3D-printed scaffolds based on PLA/HA nanocomposites for trabecular bone reconstruction

In the present work porous PLA scaffolds filled with micro- and nano- HA were studied. Both composites with micro- and nano-HA were obtained by extrusion in the same conditions. Scaffolds were obtained by 3D-printing by fused filament fabrication method. Structure of porous scaffolds was pre-modeled by computer software. Compression and three - point flexural tests were used to study mechanical properties of the scaffolds.

[1]  Chaoliang He,et al.  Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility. , 2005, Biomaterials.

[2]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[3]  S. Hollister Porous scaffold design for tissue engineering , 2005, Nature materials.

[4]  Youssef Habibi,et al.  Polylactide (PLA)-based nanocomposites , 2013 .

[5]  A. A. Baranov,et al.  Microstructure and properties of composite materials based on UHMWPE after mechanical activation , 2014 .

[6]  J. Tanaka,et al.  Preparation and mechanical properties of calcium phosphate/copoly-L-lactide composites , 1997, Journal of materials science. Materials in medicine.

[7]  J. Planell,et al.  High-resolution PLA-based composite scaffolds via 3-D printing technology. , 2013, Acta biomaterialia.

[8]  W. Stark,et al.  Improved degradation and bioactivity of amorphous aerosol derived tricalcium phosphate nanoparticles in poly(lactide-co-glycolide) , 2006 .

[9]  S. Goldstein The mechanical properties of trabecular bone: dependence on anatomic location and function. , 1987, Journal of biomechanics.

[10]  Lorenzo Moroni,et al.  Biomaterials engineered for integration , 2008 .

[11]  F. Senatov,et al.  Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds. , 2016, Journal of the mechanical behavior of biomedical materials.

[12]  Dietmar Werner Hutmacher,et al.  State of the art and future directions of scaffold‐based bone engineering from a biomaterials perspective , 2007, Journal of tissue engineering and regenerative medicine.