Ubiquitin signalling: what's in a chain?

When cellular proteins are attached to a Lys 48-linked polyubiquitin chain, the proteasome will usually degrade them. But attaching such a chain to a yeast transcription factor inhibits its activity without degradation, raising questions about how polyubiquitination regulates transcriptional activation and why the protein is spared destruction.

[1]  Philipp Stelter,et al.  Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation , 2003, Nature.

[2]  Thomas Kodadek,et al.  Recruitment of a 19S Proteasome Subcomplex to an Activated Promoter , 2002, Science.

[3]  R. Deshaies,et al.  Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. , 2003, Molecular cell.

[4]  C. Pickart,et al.  Ubiquitin in chains. , 2000, Trends in biochemical sciences.

[5]  M. Hochstrasser.  Ubiquitin-dependent protein degradation. , 1996, Annual review of genetics.

[6]  R. Deshaies,et al.  Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation , 2003, Nature Cell Biology.

[7]  M. Tyers,et al.  Feedback‐regulated degradation of the transcriptional activator Met4 is triggered by the SCFMet30 complex , 2000, The EMBO journal.

[8]  A. Caudy,et al.  Regulation of Transcriptional Activation Domain Function by Ubiquitin , 2001, Science.

[9]  E. Ezhkova,et al.  Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. , 2004, Molecular cell.

[10]  G. Dittmar,et al.  Proteasome subunit Rpn1 binds ubiquitin-like protein domains , 2002, Nature Cell Biology.

[11]  J. Yates,et al.  Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain , 2004, Nature Cell Biology.

[12]  S. Reed,et al.  Regulation of Transcription by Ubiquitination without Proteolysis Cdc34/SCFMet30-Mediated Inactivation of the Transcription Factor Met4 , 2000, Cell.

[13]  M. Muratani,et al.  How the ubiquitin–proteasome system controls transcription , 2003, Nature Reviews Molecular Cell Biology.

[14]  M. Tyers,et al.  Dual regulation of the met4 transcription factor by ubiquitin-dependent degradation and inhibition of promoter recruitment. , 2002, Molecular cell.

[15]  D. Ecker,et al.  A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. , 1989, Science.

[16]  Martin Rechsteiner,et al.  Recognition of the polyubiquitin proteolytic signal , 2000, The EMBO journal.