Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes.

[1]  A. Roddick,et al.  Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis , 2019, JAMA.

[2]  J. Gustafsson,et al.  Colitis‐induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity , 2019, International journal of cancer.

[3]  Nayoung Kim,et al.  Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development , 2018, Cancer research and treatment : official journal of Korean Cancer Association.

[4]  E. Weiderpass,et al.  Menopausal hormone therapy and colorectal cancer: a linkage between nationwide registries in Norway , 2017, BMJ Open.

[5]  H. Adami,et al.  Menopausal hormone therapy and cancer risk: An overestimated risk? , 2017, European journal of cancer.

[6]  C. Lindskog,et al.  A pathology atlas of the human cancer transcriptome , 2017, Science.

[7]  Carl-Magnus Clausson,et al.  Insufficient antibody validation challenges oestrogen receptor beta research , 2017, Nature Communications.

[8]  R. Lobo.  Hormone-replacement therapy: current thinking , 2017, Nature Reviews Endocrinology.

[9]  Liu Li,et al.  IL-1β/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis. , 2016, Archives of biochemistry and biophysics.

[10]  J. Gustafsson,et al.  Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205 - PROX1 mechanism , 2016, Oncotarget.

[11]  R. Langley,et al.  Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone? , 2016, Current Colorectal Cancer Reports.

[12]  J. Potter,et al.  A Prospective Evaluation of Endogenous Sex Hormone Levels and Colorectal Cancer Risk in Postmenopausal Women. , 2015, Journal of the National Cancer Institute.

[13]  G. von Heijne,et al.  Tissue-based map of the human proteome , 2015, Science.

[14]  F. Pontén,et al.  Estrogen receptor β expression induces changes in the microRNA pool in human colon cancer cells. , 2013, Carcinogenesis.

[15]  Y. Kakeji,et al.  Estrogen receptor‐β gene polymorphism and colorectal cancer risk: Effect modified by body mass index and isoflavone intake , 2013, International journal of cancer.

[16]  J. Potter,et al.  Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women. , 2013, Cancer research.

[17]  M. Bissonnette,et al.  Estrogen receptor‐β protects against colitis‐associated neoplasia in mice , 2012, International journal of cancer.

[18]  Dudley Lamming,et al.  mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake , 2012, Nature.

[19]  Andrew C. Li,et al.  An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation , 2011, Cell.

[20]  J. Carrier,et al.  Chemopreventive effect of ERβ‐Selective agonist on intestinal tumorigenesis in ApcMin/+ Mice , 2011, Molecular carcinogenesis.

[21]  K. Korach,et al.  Enhanced Induction of Mucin-Depleted Foci in Estrogen Receptor β Knockout Mice , 2010, Cancer Prevention Research.

[22]  Olle Broström,et al.  Inflammatory bowel disease confers a lower risk of colorectal cancer to females than to males. , 2010, Gastroenterology.

[23]  Michael Karin,et al.  Inflammation and colon cancer. , 2010, Gastroenterology.

[24]  C. Allred,et al.  Estradiol alters cell growth in nonmalignant colonocytes and reduces the formation of preneoplastic lesions in the colon. , 2009, Cancer research.

[25]  H. Cross,et al.  Mutual associations between malignancy, age, gender, and subsite incidence of colorectal cancer. , 2009, Anticancer research.

[26]  J. Hartman,et al.  Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. , 2009, Cancer research.

[27]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[28]  R. Handa,et al.  A Role for the Androgen Metabolite, 5α‐Androstane‐3β,17β‐Diol, in Modulating Oestrogen Receptor β‐Mediated Regulation of Hormonal Stress Reactivity , 2009, Journal of neuroendocrinology.

[29]  J. Carrier,et al.  Estrogen receptor β deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice , 2008, International journal of cancer.

[30]  J. Potter,et al.  Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women. , 2007, Cancer research.

[31]  S. Hamilton,et al.  Oral contraceptives and polyp regression in familial adenomatous polyposis. , 2005, Gastroenterology.

[32]  L. Coussens,et al.  Inflammation and cancer , 2002, Nature.

[33]  E. Negri,et al.  Oral contraceptives and colorectal cancer risk: a meta-analysis , 2001, British Journal of Cancer.

[34]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[35]  F. Grodstein,et al.  Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. , 1999, The American journal of medicine.

[36]  M. Karin,et al.  The IKK/NF-kappa B pathway. , 2002 .