Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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C. Pirker | W. Berger | W. Jäger | M. Grusch | P. Heffeter | S. van Schoonhoven | A. Terenzi | B. Englinger | G. Timelthaler | C. Kowol | Daniela Heilos | J. Senkiv | Patrick Moser | L. Gabler | S. Kallus | Lisa Gabler
[1] P. Sieger,et al. pH‐dependent solubility and permeability profiles: A useful tool for prediction of oral bioavailability , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[2] G. Robertson,et al. Effect of lysosomotropic molecules on cellular homeostasis , 2017, Pharmacological research.
[3] Manuel Hidalgo,et al. Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[4] M. Katoh. Therapeutics Targeting FGF Signaling Network in Human Diseases. , 2016, Trends in pharmacological sciences.
[5] R. Kaiser,et al. Pharmacokinetic Properties of Nintedanib in Healthy Volunteers and Patients With Advanced Cancer , 2016, Journal of clinical pharmacology.
[6] D. Richardson,et al. Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance. , 2016, Free radical biology & medicine.
[7] D. Lötsch,et al. Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression , 2016, Oncotarget.
[8] J. Schellens,et al. Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[9] M. Katoh. FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review) , 2016, International journal of molecular medicine.
[10] K. O'Byrne,et al. Targeting the fibroblast growth factor receptor family in cancer. , 2016, Cancer treatment reviews.
[11] R. Grose,et al. Dysregulated FGF signalling in neoplastic disorders. , 2016, Seminars in cell & developmental biology.
[12] Jian Xiao,et al. Fibroblast growth factors, old kids on the new block. , 2016, Seminars in cell & developmental biology.
[13] A. Russo,et al. Nintedanib in NSCLC: evidence to date and place in therapy , 2016, Therapeutic advances in medical oncology.
[14] M. Varella‐Garcia,et al. Fibroblast Growth Factor Receptors: From the Oncogenic Pathway to Targeted Therapy. , 2016, Current molecular medicine.
[15] Y. Assaraf,et al. Lysosomes as mediators of drug resistance in cancer. , 2016, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[16] G. Knott,et al. NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro. , 2015, Chemical communications.
[17] P. Lv,et al. Simultaneous determination of nintedanib and its metabolite BIBF 1202 in different tissues of mice by UPLC-MS/MS and its application in drug tissue distribution study. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[18] Razelle Kurzrock,et al. The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing , 2015, Clinical Cancer Research.
[19] S. Sleijfer,et al. Lysosomal Sequestration Determines Intracellular Imatinib Levels , 2015, Molecular Pharmacology.
[20] F. André,et al. Targeting FGFR Signaling in Cancer , 2015, Clinical Cancer Research.
[21] L. Raez,et al. Nintedanib in non-small cell lung cancer: from preclinical to approval , 2015, Therapeutic advances in respiratory disease.
[22] H. Verheul,et al. The Potential Role of Lysosomal Sequestration in Sunitinib Resistance of Renal Cell Cancer , 2015, Journal of kidney cancer and VHL.
[23] R. Kaiser,et al. Nintedanib: from discovery to the clinic. , 2015, Journal of medicinal chemistry.
[24] Y. Assaraf,et al. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance , 2014, Oncotarget.
[25] Dan Fu,et al. Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering , 2014, Nature chemistry.
[26] F. Hirsch,et al. FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies , 2014, Clinical Cancer Research.
[27] H. Nakagama,et al. FGF Receptors: Cancer Biology and Therapeutics , 2014, Medicinal research reviews.
[28] W. Berger,et al. Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis. , 2012, Cancer research.
[29] Andrew P Thomas,et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. , 2012, Cancer research.
[30] A. Ballabio,et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB , 2012, The EMBO journal.
[31] W. Berger,et al. Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy , 2011, Expert opinion on therapeutic targets.
[32] Yvonne Will,et al. A high content screening assay for identifying lysosomotropic compounds. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.
[33] Kenneth W Dunn,et al. A practical guide to evaluating colocalization in biological microscopy. , 2011, American journal of physiology. Cell physiology.
[34] F. Ahmad,et al. The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review , 2011, Expert opinion on therapeutic patents.
[35] A. Balmain,et al. Guidelines for the welfare and use of animals in cancer research , 2010, British Journal of Cancer.
[36] N. Turner,et al. Fibroblast growth factor signalling: from development to cancer , 2010, Nature Reviews Cancer.
[37] Johannes Kornhuber,et al. Quantitative modeling of selective lysosomal targeting for drug design , 2008, European Biophysics Journal.
[38] Sylvain V Costes,et al. Automatic and quantitative measurement of protein-protein colocalization in live cells. , 2004, Biophysical journal.
[39] A. Wiedlocha,et al. Signaling, internalization, and intracellular activity of fibroblast growth factor. , 2004, Current topics in microbiology and immunology.
[40] W. Langdon,et al. Cbl: many adaptations to regulate protein tyrosine kinases , 2001, Nature Reviews Molecular Cell Biology.
[41] Y. Moriyama,et al. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. , 1991, The Journal of biological chemistry.
[42] T. Chou,et al. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. , 1984, Advances in enzyme regulation.
[43] P. Tulkens,et al. Commentary. Lysosomotropic agents. , 1974, Biochemical pharmacology.