Intravenous ribavirin therapy for adenovirus pneumonia

We report on the effectiveness of intravenous ribavirin for severe adenoviral pneumonia in a 10‐month‐old male following orthotopic liver transplantation. On day 20 post‐transplantation, he developed high fever, marked respiratory compromise, and hypoxemia. The chest radiograph showed bilateral pulmonary infiltrates. Samples of bronchoalveolar lavage fluid grew adenovirus, serotype 1. Marked clinical and radiological improvement was noted after intravenous ribavirin therapy. A prospective clinical trial is needed to determine the efficacy of ribavirin therapy for severe adenovirus disease. Pediatr Pulmonol. 2000; 29:69–73. © 2000 Wiley‐Liss, Inc.

[1]  P. Piedra,et al.  Disseminated adenovirus disease in immunocompromised and immunocompetent children. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  J. Moreb,et al.  Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report. , 1998, The Journal of infection.

[3]  D. Teele,et al.  Fatal adenoviral disease in siblings. , 1998, The Pediatric infectious disease journal.

[4]  W. Rozenbaum,et al.  Ribavirin therapy for adenovirus pneumonia in an AIDS patient. , 1997, American journal of respiratory and critical care medicine.

[5]  G. Mccracken,et al.  Intravenous ribavirin therapy in a neonate with disseminated adenovirus infection undergoing extracorporeal membrane oxygenation: pharmacokinetics and clearance by hemofiltration. , 1997, The Journal of pediatrics.

[6]  D. Carrigan.  Adenovirus infections in immunocompromised patients. , 1997, The American journal of medicine.

[7]  M. Bergin,et al.  Intravenous ribavirin therapy for disseminated adenovirus infection. , 1995, The Pediatric infectious disease journal.

[8]  W. Lynn,et al.  Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin. , 1995, Thorax.

[9]  M. Jurado,et al.  Adenovirus-associated haemorrhagic cystitis after bone marrow transplantation successfully treated with intravenous ribavirin. , 1995, Bone Marrow Transplantation.

[10]  W. Kuis,et al.  Recovery from adenovirus pneumonia in a severe combined immunodeficiency patient treated with intravenous ribavirin. , 1995, Transplantation.

[11]  A. Nagler,et al.  Intravenous ribavirin therapy for adenovirus gastroenteritis after bone marrow transplantation. , 1995, Journal of pediatric gastroenterology and nutrition.

[12]  K. Cornetta,et al.  Failure of ribavirin to clear adenovirus infections in T cell-depleted allogeneic bone marrow transplantation. , 1994, Bone marrow transplantation.

[13]  H. Cushing,et al.  Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin. , 1993, Bone marrow transplantation.

[14]  J. W. Mcroberts,et al.  Adenovirus-associated hemorrhagic cystitis treated with intravenous ribavirin. , 1993, The Journal of urology.

[15]  Jerome J. Schentag,et al.  The fractional maximal effect method: a new way to characterize the effect of antibiotic combinations and other nonlinear pharmacodynamic interactions , 1993, Antimicrobial Agents and Chemotherapy.

[16]  E. Connor,et al.  Safety, tolerance, and pharmacokinetics of systemic ribavirin in children with human immunodeficiency virus infection , 1993, Antimicrobial Agents and Chemotherapy.

[17]  J. Hierholzer.  Adenoviruses in the immunocompromised host , 1992, Clinical Microbiology Reviews.

[18]  E. Sokal,et al.  Acute adenovirus hepatitis in liver transplant recipients. , 1992, The Journal of pediatrics.

[19]  T. Starzl,et al.  Adenovirus infection in pediatric liver transplant recipients. , 1992, The Journal of infectious diseases.

[20]  J. Leduc,et al.  Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. , 1991, The Journal of infectious diseases.

[21]  W. Cassano.  Intravenous ribavirin therapy for adenovirus cystitis after allogeneic bone marrow transplantation. , 1991, Bone marrow transplantation.

[22]  S. Lipson,et al.  Disseminated adenovirus infection with hepatic necrosis in patients with human immunodeficiency virus infection and other immunodeficiency states. , 1990, Reviews of infectious diseases.

[23]  N. Varki,et al.  Adenovirus hepatitis in two successive liver transplants in a child. , 1990, Archives of Pathology & Laboratory Medicine.

[24]  D. Katzenstein,et al.  Nosocomial adenovirus infections: molecular epidemiology of an outbreak due to adenovirus 3a. , 1988, The Journal of infectious diseases.

[25]  R. Arthur,et al.  Hemorrhagic cystitis associated with adenovirus infection in bone marrow transplantation. , 1986, Archives of internal medicine.

[26]  A. Shields,et al.  Adenovirus infections in patients undergoing bone-marrow transplantation. , 1985, The New England journal of medicine.

[27]  R. K. Robins,et al.  Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide , 1972, Science.

[28]  G. R. French,et al.  Fatal pneumonia associated with adenovirus type 7 in three military trainees. , 1972, The New England journal of medicine.

[29]  R. Chanock,et al.  Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. , 1969, American journal of epidemiology.