Potential Applications of Pulsating Joint Loading inSports Medicine

Because bone is responsive to mechanical loading, pulsating joint loading (PJL), which laterally applies oscillatory mechanical loads to joints, can be explored for preventive conditioning and therapeutic treatments. Herein, the general features of PJL are reviewed, and its potential usage for sports medicine is discussed.

[1]  I. Gérin,et al.  Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ* , 2007, Journal of Biological Chemistry.

[2]  H. Yokota,et al.  Effects of surgical holes in mouse tibiae on bone formation induced by knee loading. , 2007, Bone.

[3]  Ping Zhang,et al.  Knee loading dynamically alters intramedullary pressure in mouse femora. , 2007, Bone.

[4]  R. Daly.  The effect of exercise on bone mass and structural geometry during growth. , 2007, Medicine and sport science.

[5]  J. Beaudreuil.  Traitements non médicamenteux de l'ostéoporose , 2006 .

[6]  C. Hermenegildo,et al.  The risk for cardiovascular disease in women: from estrogens to selective estrogen receptor modulators. , 2007, Frontiers in bioscience : a journal and virtual library.

[7]  Qiwei Sun,et al.  Knee Loading Accelerates Bone Healing in Mice , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  Katarina T. Borer,et al.  Physical Activity in the Prevention and Amelioration of Osteoporosis in Women , 2005, Sports medicine.

[9]  A. Robling,et al.  Exercises for improving bone strength , 2005, British Journal of Sports Medicine.

[10]  B. Mitlak.  Parathyroid hormone as a therapeutic agent. , 2002, Current opinion in pharmacology.

[11]  Hao Jiang,et al.  Diaphyseal bone formation in murine tibiae in response to knee loading , 2006, Journal of applied physiology.

[12]  J. Iwamoto,et al.  Stress fractures in athletes: review of 196 cases , 2003, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[13]  C. Benhamou.  Effects of osteoporosis medications on bone quality. , 2007, Joint, bone, spine : revue du rhumatisme.

[14]  S. Usami,et al.  Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow , 2006, Journal of cellular biochemistry.

[15]  M. Petit,et al.  Lessons learned from school-based skeletal loading intervention trials: putting research into practice. , 2007, Medicine and sport science.

[16]  K. Lau,et al.  Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear* , 2006, Journal of Biological Chemistry.

[17]  F. Chan,et al.  Drug-induced side effects affecting the gastrointestinal tract , 2006, Expert opinion on drug safety.

[18]  Tetsuji Yamamoto,et al.  Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. , 2007, Bone.

[19]  C. Rubin,et al.  Anabolism: Low mechanical signals strengthen long bones , 2001, Nature.

[20]  Y. Umemura,et al.  Five Jumps per Day Increase Bone Mass and Breaking Force in Rats , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  M. Niva,et al.  Fatigue injuries of the femur. , 2005, The Journal of bone and joint surgery. British volume.

[22]  D. Mcallister,et al.  Evaluation and treatment of tibial stress fractures. , 2006, Clinics in sports medicine.

[23]  C. Turner,et al.  Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz. , 2004, Bone.

[24]  Nobuou Matsusaka,et al.  Feasibility and effectiveness of a nurse-led community exercise programme for prevention of falls among frail elderly people: a multi-centre controlled trial. , 2007, Journal of rehabilitation medicine.

[25]  Mark L. Johnson,et al.  Osteocytes, mechanosensing and Wnt signaling. , 2008, Bone.

[26]  Osteogenic potentials with joint-loading modality , 2005, Journal of Bone and Mineral Metabolism.

[27]  M. Forwood,et al.  Cyclooxygenase-2 Inhibition Delays the Attainment of Peak Woven Bone Formation following Four-Point Bending in the Rat , 2007, Calcified Tissue International.

[28]  C. Turner,et al.  Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading , 2007, Journal of Bone and Mineral Metabolism.

[29]  Ping Zhang,et al.  Knee-Loading Modality Drives Molecular Transport in Mouse Femur , 2006, Annals of Biomedical Engineering.