A medicament cartridge dry powder (150) for a dry powder inhaler comprising: (a) a top of the cartridge (152) having at least one dispensing port (127); and (b) a cartridge bottom (151), portions of which define an interior volume; wherein the cartridge top has an undersurface that extends over the bottom of the cartridge, with an area (154) for sealing off the interior volume and area (168) to expose the internal volume to ambient air; wherein the bottom of the cartridge to the bottom surface for movement relative to the top of the cartridge is fixed by a translational motion and can be configured to attain a containment position, wherein the bottom surface closes sealed inside volume to form an enclosure configured to contain the drug and to restrict the entry of air inside volume, and a dispensing position or dosage, wherein the cartridge top and the cartridge bottom are at least one input port (119) allowing air flow into the interior volume in response to a pressure differential and wherein the at least one dispensing port (127) is located on the inner volume.