Bioreactors in tissue engineering.

A bioreactor can be defined as a device that uses mechanical means to influence biological processes. In tissue engineering bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This chapter discusses the necessity for bioreactors in tissue engineering, the numerous types of bioreactor that exist, the means by which they stimulate cells and how their functionality is governed by the requirements of the specific tissue being engineered and the cell type undergoing stimulation.

[1]  H J Donahue,et al.  Differential effect of steady versus oscillating flow on bone cells. , 1998, Journal of biomechanics.

[2]  Robert E Guldberg,et al.  Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. , 2003, Tissue engineering.

[3]  A. Goldstein,et al.  Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner. , 2005, Bone.

[4]  Ivan Martin,et al.  The FASEB Journal express article 10.1096/fj.01-0656fje. Published online December 28, 2001. Cell differentiation by mechanical stress , 2022 .

[5]  E H Burger,et al.  Pulsating Fluid Flow Stimulates Prostaglandin Release and Inducible Prostaglandin G/H Synthase mRNA Expression in Primary Mouse Bone Cells , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  Milica Radisic,et al.  Medium perfusion enables engineering of compact and contractile cardiac tissue. , 2004, American journal of physiology. Heart and circulatory physiology.

[7]  P. E. McHugh,et al.  Bioreactors for Cardiovascular Cell and Tissue Growth: A Review , 2003, Annals of Biomedical Engineering.

[8]  Christopher R Jacobs,et al.  Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. , 2005, Journal of biomechanics.

[9]  Fergal J O'Brien,et al.  Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds. , 2004, Biomaterials.

[10]  Vassilios Sikavitsas,et al.  Tissue Engineering Bioreactors , 2006 .

[11]  F. O'Brien,et al.  Part 1: scaffolds and surfaces. , 2008, Technology and health care : official journal of the European Society for Engineering and Medicine.

[12]  S E Carver,et al.  Semi-continuous perfusion system for delivering intermittent physiological pressure to regenerating cartilage. , 1999, Tissue engineering.

[13]  Mechanical stimulation of osteoblasts using steady and dynamic fluid flow. , 2008 .

[14]  D. Wolf,et al.  Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity. , 1992, Journal of tissue culture methods : Tissue Culture Association manual of cell, tissue, and organ culture procedures.

[15]  A. Mikos,et al.  Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. , 2001, Biomaterials.

[16]  F. O'Brien,et al.  Stimulation of osteoblasts using rest periods during bioreactor culture on collagen-glycosaminoglycan scaffolds , 2010, Journal of materials science. Materials in medicine.

[17]  R Langer,et al.  Dynamic Cell Seeding of Polymer Scaffolds for Cartilage Tissue Engineering , 1998, Biotechnology progress.

[18]  G. Vunjak‐Novakovic,et al.  Tissue engineering of cartilage in space. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Farshid Guilak,et al.  Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. , 2006, Tissue engineering.

[20]  R. Langer,et al.  Biomaterials in drug delivery and tissue engineering: one laboratory's experience. , 2000, Accounts of chemical research.

[21]  J A Frangos,et al.  Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts. , 1991, The American journal of physiology.

[22]  F J Schoen,et al.  Functional Living Trileaflet Heart Valves Grown In Vitro , 2000, Circulation.

[23]  D. Wendt,et al.  The role of bioreactors in tissue engineering. , 2004, Trends in biotechnology.

[24]  Albert J Banes,et al.  Novel system for engineering bioartificial tendons and application of mechanical load. , 2003, Tissue engineering.

[25]  C. Perry,et al.  Bone repair techniques, bone graft, and bone graft substitutes. , 1999, Clinical orthopaedics and related research.

[26]  Patrick J. Prendergast,et al.  Regulatory Effects of Mechanical Strain on the Chondrogenic Differentiation of MSCs in a Collagen-GAG Scaffold: Experimental and Computational Analysis , 2008, Annals of Biomedical Engineering.

[27]  M J Yaszemski,et al.  Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. , 1997, Journal of biomedical materials research.

[28]  J. Glowacki,et al.  Perfusion Enhances Functions of Bone Marrow Stromal Cells in Three-Dimensional Culture , 1998 .

[29]  Sara Mantero,et al.  Clinical transplantation of a tissue-engineered airway , 2008, The Lancet.

[30]  Patrick Vermette,et al.  Bioreactors for tissue mass culture: design, characterization, and recent advances. , 2005, Biomaterials.

[31]  M. Radisic,et al.  Feasibility study of a novel urinary bladder bioreactor. , 2007, Tissue engineering. Part A.

[32]  Ian A. Coe,et al.  Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[33]  Yubo Sun,et al.  Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone‐Marrow Derived Mesenchymal Stem Cells , 2004, Stem cells.

[34]  Cato T Laurencin,et al.  Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  G A Ateshian,et al.  Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. , 2000, Journal of biomechanical engineering.

[36]  S. Mizuno,et al.  Hydrostatic pressure/perfusion culture system designed and validated for engineering tissue. , 2005, Journal of bioscience and bioengineering.

[37]  S. Donahue,et al.  Mechanical stimulation of MC3T3 osteoblastic cells in a bone tissue-engineering bioreactor enhances prostaglandin E2 release. , 2005, Tissue engineering.

[38]  R Langer,et al.  Morphology and mechanical function of long-term in vitro engineered cartilage. , 1999, Journal of biomedical materials research.

[39]  Clemens A van Blitterswijk,et al.  A perfusion bioreactor system capable of producing clinically relevant volumes of tissue-engineered bone: in vivo bone formation showing proof of concept. , 2005, Biomaterials.

[40]  H J Donahue,et al.  Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3–E1 Osteoblasts* , 2001, The Journal of Biological Chemistry.

[41]  Antonios G. Mikos,et al.  Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[42]  S. Thorpe,et al.  Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. , 2008, Biochemical and biophysical research communications.

[43]  Kyriacos A. Athanasiou,et al.  Biomechanical Strategies for Articular Cartilage Regeneration , 2003, Annals of Biomedical Engineering.

[44]  R Langer,et al.  Functional arteries grown in vitro. , 1999, Science.

[45]  R. Ian Freshney,et al.  Culture of Animal Cells , 1983 .

[46]  Fergal J O'Brien,et al.  Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds. , 2008, Journal of biotechnology.

[47]  Antonios G Mikos,et al.  Design of a flow perfusion bioreactor system for bone tissue-engineering applications. , 2003, Tissue engineering.

[48]  P. Tresco,et al.  Design and validation of a bioreactor for engineering vocal fold tissues under combined tensile and vibrational stresses. , 2004, Journal of biomechanics.

[49]  Kyriacos A Athanasiou,et al.  Articular cartilage bioreactors and bioprocesses. , 2003, Tissue engineering.

[50]  R J Cohen,et al.  Cardiac muscle tissue engineering : toward an in vitro model for electrophysiological studies , 1999 .

[51]  I R Titze,et al.  On the relation between subglottal pressure and fundamental frequency in phonation. , 1989, The Journal of the Acoustical Society of America.

[52]  B. A. Byers,et al.  Regulation of Cartilaginous ECM Gene Transcription by Chondrocytes and MSCs in 3D Culture in Response to Dynamic Loading , 2007, Biomechanics and modeling in mechanobiology.

[53]  R Langer,et al.  Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. , 2001, American journal of physiology. Heart and circulatory physiology.

[54]  R. Levy,et al.  Initiation of mineralization in bioprosthetic heart valves: studies of alkaline phosphatase activity and its inhibition by AlCl3 or FeCl3 preincubations. , 1991, Journal of biomedical materials research.

[55]  Frédéric Couet,et al.  Design of a perfusion bioreactor specific to the regeneration of vascular tissues under mechanical stresses. , 2005, Artificial organs.

[56]  M J Yaszemski,et al.  Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. , 1998, Biomaterials.

[57]  Gordana Vunjak-Novakovic,et al.  CHAPTER 13 – TISSUE ENGINEERING BIOREACTORS , 2000 .

[58]  Frederic Martini,et al.  Fundamentals of Anatomy and Physiology , 1997 .

[59]  F. O'Brien,et al.  Osteoblast response to rest periods during bioreactor culture of collagen-glycosaminoglycan scaffolds. , 2010, Tissue engineering. Part A.