Molecular connectivity of phenols and their toxicity to fish

Reliable studies on the toxicity of a large number of compounds have recently become available to the scientific community from the Environmental Research Laboratory at Duluth, Minnesota, The Stanford Research Institute and the University of Wisconsin at Superior. This extensive database makes it possible to contact QSAR studies for the purpose of establishing structural relationships with toxicity in order to make predictions and possibly shed light on the mechanisms involved. One group of compounds, the phenols, are of particular interest due to their wide use and potential for environmental contamination. The purpose of this study is to relate the relative toxicity to the structure in an effort to make predictions about the toxic potentiality of other phenols.