Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment

[1]  C. Huard,et al.  Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension , 2019, American journal of respiratory and critical care medicine.

[2]  R. Gerszten,et al.  Human PAH is characterized by a pattern of lipid-related insulin resistance. , 2019, JCI insight.

[3]  M. Humbert,et al.  Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives , 2019, European Respiratory Journal.

[4]  M. Goumans,et al.  TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family , 2018, International journal of molecular sciences.

[5]  S. Chan,et al.  Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains , 2018, The Journal of clinical investigation.

[6]  J. Rabinowitz,et al.  Metabolomics and Isotope Tracing , 2018, Cell.

[7]  Q. Wells,et al.  A Metabolic Basis for Endothelial-to-Mesenchymal Transition. , 2018, Molecular cell.

[8]  P. Ježek,et al.  Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming , 2018, Antioxidants & redox signaling.

[9]  S. Archer Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension , 2017, Circulation.

[10]  P. Ježek,et al.  Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis , 2017, Circulation.

[11]  P. Carmeliet,et al.  Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2 , 2017, Circulation.

[12]  Richard B. Thompson,et al.  Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients , 2017, Science Translational Medicine.

[13]  Cholsoon Jang,et al.  Glutamine fuels proliferation but not migration of endothelial cells , 2017, The EMBO journal.

[14]  W. Janssen,et al.  TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension , 2017, Nature Communications.

[15]  P. Ježek,et al.  Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension. , 2017, Advances in experimental medicine and biology.

[16]  R. Hamanaka,et al.  Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production* , 2016, The Journal of Biological Chemistry.

[17]  A. Hevener,et al.  Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. , 2016, JCI insight.

[18]  A. D’Alessandro,et al.  Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. , 2016, Blood.

[19]  J. Loscalzo,et al.  Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. , 2016, The Journal of clinical investigation.

[20]  S. Gräf,et al.  Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension , 2015, Nature Medicine.

[21]  P. Carmeliet,et al.  Fatty acid carbon is essential for dNTP synthesis in endothelial cells , 2015, Nature.

[22]  S. Gupte,et al.  Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension. , 2015, American journal of physiology. Lung cellular and molecular physiology.

[23]  Peter Carmeliet,et al.  Metabolism of stromal and immune cells in health and disease , 2014, Nature.

[24]  E. Michelakis,et al.  The metabolic basis of pulmonary arterial hypertension. , 2014, Cell metabolism.

[25]  Tomer Shlomi,et al.  Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia , 2013, Molecular systems biology.

[26]  J. Chabon,et al.  Transforming Growth Factor-&bgr; Signaling Promotes Pulmonary Hypertension Caused by Schistosoma Mansoni , 2013, Circulation.

[27]  P. Carmeliet,et al.  Role of PFKFB3-Driven Glycolysis in Vessel Sprouting , 2013, Cell.

[28]  S. Pullamsetti,et al.  Heterogeneity in Lung 18FDG Uptake in Pulmonary Arterial Hypertension: Potential of Dynamic 18FDG Positron Emission Tomography With Kinetic Analysis as a Bridging Biomarker for Pulmonary Vascular Remodeling Targeted Treatments , 2013, Circulation.

[29]  R. Hamid,et al.  Pulmonary Circulation | April-june 2012 | Vol 2 | No 2 Research Ar Ticle Metabolomic Analysis of Bone Morphogenetic Protein Receptor Type 2 Mutations in Human Pulmonary Endothelium Reveals Widespread Metabolic Reprogramming Several Animal Models of Pah , 2022 .

[30]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[31]  G. Semenza,et al.  HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. , 2011, American journal of respiratory and critical care medicine.

[32]  G. Lopaschuk,et al.  Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension , 2010, Science Translational Medicine.

[33]  B. Krishnamachary,et al.  Cardiovascular , Pulmonary and Renal Pathology Hypoxia Inducible-Factor 1 Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells , 2010 .

[34]  W. Riley,et al.  Mathematical treatment of isotopologue and isotopomer speciation and fractionation in biochemical kinetics , 2009 .

[35]  Cerys Docx,et al.  Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. , 2009, The American journal of pathology.

[36]  Q. Lu Transforming growth factor- (cid:1) 1 protects against pulmonary artery endothelial cell apoptosis via ALK5 , 2022 .

[37]  P. Sehgal,et al.  Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension. , 2008, American journal of respiratory and critical care medicine.

[38]  W. Zwerschke,et al.  Premature senescence of human endothelial cells induced by inhibition of glutaminase , 2008, Biogerontology.

[39]  R. Lechleider,et al.  Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. , 2007, American journal of respiratory cell and molecular biology.

[40]  Raed A Dweik,et al.  Alterations of cellular bioenergetics in pulmonary artery endothelial cells , 2007, Proceedings of the National Academy of Sciences.

[41]  S. Oparil,et al.  ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells. , 2007, Journal of applied physiology.

[42]  S. Archer,et al.  An Abnormal Mitochondrial–Hypoxia Inducible Factor-1&agr;–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension , 2006, Circulation.

[43]  G. Collins The next generation. , 2006, Scientific American.

[44]  L. Olson,et al.  Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrier. , 2002, Investigative ophthalmology & visual science.