Betaine affects abdominal flare fat metabolism via regulating m6A RNA methylation in finishing pigs fed a low-energy diet

[1]  Zhangping Yang,et al.  Progress of m6A Methylation in Lipid Metabolism in Humans and Animals , 2022, Agriculture.

[2]  Wen-hong Deng,et al.  Key Molecules of Fatty Acid Metabolism in Gastric Cancer , 2022, Biomolecules.

[3]  X. Mao,et al.  All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling Pathway , 2022, Frontiers in Immunology.

[4]  Zhang Ruixia,et al.  Studies on the effects of hypothermia combined with hypoxia on rat skeletal muscle and lipid metabolism based on AMPK/PGC1α pathway , 2021, Journal of Orthopaedic Surgery and Research.

[5]  Huaxin Si,et al.  Mechanism of action and the uses betaine in pig production. , 2021, Journal of animal physiology and animal nutrition.

[6]  K. Kharbanda,et al.  Beneficial Effects of Betaine: A Comprehensive Review , 2021, Biology.

[7]  E. Demerath,et al.  Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health , 2021, Science Translational Medicine.

[8]  Y. Duan,et al.  Dietary supplementation with betaine or glycine improves the carcass trait, meat quality and lipid metabolism of finishing mini-pigs , 2021, Animal nutrition.

[9]  Cuiping Yang,et al.  The role of m6A modification in the biological functions and diseases , 2021, Signal Transduction and Targeted Therapy.

[10]  S. Corvera Cellular Heterogeneity in Adipose Tissues. , 2021, Annual review of physiology.

[11]  Chuan He,et al.  m6A RNA methylation: from mechanisms to therapeutic potential , 2021, The EMBO journal.

[12]  Tianhe Zhao,et al.  Fat mass and obesity‐associated protein regulates lipogenesis via m6A modification in fatty acid synthase mRNA , 2020, Cell biology international.

[13]  Dalong Zhu,et al.  Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction , 2020, Obesity Surgery.

[14]  Jiayao Yu,et al.  Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation , 2020, Frontiers in Pharmacology.

[15]  Liwei Xie,et al.  METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice , 2020, Nature Communications.

[16]  Min Tian,et al.  Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets , 2020, Nutrition & Metabolism.

[17]  Katya Frazier,et al.  Emerging role of m6A RNA methylation in nutritional physiology and metabolism , 2020, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[18]  R. Zhao,et al.  Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation , 2019, European Journal of Nutrition.

[19]  Zhiyong Zhang,et al.  METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes , 2019, Autophagy.

[20]  Chuan He,et al.  Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. , 2018, Cell reports.

[21]  Charlotte L. Scott,et al.  Macrophages and lipid metabolism , 2018, Cellular immunology.

[22]  R. Zhao,et al.  Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats. , 2018, The Journal of nutritional biochemistry.

[23]  Yizhen Wang,et al.  Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig , 2017, Journal of Animal Science and Biotechnology.

[24]  Yibin Kang,et al.  Lipid Metabolism Fuels Cancer's Spread. , 2017, Cell metabolism.

[25]  M. Laranjo,et al.  Long term betaine supplementation regulates genes involved in lipid and cholesterol metabolism of two muscles from an obese pig breed. , 2017, Meat science.

[26]  J. B. Kim,et al.  Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders , 2016, Front. Endocrinol..

[27]  Xihong Zhou,et al.  The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit. , 2015, The Journal of nutritional biochemistry.

[28]  V. Patel,et al.  Betaine, in context. , 2015 .

[29]  Arne Klungland,et al.  A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation , 2015, Genes & development.

[30]  Yizhen Wang,et al.  mRNA m⁶A methylation downregulates adipogenesis in porcine adipocytes. , 2015, Biochemical and biophysical research communications.

[31]  M. Brosnan,et al.  Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism , 2015, Amino Acids.

[32]  H. Ding,et al.  SREBP-1c overexpression induces triglycerides accumulation through increasing lipid synthesis and decreasing lipid oxidation and VLDL assembly in bovine hepatocytes , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[33]  Gideon Rechavi,et al.  Gene expression regulation mediated through reversible m6A RNA methylation , 2014, Nature Reviews Genetics.

[34]  R. Obeid,et al.  The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway , 2013, Nutrients.

[35]  H. Steinbrenner,et al.  Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs. , 2012, Journal of inorganic biochemistry.

[36]  P. Sellier,et al.  A review of the factors influencing the development of intermuscular adipose tissue in the growing pig. , 2011, Meat science.

[37]  Mengwei Zang,et al.  AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.

[38]  F. Foufelle,et al.  Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c , 2010, Diabetes, obesity & metabolism.

[39]  E. Esteve-Garcia,et al.  Tissue fatty acid composition of pigs fed different fat sources. , 2008, Animal : an international journal of animal bioscience.

[40]  Zi-rong Xu,et al.  Effect of dietary betaine supplementation on lipogenic enzyme activities and fatty acid synthase mRNA expression in finishing pigs , 2008 .

[41]  J. Aguilera,et al.  Synergistic effects of betaine and conjugated linoleic acid on the growth and carcass composition of growing Iberian pigs. , 2007, Journal of animal science.

[42]  A. Schinckel,et al.  Factors Affecting Fat Distribution in Pork Carcasses1 , 2007 .

[43]  E. Wagner,et al.  Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase , 2006, Science.

[44]  J. Huneau,et al.  A high-protein, high-fat, carbohydrate-free diet reduces energy intake, hepatic lipogenesis, and adiposity in rats. , 2006, The Journal of nutrition.

[45]  F. Dunshea,et al.  Interrelationships between porcine somatotropin (pST), betaine, and energy level on body composition and tissue distribution of finisher boars , 2004 .

[46]  C. Holm Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. , 2003, Biochemical Society transactions.

[47]  Roberto Conti,et al.  Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production , 2003, Nature Medicine.

[48]  N. Steele,et al.  Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed-restricted pig. , 2002, Journal of animal science.

[49]  M. Goran Energy metabolism and obesity. , 2000, The Medical clinics of North America.

[50]  R. G. Kauffman,et al.  Cellular and enzymatic changes in porcine adipose tissue during growth. , 1973, Journal of lipid research.

[51]  F. Dunshea,et al.  A review - fat deposition and metabolism in the pig. , 2003 .

[52]  A. Lewis,et al.  The Investigation of Betaine as a Growth Promotor and/or Carcass Modifier and the Efficacy of Betaine to Replace Methionine in Finishing Diets , 2000 .