Vacata‐ and divacataporphyrin: New photosensitizers for application in photodynamic therapy—an in vitro study

The photodynamic therapy is a well‐known method of treatment of both malignant tumors and non‐tumor lesions in human patients. In the present study, we aimed at evaluating the in vitro efficacy of the new photosensitizing agents, vacataporphyrin (VP), and divacataporphyrin (DVP).

[1]  L. Szterenberg,et al.  A flexible porphyrin-annulene hybrid: a nonporphyrin conformation for meso-tetraaryldivacataporphyrin. , 2011, Chemistry.

[2]  I. Kwon,et al.  Heavy-atomic construction of photosensitizer nanoparticles for enhanced photodynamic therapy of cancer. , 2011, Small.

[3]  A. Morita,et al.  Effect and Mechanism of a New Photodynamic Therapy with Glycoconjugated Fullerene , 2010, Photochemistry and photobiology.

[4]  P. Hillemanns,et al.  Effects of photodynamic therapy using topical applied hexylaminolevulinate and methylaminolevulinate upon the integrity of cervical epithelium , 2010, Lasers in surgery and medicine.

[5]  Michael S Patterson,et al.  A dynamic model for ALA-PDT of skin: simulation of temporal and spatial distributions of ground-state oxygen, photosensitizer and singlet oxygen , 2010, Physics in medicine and biology.

[6]  Sérgio Simões,et al.  New Halogenated Water‐Soluble Chlorin and Bacteriochlorin as Photostable PDT Sensitizers: Synthesis, Spectroscopy, Photophysics, and in vitro Photosensitizing Efficacy , 2010, ChemMedChem.

[7]  Zhilong Chen,et al.  Studies on preparation and photodynamic mechanism of chlorin P6-13,15-N-(cyclohexyl)cycloimide (Chlorin-H) and its antitumor effect for photodynamic therapy in vitro and in vivo. , 2010, Bioorganic & medicinal chemistry.

[8]  Y. Chuang,et al.  GreenLight HPS laser 120‐W versus diode laser 200‐W vaporization of the prostate: Comparative clinical experience , 2010, Lasers in surgery and medicine.

[9]  K. Moraes,et al.  Cellular changes after photodynamic therapy on HEp-2 cells using the new ZnPcBr(8) phthalocyanine. , 2010, Photomedicine and laser surgery.

[10]  K. Umezawa,et al.  Target‐selective degradation of cancer‐related proteins by novel photosensitizers for molecular‐targeted photodynamic therapy , 2009, Cancer science.

[11]  H Abrahamse,et al.  Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. , 2009, Journal of photochemistry and photobiology. B, Biology.

[12]  D. Kessel,et al.  Apoptotic and autophagic responses to Bcl-2 inhibition and photodamage , 2007, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[13]  Hector Nava,et al.  Clinical Pharmacokinetics of the PDT Photosensitizers Porfimer Sodium (Photofrin), 2‐[1‐Hexyloxyethyl]‐2‐Devinyl Pyropheophorbide‐a (Photochlor) and 5‐ALA‐Induced Protoporphyrin IX , 2006, Lasers in surgery and medicine.

[14]  Miłosz Pawlicki,et al.  Cadmium(II), nickel(II), and zinc(II) complexes of vacataporphyrin: a variable annulene conformation inside a standard porphyrin frame. , 2005, Inorganic chemistry.

[15]  G. Oremek,et al.  Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture. , 2004, Journal of experimental therapeutics & oncology.

[16]  Z. Ciunik,et al.  A direct link between annulene and porphyrin chemistry--21-vacataporphyrin. , 2002, Chemistry.

[17]  A. Taneja Treatment of vitiligo. , 2002, The Journal of dermatological treatment.

[18]  E. Jeffes Levulan ® : the first approved topical photosensitizer for the treatment of actinic keratosis , 2002, The Journal of dermatological treatment.

[19]  R. Rotomskis,et al.  New potent sensitizers for photodynamic therapy: 21-oxaporphyrin, 21-thiaporphyrin and 21,23-dithiaporphyrin induce extensive tumor necrosis , 1999, Journal of Cancer Research and Clinical Oncology.

[20]  C. Gomer,et al.  Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function. , 1999, Cancer research.

[21]  E. Marcinkowska,et al.  The new sensitizing agents for photodynamic therapy: 21-selenaporphyrin and 21-thiaporphyrin. , 1997, Anticancer Research.

[22]  P. Calzavara-Pinton,et al.  Repetitive photodynamic therapy with topical delta-aminolaevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. , 1995, Journal of photochemistry and photobiology. B, Biology.

[23]  G. Wagnières,et al.  Clinical pharmacokinetic studies of photofrin by fluorescence spectroscopy in the oral cavity, the esophagus, and the bronchi , 1995, Cancer.

[24]  R. Bonnett,et al.  Porphyrin sensitizers in tumour phototherapy. Novel sensitizers of the chlorin and bacteriochlorin class with amphiphilic properties. , 1990, Journal of photochemistry and photobiology. B, Biology.

[25]  C J Gomer,et al.  Differential cell photosensitivity following porphyrin photodynamic therapy. , 1988, Cancer research.

[26]  E. Ben-hur,et al.  Mechanism of uptake of sulfonated metallophthalocyanines by cultured mammalian cells. , 1987, Cancer letters.

[27]  M. Olivo,et al.  Apoptosis induced by photosensitizers (Perylquinone derivatives) in human carcinoma cells: a possible relevance to photodynamic therapy. , 2002, Asian Journal of Surgery.

[28]  N. Crompton,et al.  In vitro effects and localisation of the photosensitizers m‐THPC and m‐THPC MD on carcinoma cells of the human breast (MCF‐7) and chinese hamster fibroblasts (V‐79) , 1997, Lasers in surgery and medicine.

[29]  A. Leunig,et al.  An in vitro model to study cellular photosensitizer uptake and photodynamic dose-response relationships of tumor cells , 1993, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.