Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule.

[1]  D. Weiner,et al.  DNA vaccines for HIV: challenges and opportunities , 2006, Springer Seminars in Immunopathology.

[2]  D. Weiner,et al.  Independence of granzyme B secretion and interferon- gamma production during acute simian immunodeficiency virus infection. , 2006, The Journal of infectious diseases.

[3]  Lieping Chen,et al.  Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. , 2005, Vaccine.

[4]  R. Siliciano,et al.  DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication. , 2005, Virology.

[5]  Fumito Ito,et al.  Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-Based Vaccines , 2004, Cancer Research.

[6]  R. Hansen,et al.  Antibody pharmacokinetics and pharmacodynamics. , 2004, Journal of pharmaceutical sciences.

[7]  A. Weinberg,et al.  4‐1BB and OX40 stimulation enhance CD8 and CD4 T‐cell responses to a DNA prime, poxvirus boost vaccine , 2004, Immunology.

[8]  D. Weiner,et al.  Enhancement of human immunodeficiency virus type 1‐DNA vaccine potency through incorporation of T‐helper 1 molecular adjuvants , 2004, Immunological reviews.

[9]  Ji Hee Son,et al.  Humanization of Antagonistic Anti-Human 4-1BB Monoclonal Antibody Using a Phage-Displayed Combinatorial Library , 2004, Journal of immunotherapy.

[10]  Ji Hee Son,et al.  Humanization of agonistic anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial library. , 2004, Journal of immunological methods.

[11]  M. McCausland,et al.  Anti-CD137 antibodies in the treatment of autoimmune disease and cancer , 2004, Immunologic research.

[12]  M. Croft.  Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? , 2003, Nature Reviews Immunology.

[13]  B. Kwon,et al.  4-1BB cross-linking enhances the survival and cell cycle progression of CD4 T lymphocytes. , 2003, Cellular immunology.

[14]  D. Weiner,et al.  T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev , 2002, AIDS.

[15]  Sujung Park,et al.  4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-11 , 2002, The Journal of Immunology.

[16]  N. Boiani,et al.  4-1BB-Specific Monoclonal Antibody Promotes the Generation of Tumor-Specific Immune Responses by Direct Activation of CD8 T Cells in a CD40-Dependent Manner , 2002, The Journal of Immunology.

[17]  Lieping Chen,et al.  Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. , 2002, Cancer research.

[18]  S. Thung,et al.  T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer , 2002, Gene Therapy.

[19]  Lieping Chen,et al.  Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells1 , 2002, The Journal of Immunology.

[20]  K. Takeda,et al.  Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. , 2002, International immunology.

[21]  David Allman,et al.  Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB , 2002, Nature Biotechnology.

[22]  Henryk Mach,et al.  Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity , 2002, Nature.

[23]  A. McMichael,et al.  A DNA/MVA-based candidate human immunodeficiency virus vaccine for Kenya induces multi-specific T cell responses in rhesus macaques. , 2002, The Journal of general virology.

[24]  J. Altman,et al.  In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses , 2002, Nature Immunology.

[25]  Lieping Chen,et al.  Anti-4-1 BB Monoclonal Antibody Enhances Rejection of Large Tumor Burden by Promoting Survival but not Clonal Expansion of Tumor-specific CD 8 T Cells 1 , 2002 .

[26]  Lieping Chen,et al.  Amelioration of Experimental Autoimmune Monoclonal Antibody Leads to the Administration of Agonistic Anti-4-1BB , 2002 .

[27]  S. Calarota,et al.  Gene combination raises broad human immunodeficiency virus-specific cytotoxicity. , 2001, Human gene therapy.

[28]  James G. Herndon,et al.  Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine , 2001, Science.

[29]  R. Papay,et al.  Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation. , 2001, Cancer research.

[30]  Y. J. Kang,et al.  A Humanized Anti–4-1BB Monoclonal Antibody Suppresses Antigen-Induced Humoral Immune Response in Nonhuman Primates , 2000, Journal of immunotherapy.

[31]  A. Sette,et al.  4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination1 , 2000, The Journal of Immunology.

[32]  R. Mittler,et al.  Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy , 1999, The Journal of experimental medicine.

[33]  R. Ahmed,et al.  4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. , 1999, Journal of immunology.

[34]  E. Sandström,et al.  Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. , 1999, Journal of immunology.

[35]  C. Takahashi,et al.  Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. , 1999, Journal of immunology.

[36]  D. Montefiori,et al.  Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. , 1999, Science.

[37]  F. Sallusto,et al.  Two subsets of memory T lymphocytes with distinct homing potentials and effector functions , 1999, Nature.

[38]  Lieping Chen,et al.  NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. , 1998, Cellular immunology.

[39]  D. Weiner,et al.  First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. , 1998, The Journal of infectious diseases.

[40]  T. Mak,et al.  CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand , 1998, The Journal of experimental medicine.

[41]  E. Sandström,et al.  Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients , 1998, The Lancet.

[42]  A. Aruffo,et al.  4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses , 1997, The Journal of experimental medicine.

[43]  Lieping Chen,et al.  Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors , 1997, Nature Medicine.

[44]  B. Kwon,et al.  Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. , 1997, Journal of immunology.

[45]  T. Mak,et al.  Costimulation of CD28- T lymphocytes by 4-1BB ligand. , 1997, Journal of immunology.

[46]  J. Margolick,et al.  Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. , 1995, The New England journal of medicine.

[47]  D. Ho,et al.  Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. , 1995, The New England journal of medicine.

[48]  G. Sutherland,et al.  Moslecular and biological characterization of human 4‐1BB and its ligands , 1994, European journal of immunology.

[49]  K. Pollok,et al.  4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells , 1994, European journal of immunology.

[50]  N. Copeland,et al.  Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor , 1993, European journal of immunology.

[51]  K. Pollok,et al.  Inducible T cell antigen 4-1BB. Analysis of expression and function. , 1993, Journal of immunology.