Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity.

[1]  A. Berns,et al.  Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M. Capecchi,et al.  Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[3]  B. Thyagarajan,et al.  Mammalian genomes contain active recombinase recognition sites. , 2000, Gene.

[4]  Andras Nagy,et al.  Cre recombinase: The universal reagent for genome tailoring , 2000, Genesis.

[5]  A. Bradley,et al.  Engineering Mouse Chromosomes with Cre-loxP: Range, Efficiency, and Somatic Applications , 2000, Molecular and Cellular Biology.

[6]  F. Guo,et al.  Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Greer,et al.  Targeting genes for self-excision in the germ line. , 1999, Genes & development.

[8]  U. Müller,et al.  Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis , 1999, Mechanisms of Development.

[9]  J. Rossant,et al.  "Cre"-ating mouse mutants-a meeting review on conditional mouse genetics. , 1999, Genes & development.

[10]  I. Saito,et al.  Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. , 1998, Gene.

[11]  B. Sauer.  Inducible gene targeting in mice using the Cre/lox system. , 1998, Methods.

[12]  S. O’Gorman,et al.  Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  G. Martin,et al.  Cre–mediated chromosome loss in mice , 1997, Nature Genetics.

[14]  Ralph Scully,et al.  Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage , 1997, Cell.

[15]  B. Sauer,et al.  Multiplex Cre/lox recombination permits selective site-specific DNA targeting to both a natural and an engineered site in the yeast genome. , 1996, Nucleic acids research.

[16]  R. Mulligan,et al.  A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[17]  P. Gruss,et al.  Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. , 1996, Nucleic acids research.

[18]  H. von Melchner,et al.  Self-deleting retrovirus vectors for gene therapy , 1996, Journal of virology.

[19]  K. Rajewsky,et al.  Conditional gene targeting. , 1996, The Journal of clinical investigation.

[20]  P. Angrand,et al.  Regulation of Cre recombinase activity by the synthetic steroid RU 486. , 1996, Nucleic acids research.

[21]  J. Nicolas,et al.  Transfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP site , 1996, Journal of virology.

[22]  F. Sablitzky,et al.  Inducible site-directed recombination in mouse embryonic stem cells. , 1996, Nucleic acids research.

[23]  A. Bradley,et al.  Chromosome engineering in mice , 1995, Nature.

[24]  M Aguet,et al.  Inducible gene targeting in mice , 1995, Science.

[25]  P. Chambon,et al.  Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Kingsman,et al.  A transient three-plasmid expression system for the production of high titer retroviral vectors. , 1995, Nucleic acids research.

[27]  J. Murray,et al.  Site-specific recombinases: tools for genome engineering. , 1993, Trends in genetics : TIG.

[28]  T Friedmann,et al.  Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[29]  B. Sauer,et al.  Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[30]  B. Mosinger,et al.  Targeted oncogene activation by site-specific recombination in transgenic mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Gossen,et al.  Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[32]  B. Sauer,et al.  Identification of cryptic lox sites in the yeast genome by selection for Cre-mediated chromosome translocations that confer multiple drug resistance. , 1992, Journal of molecular biology.

[33]  R. Bronson,et al.  Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene , 1991, Cell.

[34]  N. Henderson,et al.  Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. , 1990, The New biologist.

[35]  N. Henderson,et al.  Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Hoess,et al.  A mutational analysis of the bacteriophage P1 recombinase Cre. , 1987, Journal of molecular biology.

[37]  R. Hoess,et al.  The role of the loxP spacer region in P1 site-specific recombination. , 1986, Nucleic acids research.

[38]  D. Botstein,et al.  Genetic properties of chromosomally integrated 2μ plasmid DNA in yeast , 1982, Cell.

[39]  R. Hoess,et al.  P1 site-specific recombination: nucleotide sequence of the recombining sites. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[40]  N. Sternberg,et al.  Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. , 1981, Journal of molecular biology.

[41]  David Baltimore,et al.  A detailed model of reverse transcription and tests of crucial aspects , 1979, Cell.

[42]  D. Baltimore,et al.  In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of moloney murine leukemia virus , 1979, Cell.

[43]  H. Varmus,et al.  Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA , 1978, Cell.

[44]  F. Alt,et al.  Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. , 2001, Immunity.

[45]  R. Hoess,et al.  Evidence for a second conserved arginine residue in the integrase family of recombination proteins. , 1992, Protein engineering.