An APD-based Iterative Reconstruction Method for Simultaneous Technetium-99m/lodine-123 SPECT Imaging

In this paper, we present an iterative reconstruction method for Dual-Isotope SPECT (DI-SPECT) imaging. The method includes accurately analytically computed cross-talk and scatter corrections provided by the APD (Analytical Photon Distribution) algorithm. Simulation and experimental results demonstrate significant improvement in image quality over uncorrected images.