Jamu Informatics: A New Perspective in Jamu Research

The paradigm of drug development has been shifted from one-drug one-target into multi drug network target. TheIndonesian traditional medicines, Jamu,is composed fromseveral plants. It provides a promising source in developing drug addressing this new paradigm. In this paper, we propose a concept of Jamu informatics as a tool in understanding Jamu as well as guidance in developing a new Jamu formula. We provide our implementation of Jamu informatics started from modeling the ingredients of Jamu as to estimating the efficacy of Jamu. We found that the developed model performs well in predicting Jamu efficacy given the information of its ingredients. Given the model, a new Jamu formula targeted for type-2 diabetes is developed and tested to Zebrafish.The experiment results show that the new Jamu formula is promosing and showing better performance compared to negative control. The ingredient composition of the new Jamu formula is then optimized using the response surface optimization. Finally, we evaluate the working mechanism of the new formula using network pharmacology.

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