Updated Results of the COVID-19 in MS Global Data Sharing Initiative Anti-CD20 and Other Risk Factors Associated With COVID-19 Severity

Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), associated with higher probabilities of hospitalization (4% [95% CI 1 – 7] and 7% [95% CI 4 – 11]), ICU/arti fi cial ventilation (2% [95% CI 0 – 4] and 4% [95% CI 2 – 6]), and death (1% [95% CI 0 – 2] and 2% [95% CI 1 – 4]) (predicted marginal e ff ects). Untreated patients had 5% (95% CI 2 – 8), 3% (95% CI 1 – 5), and 1% (95% CI 0 – 3) higher probabilities of the 3 respective levels of COVID-19 severity than glatiramer acetate. Compared with pooled other DMTs and with natalizumab, the associations of ocrelizumab also