Regional venous drainage of the human heart.

Blood samples obtained from the coronary sinus in man contain venous blood draining from left ventricular myocardium. It is believed by many investigators that coronary sinus blood in man is composed almost entirely of left ventricular efflux. That this is true in the canine heart is firmly established (Rayford et al., 1959). This principle has been widely accepted in the many studies which have been carried out using highly diffusible indicators to measure coronary blood flow, in which it is presumed that left ventricular flow per unit muscle mass is being measured (Gorlin, 1960). The present study was designed to test the hypothesis that coronary sinus blood is composed primarily of left ventricular efflux. The methods employed are those of detailed analysis of the fine ramifications of the coronary venous system to determine in semiquantitative fashion the number of small vessels contributing to venous drainage from each segment of the myocardium.