The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions.

[1]  A. Georgakilas.  Detection of clustered DNA lesions: Biological and clinical applications. , 2011, World journal of biological chemistry.

[2]  David J. Chen,et al.  Unrepaired clustered DNA lesions induce chromosome breakage in human cells , 2011, Proceedings of the National Academy of Sciences.

[3]  J. Harper,et al.  Radiation induced DNA DSBs: Contribution from stalled replication forks? , 2010, DNA repair.

[4]  M. Lomax,et al.  Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage , 2009, Nucleic acids research.

[5]  L. Harrison,et al.  Apex1 can cleave complex clustered DNA lesions in cells. , 2009, DNA repair.

[6]  P. O'Neill,et al.  Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli. , 2009, Mutation research.

[7]  M. Lomax,et al.  Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic , 2009, Nucleic acids research.

[8]  E. Sage,et al.  The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells , 2009, Nucleic acids research.

[9]  L. Harrison,et al.  DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining , 2008, Nucleic acids research.

[10]  M. Hada,et al.  Formation of clustered DNA damage after high-LET irradiation: a review. , 2008, Journal of radiation research.

[11]  L. Symington,et al.  Break-induced replication: What is it and what is it for? , 2008, Cell cycle.

[12]  M. Lomax,et al.  An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli. , 2007, DNA repair.

[13]  M. Lomax,et al.  Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency , 2007, Nucleic acids research.

[14]  E. Sage,et al.  Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences , 2007, Nucleic acids research.

[15]  G. Dianov,et al.  Co-ordination of DNA single strand break repair. , 2007, DNA repair.

[16]  G. Dianov,et al.  DNA polymerase δ-dependent repair of DNA single strand breaks containing 3′-end proximal lesions , 2007, Nucleic acids research.

[17]  J. Thacker,et al.  The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage , 2006, Nucleic acids research.

[18]  L. Harrison,et al.  Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage. , 2006, DNA repair.

[19]  G. Dianov,et al.  Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks. , 2005, Journal of molecular biology.

[20]  G. Dianov,et al.  NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1 , 2005, Nucleic acids research.

[21]  E. Sage,et al.  Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins , 2005, Nucleic acids research.

[22]  M. Lomax,et al.  Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts. , 2004, Biochemistry.

[23]  Peter O'Neill,et al.  8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site. , 2004, DNA repair.

[24]  Peter O'Neill,et al.  Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site. , 2004, Nucleic acids research.

[25]  C. D. de Lara,et al.  Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. , 2002, Nucleic acids research.

[26]  G. Dianov,et al.  Repair of Clustered DNA Lesions , 2002, The Journal of Biological Chemistry.

[27]  Peter O'Neill,et al.  Efficiency of incision of an AP site within clustered DNA damage by the major human AP endonuclease. , 2002, Biochemistry.

[28]  P O'Neill,et al.  Computational Approach for Determining the Spectrum of DNA Damage Induced by Ionizing Radiation , 2001, Radiation research.

[29]  S. Wallace,et al.  Base excision repair processing of radiation-induced clustered DNA lesions. , 2001, Radiation protection dosimetry.

[30]  P O'Neill,et al.  Clustered DNA Damage, Influence on Damage Excision by XRS5 Nuclear Extracts and Escherichia coli Nth and Fpg Proteins* , 2000, The Journal of Biological Chemistry.

[31]  B M Sutherland,et al.  Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[32]  D. T. Goodhead,et al.  Quantitative modelling of DNA damage using Monte Carlo track structure method , 1999, Radiation and environmental biophysics.

[33]  M. Weinfeld,et al.  Reactivity of Human Apurinic/Apyrimidinic Endonuclease andEscherichia coli Exonuclease III with Bistranded Abasic Sites in DNA* , 1997, The Journal of Biological Chemistry.

[34]  P O'Neill,et al.  Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events. , 1997, International journal of radiation biology.

[35]  J. Gerlt,et al.  3'- and 5'-strand cleavage reactions catalyzed by the Fpg protein from Escherichia coli occur via successive beta- and delta-elimination mechanisms, respectively. , 1996, Biochemistry.

[36]  J. Ward,et al.  The complexity of DNA damage: relevance to biological consequences. , 1994, International journal of radiation biology.

[37]  M L Michaels,et al.  The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) , 1992, Journal of bacteriology.

[38]  S. Wallace,et al.  Processing of model single-strand breaks in phi X-174 RF transfecting DNA by Escherichia coli. , 1991, Radiation research.

[39]  T. O'Connor,et al.  Mechanism of DNA strand nicking at apurinic/apyrimidinic sites by Escherichia coli [formamidopyrimidine]DNA glycosylase. , 1989, The Biochemical journal.

[40]  J. Miller,et al.  A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. Noguchi,et al.  The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation. , 2009, Journal of radiation research.

[42]  R. Shi,et al.  Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli. , 2004, Nucleic acids research.

[43]  Y. Kow,et al.  Mechanism of action of Escherichia coli formamidopyrimidine N-glycosylase: role of K155 in substrate binding and product release. , 2001, Progress in nucleic acid research and molecular biology.

[44]  S. Wallace,et al.  In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites. , 1999, Journal of molecular biology.

[45]  D T Goodhead,et al.  Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. , 1994, International journal of radiation biology.

[46]  Jeffrey H. Miller,et al.  A short course in bacterial genetics , 1992 .

[47]  J. Ward,et al.  DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. , 1988, Progress in nucleic acid research and molecular biology.