Real, rubber or virtual: The vision of “one’s own” body as a means for pain modulation. A narrative review

In the last few years a branch of pain research has been focussing on the modulatory effects of the vision of the body on pain perception. So, for instance, the vision of one's own real body has been proven to induce analgesic effects. On the other hand, bodily illusions such as the rubber hand illusion have provided new tools for the study of perceptual processes during altered body ownership states. Recently, new paradigms of body ownership made use of a technology that is going places both in clinical and in experimental settings, i.e. virtual reality. While the vision of one's own real body has been proven to yield compelling analgesic effects, slightly more controversial are those attributed to the vision of "owned" dummy bodies. This review will discuss the studies that examined the effects on pain perception of the vision of the own body, with or without body ownership illusions.

[1]  G. Moseley,et al.  Evidence for distorted mental representation of the hand in osteoarthritis , 2014, Rheumatology.

[2]  R. Newport,et al.  Analgesic effects of multisensory illusions in osteoarthritis , 2011, Rheumatology.

[3]  Maria V. Sanchez-Vives,et al.  Extending Body Space in Immersive Virtual Reality: A Very Long Arm Illusion , 2012, PloS one.

[4]  M. Slater,et al.  The building blocks of the full body ownership illusion , 2013, Front. Hum. Neurosci..

[5]  Marjolein P. M. Kammers,et al.  Self awareness and the body image. , 2009, Acta psychologica.

[6]  D. Lloyd,et al.  Embodied experience: A first-person investigation of the rubber hand illusion , 2010 .

[7]  A. Geva,et al.  Touch feel illusion in schizophrenic patients , 2000, Biological Psychiatry.

[8]  H. Flor,et al.  Site-specific visual feedback reduces pain perception , 2013, PAIN®.

[9]  J. Kállai,et al.  The rubber hand illusion increases heat pain threshold , 2014, European journal of pain.

[10]  H. Hoffman,et al.  Use of virtual reality for adjunctive treatment of adult burn pain during physical therapy: a controlled study. , 2000, The Clinical journal of pain.

[11]  Jonathan D. Cohen,et al.  Rubber hands ‘feel’ touch that eyes see , 1998, Nature.

[12]  Valeria I. Petkova,et al.  The Perspective Matters! Multisensory Integration in Ego-Centric Reference Frames Determines Full-Body Ownership , 2011, Front. Psychology.

[13]  Danielle C. Turner,et al.  Exploring the Impact of Ketamine on the Experience of Illusory Body Ownership , 2011, Biological Psychiatry.

[14]  Eric J Seibel,et al.  Virtual reality helmet display quality influences the magnitude of virtual reality analgesia. , 2006, The journal of pain : official journal of the American Pain Society.

[15]  M. Peters Emotional and Cognitive Influences on Pain Experience. , 2015, Modern trends in pharmacopsychiatry.

[16]  U. Proske,et al.  Sensing the body in chronic pain: A review of psychophysical studies implicating altered body representation , 2015, Neuroscience & Biobehavioral Reviews.

[17]  Maria V. Sanchez-Vives,et al.  Inducing Illusory Ownership of a Virtual Body , 2009, Front. Neurosci..

[18]  Jimmie Leppink,et al.  On causality and mechanisms in medical education research: an example of path analysis , 2015, Perspectives on Medical Education.

[19]  P. Haggard,et al.  Visually Induced Analgesia: Seeing the Body Reduces Pain , 2009, The Journal of Neuroscience.

[20]  Mel Slater,et al.  First-Person Perspective Virtual Body Posture Influences Stress: A Virtual Reality Body Ownership Study , 2016, PloS one.

[21]  S. Tipper,et al.  Vision influences tactile perception without proprioceptive orienting , 1998, Neuroreport.

[22]  Maria V. Sanchez-Vives,et al.  Modulation of pain threshold by virtual body ownership , 2014, European journal of pain.

[23]  Hunter G Hoffman,et al.  The Analgesic Effects of Opioids and Immersive Virtual Reality Distraction: Evidence from Subjective and Functional Brain Imaging Assessments , 2007, Anesthesia and analgesia.

[24]  V. Ramachandran,et al.  Size reduction using Mirror Visual Feedback (MVF) reduces phantom pain , 2009, Neurocase.

[25]  M. Bushnell,et al.  Pain imaging in health and disease--how far have we come? , 2010, The Journal of clinical investigation.

[26]  Valeria I. Petkova,et al.  No Pain Relief with the Rubber Hand Illusion , 2012, PloS one.

[27]  Marjolein P. M. Kammers,et al.  Visual Distortion of Body Size Modulates Pain Perception , 2011, Psychological science.

[28]  Claus Lamm,et al.  The Neural Substrate of Human Empathy: Effects of Perspective-taking and Cognitive Appraisal , 2007, Journal of Cognitive Neuroscience.

[29]  Eric J. Seibel,et al.  Virtual Reality as an Adjunctive Non-pharmacologic Analgesic for Acute Burn Pain During Medical Procedures , 2011, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[30]  P. Haggard,et al.  Vision of the body modulates somatosensory intracortical inhibition. , 2011, Cerebral cortex.

[31]  H. Hoffman,et al.  Virtual Reality Pain Control During Burn Wound Debridement in the Hydrotank , 2008, The Clinical journal of pain.

[32]  V. Ramachandran,et al.  Synaesthesia in phantom limbs induced with mirrors , 1996, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[33]  P. Haggard,et al.  Changes in cortical oscillations linked to multisensory modulation of nociception , 2013, The European journal of neuroscience.

[34]  M. Tarr,et al.  Virtual reality in behavioral neuroscience and beyond , 2002, Nature Neuroscience.

[35]  Andreas K. Engel,et al.  Crossmodal shaping of pain: a multisensory approach to nociception , 2014, Trends in Cognitive Sciences.

[36]  Eric J. Seibel,et al.  Feasibility of Articulated Arm Mounted Oculus Rift Virtual Reality Goggles for Adjunctive Pain Control During Occupational Therapy in Pediatric Burn Patients , 2014, Cyberpsychology Behav. Soc. Netw..

[37]  H. Ehrsson The Experimental Induction of Out-of-Body Experiences , 2007, Science.

[38]  Christian Frings,et al.  Vision affects tactile target and distractor processing even when space is task-irrelevant , 2014, Front. Psychol..

[39]  E. Valentini,et al.  Cognitive aspects of nociception and pain. Bridging neurophysiology with cognitive psychology , 2012, Neurophysiologie Clinique/Clinical Neurophysiology.

[40]  Tabitha C. Peck,et al.  Putting yourself in the skin of a black avatar reduces implicit racial bias , 2013, Consciousness and Cognition.

[41]  P. Haggard,et al.  Spatial Sensory Organization and Body Representation in Pain Perception , 2013, Current Biology.

[42]  Olaf Blanke,et al.  Seeing and identifying with a virtual body decreases pain perception. , 2011, European journal of pain.

[43]  Hunter G Hoffman,et al.  Virtual reality pain control during burn wound debridement of combat-related burn injuries using robot-like arm mounted VR goggles. , 2011, The Journal of trauma.

[44]  Maria V. Sanchez-Vives,et al.  First Person Experience of Body Transfer in Virtual Reality , 2010, PloS one.

[45]  Christopher L. Greer,et al.  Side effects of commonly prescribed analgesic medications. , 2014, Physical medicine and rehabilitation clinics of North America.

[46]  A. Druin,et al.  Virtual environments and interactivity: windows to the future , 1989, SIGGRAPH 1989.

[47]  Maria V. Sanchez-Vives,et al.  From presence to consciousness through virtual reality , 2005, Nature Reviews Neuroscience.

[48]  Eduardo García España Terminology , 1973, Hybrid Nuclear Energy Systems.

[49]  Tabitha C. Peck,et al.  A threat to a virtual hand elicits motor cortex activation , 2014, Experimental Brain Research.

[50]  Viviana Betti,et al.  Seeing the pain of others while being in pain: A laser-evoked potentials study , 2008, NeuroImage.

[51]  Ryota Imai,et al.  Factors associated with the modulation of pain by visual distortion of body size , 2014, Front. Hum. Neurosci..

[52]  Author's reply to the commentary by Gilpin et al , 2015, European journal of pain.

[53]  H. Henrik Ehrsson,et al.  Disowning one’s seen real body during an out-of-body illusion , 2012, Consciousness and Cognition.

[54]  M. Slater,et al.  Decreased Corticospinal Excitability after the Illusion of Missing Part of the Arm , 2016, Front. Hum. Neurosci..

[55]  Hunter G. Hoffman,et al.  Modulation of thermal pain-related brain activity with virtual reality: evidence from fMRI , 2004, Neuroreport.

[56]  A. Löffler,et al.  Watching your pain site reduces pain intensity in chronic back pain patients , 2016, European journal of pain.

[57]  A. Vania Apkarian,et al.  Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain , 2011, PAIN.

[58]  H. Coslett,et al.  From maps to form to space: Touch and the body schema , 2010, Neuropsychologia.

[59]  M. Lindquist,et al.  An fMRI-based neurologic signature of physical pain. , 2013, The New England journal of medicine.

[60]  K. Davis,et al.  A neurocognitive model of attention to pain: Behavioral and neuroimaging evidence , 2009, PAIN®.

[61]  C. Spence,et al.  Visual distortion of a limb modulates the pain and swelling evoked by movement , 2008, Current Biology.

[62]  Joan Llobera,et al.  Size and Viewpoint of an Embodied Virtual Body Affect the Processing of Painful Stimuli. , 2016, The journal of pain : official journal of the American Pain Society.

[63]  Maria V. Sanchez-Vives,et al.  Towards a Digital Body: The Virtual Arm Illusion , 2008, Frontiers in human neuroscience.

[64]  Mark Tommerdahl,et al.  Role of primary somatosensory cortex in the coding of pain , 2013, PAIN®.

[65]  T. Metzinger,et al.  Video Ergo Sum: Manipulating Bodily Self-Consciousness , 2007, Science.

[66]  Á. Mayer,et al.  Body schema and body awareness of amputees , 2008, Prosthetics and orthotics international.

[67]  A. Mouraux,et al.  Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity. , 2009, Journal of neurophysiology.

[68]  Gian Domenico Iannetti,et al.  A multisensory investigation of the functional significance of the “pain matrix” , 2011, NeuroImage.

[69]  L. Milling,et al.  The effectiveness of virtual reality distraction for pain reduction: a systematic review. , 2010, Clinical psychology review.

[70]  Martin Lotze,et al.  Role of distorted body image in pain , 2007, Current rheumatology reports.

[71]  Maria V. Sanchez-Vives,et al.  Virtual Hand Illusion Induced by Visuomotor Correlations , 2010, PloS one.

[72]  K. Davis,et al.  Theories of pain: from specificity to gate control. , 2013, Journal of neurophysiology.

[73]  Justin M. Harris,et al.  If I Were You: Perceptual Illusion of Body Swapping , 2008, PloS one.

[74]  P. Haggard,et al.  Touch and the body , 2010, Neuroscience & Biobehavioral Reviews.

[75]  M. Slater,et al.  Illusory ownership of a virtual child body causes overestimation of object sizes and implicit attitude changes , 2013, Proceedings of the National Academy of Sciences.

[76]  T. Furness,et al.  Virtual reality as an adjunctive pain control during burn wound care in adolescent patients , 2000, Pain.

[77]  R. Melzack Pain and the neuromatrix in the brain. , 2001, Journal of dental education.

[78]  Giuseppe Riva,et al.  Psychological Factors Influencing the Effectiveness of Virtual Reality-Based Analgesia: A Systematic Review , 2014, Cyberpsychology Behav. Soc. Netw..

[79]  Allison Druin,et al.  Virtual environments and interactivity: windows to the future , 1989, SIGGRAPH '89.

[80]  Riitta Hari,et al.  The compassionate brain: humans detect intensity of pain from another's face. , 2006, Cerebral cortex.

[81]  Konrad Paul Kording,et al.  Over my fake body: body ownership illusions for studying the multisensory basis of own-body perception , 2015, Front. Hum. Neurosci..

[82]  A. Artaud The Theater and Its Double , 1958 .

[83]  S. Gibson,et al.  Feeling the burn: When it looks like it hurts, and belongs to me, it really does hurt more , 2015, Consciousness and Cognition.

[84]  W. Hall,et al.  Prevalence and Correlates of Suicidal Thoughts and Suicide Attempts in People Prescribed Pharmaceutical Opioids for Chronic Pain , 2016, The Clinical journal of pain.

[85]  Marta Siedlecka,et al.  Rubber Hand Illusion Reduces Discomfort Caused by Cold Stimulus , 2014, PloS one.

[86]  E. Macaluso,et al.  The representation of space near the body through touch and vision , 2010, Neuropsychologia.

[87]  Maria V. Sanchez-Vives,et al.  What Color is My Arm? Changes in Skin Color of an Embodied Virtual Arm Modulates Pain Threshold , 2013, Front. Hum. Neurosci..

[88]  P. Haggard,et al.  Linking Pain and the Body: Neural Correlates of Visually Induced Analgesia , 2012, The Journal of Neuroscience.

[89]  Amishi P. Jha,et al.  Viewing facial expressions of pain engages cortical areas involved in the direct experience of pain , 2005, NeuroImage.

[90]  Mel Slater,et al.  The Sense of Embodiment in Virtual Reality , 2012, PRESENCE: Teleoperators and Virtual Environments.

[91]  A. Maravita,et al.  The visual size of one׳s own hand modulates pain anticipation and perception , 2014, Neuropsychologia.

[92]  S. Morioka,et al.  Negative Body Image Associated with Changes in the Visual Body Appearance Increases Pain Perception , 2014, PloS one.

[93]  P. Haggard,et al.  Viewing the body modulates both pain sensations and pain responses , 2016, Experimental Brain Research.

[94]  R. Passingham,et al.  That's My Hand! Activity in Premotor Cortex Reflects Feeling of Ownership of a Limb , 2004, Science.

[95]  Maria V. Sanchez-Vives,et al.  The body fades away: investigating the effects of transparency of an embodied virtual body on pain threshold and body ownership , 2015, Scientific Reports.

[96]  R. Treede,et al.  The Kyoto protocol of IASP Basic Pain Terminology , 2008, PAIN®.