Absorption of lignocaine and bupivacaine from the respiratory tract during fibreoptic bronchoscopy.

Absorption of lignocaine and bupivacaine from the upper and lower respiratory tract was studied in patients undergoing fibreoptic bronchoscopy. No significant differences were found between the drugs and between the routes of administration in terms of the time taken to achieve maximum plasma concentrations. The relative availability of lignocaine was greater following administration via the upper respiratory tract, but bupivacaine availability did not differ. The apparent clearance of lignocaine was not affected by the route of administration but bupivacaine clearance was higher following administration via the lower respiratory tract. Bupivacaine, previously unreported as a topical agent in man, produced adequate anaesthesia at one-eighth of the dose of lignocaine. Plasma bupivacaine concentrations had a very wide safety margin.

[1]  D. Jones,et al.  Plasma concentrations of lignocaine and its metabolites during fibreoptic bronchoscopy. , 1982, British journal of anaesthesia.

[2]  E. Camporesi,et al.  Topical anesthesia of tracheal receptors. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[3]  G. Tucker,et al.  Clinical Pharmacokinetics of Local Anaesthetics , 1979, Clinical pharmacokinetics.

[4]  B. Mcanalley,et al.  Effect of lung edema on the pulmonary absorption of drugs. , 1978, Life sciences.

[5]  L S Schanker,et al.  Drug absorption from the lung. , 1978, Biochemical pharmacology.

[6]  R. Nation,et al.  Lignocaine kinetics in cardiac patients and aged subjects. , 1977, British journal of clinical pharmacology.

[7]  G. Drummond,et al.  Plasma lignocaine concentrations following endotracheal spraying with an aerosol. , 1977, British journal of anaesthesia.

[8]  G. Drummond,et al.  PLASMA LIGNOCAINE CONCENTRATIONS FOLLOWING ENDOTRACHEAL SPRAYING WITH AN AEROSOL , 1976 .

[9]  J. Curran,et al.  Topical analgesia before tracheal intubation , 1975, Anaesthesia.

[10]  S. Åkerman.  Surface anaesthetic properties of the new local anaesthetic amid etidocaine (Duranest): A laboratory evaluation. , 1975, British journal of anaesthesia.

[11]  G. Tucker,et al.  Meperidine and other basic drugs: general method for their determination in plasma. , 1974, Journal of pharmaceutical sciences.

[12]  L. Telivuo.  An Experimental Study on the Absorption of Some Local Anaesthetics Through the Lower Respiratory Tract , 1965, Acta anaesthesiologica Scandinavica. Supplementum.