Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner

[1]  W. Kong,et al.  Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰ , 2019, EBioMedicine.

[2]  Hongyuan Yang,et al.  The biogenesis of lipid droplets: Lipids take center stage. , 2019, Progress in lipid research.

[3]  D. Bernlohr,et al.  Adipose oxidative stress and protein carbonylation , 2018, The Journal of Biological Chemistry.

[4]  Xian Wang,et al.  Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis , 2018, Redox biology.

[5]  D. Veale,et al.  Hypoxia, oxidative stress and inflammation. , 2018, Free radical biology & medicine.

[6]  W. Kong,et al.  Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance , 2018, EBioMedicine.

[7]  B. Geng,et al.  Spontaneous development of hepatosteatosis in perilipin-1 null mice with adipose tissue dysfunction. , 2018, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[8]  Peng Li,et al.  Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions , 2018, The Journal of cell biology.

[9]  Rong Yu,et al.  A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease , 2017, Lipids in Health and Disease.

[10]  Yi Fu,et al.  Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets , 2017, British journal of pharmacology.

[11]  Changtao Jiang,et al.  Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice , 2016, Hepatology.

[12]  A. Diehl,et al.  Pathogenesis of Nonalcoholic Steatohepatitis. , 2016, Gastroenterology.

[13]  D. Langin,et al.  Adipocyte lipolysis and insulin resistance. , 2016, Biochimie.

[14]  H. Fotbolcu,et al.  Nonalcoholic fatty liver disease as a multi-systemic disease. , 2016, World journal of gastroenterology.

[15]  O. Kuda,et al.  Major role of adipocyte prostaglandin E2 in lipolysis-induced macrophage recruitment[S] , 2016, Journal of Lipid Research.

[16]  Zhenyuan Song,et al.  Adipose tissue-liver axis in alcoholic liver disease. , 2016, World journal of gastrointestinal pathophysiology.

[17]  Sheng-chao Ma,et al.  High‐methionine diets accelerate atherosclerosis by HHcy‐mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/− mice , 2015, FEBS letters.

[18]  L. Pu,et al.  Quercetin Increases Hepatic Homocysteine Remethylation and Transsulfuration in Rats Fed a Methionine-Enriched Diet , 2015, BioMed research international.

[19]  H. Friess,et al.  Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer , 2015, Oncotarget.

[20]  Lei Wang,et al.  Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. , 2015, Free radical biology & medicine.

[21]  C. Thorpe,et al.  Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum. , 2015, Free radical biology & medicine.

[22]  B. Viollet,et al.  Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo , 2015, Nature Medicine.

[23]  P. Ganguly,et al.  Role of homocysteine in the development of cardiovascular disease , 2015, Nutrition Journal.

[24]  M. Jeschke,et al.  Endoplasmic reticulum stress in adipose tissue augments lipolysis , 2014, Journal of cellular and molecular medicine.

[25]  M. Trauner,et al.  Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD , 2014, Trends in Endocrinology & Metabolism.

[26]  Joseph E Chambers,et al.  Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress. , 2014, American journal of physiology. Cell physiology.

[27]  C. Hetz,et al.  Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview. , 2014, American journal of physiology. Cell physiology.

[28]  J. Chen,et al.  Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease , 2014, British journal of pharmacology.

[29]  E. Chevet,et al.  Redox controls UPR to control redox , 2014, Journal of Cell Science.

[30]  N. Møller,et al.  Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. , 2014, Journal of molecular endocrinology.

[31]  J. Greenson,et al.  Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. , 2013, Gastroenterology.

[32]  W. Kong,et al.  Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue* , 2013, The Journal of Biological Chemistry.

[33]  Fei Li,et al.  Hypoxia-inducible Factor 1α Regulates a SOCS3-STAT3-Adiponectin Signal Transduction Pathway in Adipocytes* , 2012, The Journal of Biological Chemistry.

[34]  A. S. Juncker,et al.  Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response , 2012, The Journal of Biological Chemistry.

[35]  Hong Chen,et al.  Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. , 2012, Journal of hepatology.

[36]  Guenter Haemmerle,et al.  FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling , 2012, Cell metabolism.

[37]  Jingna 邓敬 Deng 娜,et al.  Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells* , 2012, The Journal of Biological Chemistry.

[38]  O. Gavrilova,et al.  Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice , 2011, Diabetes.

[39]  Yanling Wu,et al.  Molecular cloning and characterization of the porcine Ero1L and ERp44 genes: potential roles in controlling energy metabolism. , 2011, General and comparative endocrinology.

[40]  G. Frühbeck,et al.  Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity , 2011, PloS one.

[41]  R. Zechner,et al.  Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. , 2010, The Journal of clinical investigation.

[42]  F. Hou,et al.  Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes. , 2009, American journal of physiology. Endocrinology and metabolism.

[43]  J. Krakoff,et al.  Macrophage Content in Subcutaneous Adipose Tissue , 2009, Diabetes.

[44]  Yi Liang,et al.  Reconstitution of human Ero1-Lalpha/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomerase. , 2009, The Journal of biological chemistry.

[45]  B. Wouters,et al.  Hypoxia signalling through mTOR and the unfolded protein response in cancer , 2008, Nature Reviews Cancer.

[46]  Xian Wang,et al.  Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro , 2008, Diabetes.

[47]  R. Zechner,et al.  Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism* , 2006, Journal of Biological Chemistry.

[48]  B. Ebert,et al.  Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo , 2006 .

[49]  M. Hori,et al.  AMP-Activated Protein Kinase Protects Cardiomyocytes against Hypoxic Injury through Attenuation of Endoplasmic Reticulum Stress , 2005, Molecular and Cellular Biology.

[50]  E. Çakır,et al.  Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non‐alcoholic fatty liver disease , 2005, Journal of gastroenterology and hepatology.

[51]  Shi-yao Chen,et al.  Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. , 2005, Journal of hepatology.

[52]  J. Weissman,et al.  Oxidative protein folding in eukaryotes , 2004, The Journal of cell biology.

[53]  Ben-Ami Sela,et al.  Hyperhomocysteinemia as a component of syndrome X. , 2003, Metabolism: clinical and experimental.

[54]  M. Gassmann,et al.  Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells , 2003, Molecular and Cellular Biology.

[55]  D. Singer,et al.  Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. , 2001, Diabetes care.

[56]  B. Ahrén.  Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice. , 2001, Acta physiologica Scandinavica.

[57]  K. Alberti,et al.  Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes , 1996, Diabetologia.

[58]  Frank D. Gray,et al.  Hypoxia , 1964, The Yale Journal of Biology and Medicine.

[59]  H. Gilbert,et al.  Protein disulfide isomerase. , 1998, Methods in enzymology.