The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

[1]  T. Hunter,et al.  Prolyl isomerase Pin1 in cancer , 2014, Cell Research.

[2]  J. Lieberman,et al.  Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. , 2014, Cancer research.

[3]  S. Bicciato,et al.  Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast , 2013, EMBO molecular medicine.

[4]  J. Goldenring.  A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis , 2013, Nature Reviews Cancer.

[5]  James Lee,et al.  Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells , 2013, Journal of Cell Science.

[6]  H. Shih,et al.  SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. , 2013, Cancer research.

[7]  Gabriela Kalna,et al.  ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation , 2013, Cell stem cell.

[8]  S. Lok,et al.  Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. , 2012, Cancer research.

[9]  E. Canaani,et al.  TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication , 2012, Cell.

[10]  R. Roskoski.  ERK1/2 MAP kinases: structure, function, and regulation. , 2012, Pharmacological research.

[11]  Benjamin E. Gross,et al.  The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.

[12]  F. Markowetz,et al.  The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups , 2012, Nature.

[13]  Stephen J. Elledge,et al.  Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop , 2012, Nature Medicine.

[14]  L. Nicholson,et al.  Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease , 2012, Cell.

[15]  C. Perou,et al.  Defining the cellular precursors to human breast cancer , 2011, Proceedings of the National Academy of Sciences.

[16]  Min-Jung Kim,et al.  The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem‐like cells , 2011, FEBS letters.

[17]  M. Sabel,et al.  EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development , 2011, Modern Pathology.

[18]  A. Goate,et al.  Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. , 2011, Molecular cell.

[19]  Yi Zheng,et al.  Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity , 2011, PloS one.

[20]  W. Woodward,et al.  EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. , 2011, Cancer cell.

[21]  A. Huang,et al.  Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization , 2011, BMC Cancer.

[22]  J. Blenis,et al.  ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. , 2010, Molecular cell.

[23]  T. Yeatman,et al.  Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. , 2010, The Journal of clinical investigation.

[24]  Derek Y. Chiang,et al.  The landscape of somatic copy-number alteration across human cancers , 2010, Nature.

[25]  Julia Schüler,et al.  The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs , 2009, Nature Cell Biology.

[26]  P. Fortina,et al.  p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo , 2009, Proceedings of the National Academy of Sciences.

[27]  M. Wicha.  Targeting breast cancer stem cells. , 2009, Breast.

[28]  H. Stenmark.  Rab GTPases as coordinators of vesicle traffic , 2009, Nature Reviews Molecular Cell Biology.

[29]  A. Nobel,et al.  Supervised risk predictor of breast cancer based on intrinsic subtypes. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[30]  H. Kölbl,et al.  The humoral immune system has a key prognostic impact in node-negative breast cancer. , 2008, Cancer research.

[31]  Siew Hong Leong,et al.  Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. , 2008, Cancer research.

[32]  Daniel Medina,et al.  Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. , 2008, Cancer research.

[33]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[34]  J. Lieberman,et al.  let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells , 2007, Cell.

[35]  Daniel Birnbaum,et al.  ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. , 2007, Cell stem cell.

[36]  Xiao Zhen Zhou,et al.  The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease , 2007, Nature Reviews Molecular Cell Biology.

[37]  Suzanne Schubbert,et al.  Hyperactive Ras in developmental disorders and cancer , 2007, Nature Reviews Cancer.

[38]  T. Barrette,et al.  Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. , 2007, Neoplasia.

[39]  Q. Zhan,et al.  Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. , 2006, Cancer research.

[40]  Haiyan I. Li,et al.  Purification and unique properties of mammary epithelial stem cells , 2006, Nature.

[41]  Jeffrey T. Chang,et al.  Oncogenic pathway signatures in human cancers as a guide to targeted therapies , 2006, Nature.

[42]  J. Gutkind,et al.  Regulation of the Transcriptional Activity of c-Fos by ERK , 2005, Journal of Biological Chemistry.

[43]  H. Clevers,et al.  Wnt signalling in stem cells and cancer , 2005, Nature.

[44]  G. Dontu,et al.  Survival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasia , 2005, Journal of Mammary Gland Biology and Neoplasia.

[45]  G. Mills,et al.  The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers , 2004, Nature Medicine.

[46]  B. Dynlacht,et al.  A novel mechanism for mitogen-activated protein kinase localization. , 2004, Molecular biology of the cell.

[47]  R. Dickinson,et al.  Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal* , 2004, Journal of Biological Chemistry.

[48]  W. Mobley,et al.  NGF Signaling in Sensory Neurons Evidence that Early Endosomes Carry NGF Retrograde Signals , 2003, Neuron.

[49]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[50]  William C Hahn,et al.  Lentivirus-delivered stable gene silencing by RNAi in primary cells. , 2003, RNA.

[51]  Lee Bardwell,et al.  Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. , 2003, The Biochemical journal.

[52]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Sam W. Lee,et al.  PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells , 2002, Molecular and Cellular Biology.

[54]  J. B. Sajous,et al.  Ras signalling on the endoplasmic reticulum and the Golgi , 2002, Nature Cell Biology.

[55]  M. Callanan,et al.  Graphical Representation of a Generalized Linear Model-Based Statistical Test Estimating the Fit of the Single-Hit Poisson Model to Limiting Dilution Assays , 2001, The Journal of Immunology.

[56]  K. Anderson,et al.  Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway , 2001, Nature.

[57]  Tianhua Niu,et al.  Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c‐Jun towards cyclin D1 , 2001, The EMBO journal.

[58]  T. Hunter,et al.  Oncogenic kinase signalling , 2001, Nature.

[59]  W. Hahn,et al.  Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. , 2001, Genes & development.

[60]  Masafumi Nakamura,et al.  Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC , 2001, Nature Cell Biology.

[61]  H. Andersson,et al.  ERGIC-53 and traffic in the secretory pathway. , 2000, Journal of cell science.

[62]  E. Nishida,et al.  A conserved docking motif in MAP kinases common to substrates, activators and regulators , 2000, Nature Cell Biology.

[63]  M. Kirschner,et al.  Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. , 1997, Science.

[64]  W. Balch,et al.  Rab2 Is Essential for the Maturation of Pre-Golgi Intermediates* , 1996, The Journal of Biological Chemistry.

[65]  T. Hunter,et al.  A human peptidyl–prolyl isomerase essential for regulation of mitosis , 1996, Nature.