Effect of metabolic level of the host upon the pathogenesis of rabies in the bat.

Recognition in 1953 of the presence of rabies in insectivorous bats of the United States stimulated interest in the relationship of their unique physiological characteristics to the pathogenesis of viral disease. Ito and Saito (1952) had previously reported a prolonged infection of the brain of Pipistrellus abramus, but an absence of viremia or antibody response to intracerebral inoculation with Japanese B encephalitis virus during hibernation. They found that these animals developed brain titers of 102 ,

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