Comments on nitric oxide in children with asthma, low- dose oral immunotherapy for cow's milk allergy, and SARS- Cov- 2 testing in school children

on Papadopoulos and food Both teams extensive literature search of recent studies highlighting new and their in the clinical for your continuous suggest citing when the introductory of your as they extensively sum marize current knowledge. The first selected research article in this issue reports on the STOPPA trial, a study aiming at characterizing nitric oxide production in asthmatic children in relation to environmental and genetic factors. 3 The authors led by Anna Hedman used an original approach by recruiting a large sample of monozygotic and dizygotic twin pairs, looking into blood test results such as eosinophils and IgE levels in relation to genetic factors. They found that more than half of the total covariance between nitric oxide levels and asthma was due to genetically driven effects of the specific IgE levels, but not the blood eosinophils. They conclude by highlighting the clinical heterogeneity of exhaled nitric oxide levels in relation to specific IgE levels in asthmatic children. Asthma is a major focus of PAI, and recent studies of interest to the readers have reported on the clinical fol low- up in children suffering from asthma. 4- 6 The influence of the environment, even when considering seemingly unrelated variables such as diet and air pollution, has been closely studied. 7 The articles commented on here shed new light into the interaction between well- known inflammatory and sensitization markers present in asthmatic children.