipids.

[29]  K. Thompson,et al.  Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model , 1999, British Journal of Nutrition.

[30]  V. Manning,et al.  Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. , 1999, The Journal of nutrition.

[31]  Yeonhwa Park,et al.  Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice , 1999, Lipids.

[32]  M. Cook,et al.  Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid , 1999, Lipids.

[33]  A. Davis,et al.  Analysis of conjugated linoleic acid isomers by 13C NMR spectroscopy , 1999 .

[34]  M. Belury,et al.  Conjugated linoleic acid activates peroxisome proliferator-activated receptor α and β subtypes but does not induce hepatic peroxisome proliferation in Sprague–Dawley rats , 1999 .

[35]  C. Stanton,et al.  Elevation of conjugated cis-9, trans-11-octadecadienoic acid in bovine milk because of dietary supplementation. , 1998, Journal of dairy science.

[36]  J. Loor,et al.  Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis. , 1998, The Journal of nutrition.

[37]  J. Fritsche,et al.  Occurrence of conjugated linoleic acid isomers in beef , 1998 .

[38]  M. Mossoba,et al.  Identification of conjugated linoleic acid isomers in cheese by gas chromatography, silver ion high performance liquid chromatography and mass spectral reconstructed ion profiles. Comparison of chromatographic elution sequences , 1998, Lipids.

[39]  R. G. Ackman.  Laboratory preparation of conjugated linoleic acids , 1998 .

[40]  M. Mossoba,et al.  Rumenic acid: A proposed common name for the major conjugated linoleic acid isomer found in natural products , 1998, Lipids.

[41]  H. Steinhart,et al.  A new conjugated linoleic acid isomer, 7 trans, 9 cis-octadecadienoic acid, in cow milk, cheese, beef and human milk and adipose tissue , 1998, Lipids.

[42]  K. N. Lee,et al.  Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. , 1998, Biochemical and biophysical research communications.

[43]  H. Steinhart,et al.  Analysis, occurrence, and physiological properties of trans fatty acids (TFA) with particular emphasis on conjugated linoleic acid isomers (CLA) – a review , 1998 .

[44]  A. Schaefer,et al.  Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver ion-high-performance liquid chromatography , 1998, Lipids.

[45]  T. Yanagita,et al.  10trans, 12cis-Linoleic acid reduces apolipoprotein B secretion in HepG2 cells , 1998 .

[46]  B. Kennedy,et al.  Regulation of the cellular expression of secretory and cytosolic phospholipases A2, and cyclooxygenase-2 by peptide growth factors. , 1998, Biochimica et biophysica acta.

[47]  M. Belury,et al.  Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes. , 1998, Cancer letters.

[48]  B. Watkins,et al.  Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio , 1998 .

[49]  M. Sugano,et al.  Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats , 1998, Lipids.

[50]  A. Cesano,et al.  Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. , 1998, Anticancer research.

[51]  D. A. Dwyer,et al.  Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. , 1998, The Journal of nutrition.

[52]  B. Watkins,et al.  Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids , 1998, Lipids.

[53]  J. V. Vanden Heuvel,et al.  Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. , 1998, Biochemical and biophysical research communications.

[54]  J. -. Martin,et al.  Analysis of conjugated linoleic acid isomers and content in french cheeses , 1998 .

[55]  R. G. Jensen,et al.  The Anticarcinogenic Conjugated Fatty Acid, 9c, 11t-18:2, in Human Milk: Confirmation of Its Presence , 1998, Journal of human lactation : official journal of International Lactation Consultant Association.

[56]  M. Jauhiainen,et al.  Dietary trans fatty acids increase conjugated linoleic acid levels in human serum , 1998 .

[57]  M. McGuire,et al.  Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. , 1998, The American journal of clinical nutrition.

[58]  M. Mossoba,et al.  Silver-ion high-performance liquid chromatographic separation and identification of conjugated linoleic acid isomers , 1998, Lipids.

[59]  S. Banni,et al.  Conjugated linoleic acid and oxidative stress , 1998 .

[60]  A. Nanji,et al.  Dietary saturated fatty acids down‐regulate cyclooxygenase‐2 and tumor necrosis factor alfa and reverse fibrosis in alcohol‐induced liver disease in the rat , 1997, Hepatology.

[61]  A. Schaefer,et al.  The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs , 1997 .

[62]  F M Maciel,et al.  Induction of cyclooxygenase-2 by parathyroid hormone in human osteoblasts in culture. , 1997, The Journal of rheumatology.

[63]  A. Zhang,et al.  Oxidative stability of conjugated linoleic acids relative to other polyunsaturated fatty acids , 1997 .

[64]  H. Steinhart,et al.  Conjugated linoleic acid (CLA) isomers in human adipose tissue , 1997 .

[65]  R. Fondén,et al.  Conjugated Linoleic Acid in Swedish dairy products with special reference to the manufacture of hard cheeses , 1997 .

[66]  H. Thompson,et al.  Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. , 1997, Cancer research.

[67]  M. Mossoba,et al.  Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids , 1997, Lipids.

[68]  M. Belury,et al.  Dietary conjugated linoleic acid induces peroxisome-specific enzyme accumulation and ornithine decarboxylase activity in mouse liver , 1997 .

[69]  Hans Steinhart,et al.  Conjugated linoleic acid in milk fat: High variation depending on production system , 1997 .

[70]  C. Stanton,et al.  Dietary Influences on Bovine Milk cis‐9,trans‐11‐Conjugated Linoleic Acid Content , 1997 .

[71]  M. Cook,et al.  Effect of conjugated linoleic acid on body composition in mice , 1997, Lipids.

[72]  M. McGuire,et al.  CONJUGATED LINOLEIC ACID CONCENTRATIONS OF HUMAN MILK AND INFANT FORMULA , 1997 .

[73]  P. Parodi.  Cows' milk fat components as potential anticarcinogenic agents. , 1997, The Journal of nutrition.

[74]  S. Josyula,et al.  DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. , 1997, Mutation research.

[75]  Cheng Jiang,et al.  Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis. , 1997, Carcinogenesis.

[76]  J. Chardigny,et al.  Metabolites of conjugated isomers of linoleic acid (CLA) in the rat. , 1997, Biochimica et biophysica acta.

[77]  T. Wong,et al.  Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. , 1997, Anticancer research.

[78]  A. Cesano,et al.  Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. , 1997, Anticancer research.

[79]  M. Belury,et al.  Conjugated linoleic acid modulates hepatic lipid composition in mice , 1997, Lipids.

[80]  C. Steinhart.  Conjugated Linoleic Acid The Good News about Animal Fat , 1996 .

[81]  L. Bonewald,et al.  Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[82]  A. Lichtenstein,et al.  Position paper on trans fatty acids. ASCN/AIN Task Force on Trans Fatty Acids. American Society for Clinical Nutrition and American Institute of Nutrition. , 1996, The American journal of clinical nutrition.

[83]  H. Thompson,et al.  The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. , 1996, Carcinogenesis.

[84]  A. Aromaa,et al.  Intake of dairy products and the risk of breast cancer. , 1996, British Journal of Cancer.

[85]  R. Fondén,et al.  Occurrence of conjugated cis-9,trans-11-octadecadienoic acid in bovine milk: effects of feed and dietary regimen. , 1996, Journal of dairy science.

[86]  S. Banni,et al.  Characterization of conjugated diene fatty acids in milk, dairy products, and lamb tissues , 1996 .

[87]  M. Pariza,et al.  Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. , 1995, Carcinogenesis.

[88]  L. Luedecke,et al.  Survey of the conjugated linoleic acid contents of dairy products. , 1995, Journal of dairy science.

[89]  C. L. Hicks,et al.  Conjugated Linoleic Acid Concentrations in Dairy Products as Affected by Processing and Storage , 1995 .

[90]  H. Krokan,et al.  The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. , 1995, Anticancer research.

[91]  R. Wolff.  Content and distribution oftrans-18:1 acids in ruminant milk and meat fats. Their importance in european diets and their effect on human milk , 1995 .

[92]  R. Evans,et al.  Liquid chromatographic-mass spectrometric analysis of conjugated diene fatty acids in a partially hydrogenated fat , 1994 .

[93]  M. Pariza,et al.  Conversion of allylic hydroxy oleate to conjugated linoleic acid and methoxy oleate by acid-catalyzed methylation procedures , 1994 .

[94]  E. Decker,et al.  Evaluation of conjugated linoleic acid concentrations in cooked beef , 1994 .

[95]  K. N. Lee,et al.  Conjugated linoleic acid and atherosclerosis in rabbits. , 1994, Atherosclerosis.

[96]  M. Pariza,et al.  Conjugated linoleic acid (9,11- and 10,12-octadecadienoic acid) is produced in conventional but not germ-free rats fed linoleic acid. , 1994, The Journal of nutrition.

[97]  Meenakshi Singh,et al.  Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. , 1994, Cancer research.

[98]  L. Luedecke,et al.  Effect of cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men , 1994 .

[99]  C. Miller,et al.  Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. , 1994, Biochemical and biophysical research communications.

[100]  C. Miller,et al.  Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. , 1993, Poultry science.

[101]  B. Hennig,et al.  Comparison of methylation methods for the quantitation of conjugated linoleic acid isomers , 1993 .

[102]  J. Manson,et al.  Intake of trans fatty acids and risk of coronary heart disease among women , 1993, The Lancet.

[103]  B. Chew,et al.  Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. , 1992, Anticancer research.

[104]  L. Luedecke,et al.  Determination of conjugated linoleic acid content and isomer distribution in three Cheddar-type cheeses: effects of cheese cultures, processing, and aging , 1992 .

[105]  M. Pariza,et al.  Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens , 1992 .

[106]  E. Decker,et al.  Conjugated linoleic acid concentration in processed cheese , 1992 .

[107]  C. Ip,et al.  Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. , 1991, Cancer research.

[108]  M. Mossoba,et al.  Identification of minor C18 triene and conjugated diene isomers in hydrogenated soybean oil and margarine by GC-MI-FT-IR spectroscopy. , 1991, Journal of chromatographic science.

[109]  T. Slaga,et al.  Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin. , 1991, Cancer research.

[110]  M. Pariza,et al.  Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. , 1990, Cancer research.

[111]  R. Farrell,et al.  Effects of D,L-2-difluoromethylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets. , 1989, Cancer research.

[112]  U. Schuchardt,et al.  Tetramethylguanidine catalyzed transesterification of fats and oils: A new method for rapid determination of their composition , 1988 .

[113]  M. Pariza,et al.  Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. , 1987, Carcinogenesis.

[114]  M. Pariza,et al.  A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene. , 1985, Carcinogenesis.

[115]  D. B. Lund,et al.  Effects of temperature and time on mutagen formation in pan-fried hamburger. , 1979, Cancer letters.

[116]  W. Christie,et al.  Changes in the rumen metabolism of sheep given increasing amounts of linseed oil in their diet , 1975, British Journal of Nutrition.

[117]  L. D. Metcalfe,et al.  Rapid Preparation of Fatty Acid Esters from Lipids for Gas Chromatographic Analysis. , 1966 .

[118]  L. D. Metcalfe,et al.  The Rapid Preparation of Fatty Acid Esters for Gas Chromatographic Analysis , 1961 .

[119]  W. Moore,et al.  Distribution of Butyrivibrio Fibrisolvens in Nature , 1960 .

[120]  C. Ip,et al.  An increase in vitamin A status by the feeding of conjugated linoleic acid. , 1999, Nutrition and cancer.

[121]  M. Belury,et al.  Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. , 1999, Nutrition and cancer.

[122]  S. Josyula,et al.  Inhibition of DNA adduct formation of PhIP in female F344 rats by dietary conjugated linoleic acid. , 1998, Nutrition and cancer.

[123]  S. Narumiya,et al.  Prostaglandin E2 (PGE2) Autoamplifies its Production Through EP1 Subtype of PGE Receptor in Mouse Osteoblastic MC3T3-E1 Cells , 1998, Calcified Tissue International.

[124]  D. Kritchevsky,et al.  Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. , 1997 .

[125]  R. Nicolosi,et al.  Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. , 1997, Artery.

[126]  C. Ip,et al.  Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. , 1997, Nutrition and cancer.

[127]  H. Ly,et al.  Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. , 1997 .

[128]  M. Belury,et al.  Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. , 1996, Nutrition and cancer.

[129]  E. Decker,et al.  Conjugated linoleic acid concentrations in processed cheese containing hydrogen donors, iron and dairy-based additives , 1993 .

[130]  G. Burton,et al.  Antioxidant action of carotenoids. , 1989, The Journal of nutrition.

[131]  M. Pariza,et al.  Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses , 1989 .

[132]  M. Hirose,et al.  Antioxidants--carcinogenic and chemopreventive properties. , 1989, Advances in cancer research.

[133]  D. G. Chapman,et al.  Butter Adulteration, Detection of Hydrogenated Fats in Butter Fat by Measurement of cis-trans Conjugated Unsaturation , 1961 .