Epigenetic adjuvants: durable reprogramming of the innate immune systemsy with adjuvants.

[1]  Madeleine K. D. Scott,et al.  A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice , 2022, Nature communications.

[2]  K. Bruxvoort,et al.  Recombinant adjuvanted zoster vaccine and reduced risk of COVID-19 diagnosis and hospitalization in older adults , 2021, medRxiv.

[3]  A. Sher,et al.  Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge , 2021, bioRxiv.

[4]  K. Mills,et al.  The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research , 2021, Frontiers in Immunology.

[5]  Mark M. Davis,et al.  Systems vaccinology of the BNT162b2 mRNA vaccine in humans , 2021, Nature.

[6]  Mark M. Davis,et al.  The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination , 2021, Cell.

[7]  B. Pulendran,et al.  Emerging concepts in the science of vaccine adjuvants , 2021, Nature Reviews Drug Discovery.

[8]  K. Ozato,et al.  Innate Immune Memory in Hematopoietic Stem/Progenitor Cells: Myeloid-Biased Differentiation and the Role of Interferon , 2021, Frontiers in Immunology.

[9]  Allison M. Owen,et al.  TLR Agonists as Mediators of Trained Immunity: Mechanistic Insight and Immunotherapeutic Potential to Combat Infection , 2021, Frontiers in Immunology.

[10]  P. Dormitzer,et al.  Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine , 2020, The New England journal of medicine.

[11]  L. Joosten,et al.  BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils , 2020, Cell reports.

[12]  M. Netea,et al.  Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly , 2020, Cell.

[13]  S. Smeekens,et al.  Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study , 2020, Cell Reports Medicine.

[14]  J. Mascola,et al.  An mRNA Vaccine against SARS-CoV-2 — Preliminary Report , 2020, The New England journal of medicine.

[15]  B. Pulendran,et al.  3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates , 2020, Science Immunology.

[16]  M. Oosting,et al.  BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment , 2020, Cell Host & Microbe.

[17]  Mihai G. Netea,et al.  BCG-induced trained immunity: can it offer protection against COVID-19? , 2020, Nature Reviews Immunology.

[18]  M. Netea,et al.  Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection , 2020, Cell.

[19]  I. Amit,et al.  C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells. , 2020, Cell stem cell.

[20]  R. Xavier,et al.  Defining trained immunity and its role in health and disease , 2020, Nature Reviews Immunology.

[21]  J. Berzofsky,et al.  Myeloid Cell-Mediated Trained Innate Immunity in Mucosal AIDS Vaccine Development , 2020, Frontiers in Immunology.

[22]  M. Netea,et al.  Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections , 2019, The Journal of infectious diseases.

[23]  P. González,et al.  BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design , 2019, Front. Immunol..

[24]  M. Oosting,et al.  β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32. , 2019, Cell reports.

[25]  M. Netea,et al.  The influence of neonatal Bacille Calmette-Guérin (BCG) immunisation on heterologous vaccine responses in infants. , 2019, Vaccine.

[26]  M. Netea,et al.  Outcomes of controlled human malaria infection after BCG vaccination , 2019, Nature Communications.

[27]  Sangkyu Park,et al.  CpG-DNA exerts antibacterial effects by protecting immune cells and producing bacteria-reactive antibodies , 2018, Scientific Reports.

[28]  J. Schertzer,et al.  Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity , 2018, Cell.

[29]  K. Sakaguchi,et al.  Interferon stimulation creates chromatin marks and establishes transcriptional memory , 2018, Proceedings of the National Academy of Sciences.

[30]  R. Horst,et al.  Metabolic Induction of Trained Immunity through the Mevalonate Pathway , 2018, Cell.

[31]  Irah L. King,et al.  BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis , 2018, Cell.

[32]  M. Oosting,et al.  Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming , 2018, Cell.

[33]  L. Joosten,et al.  Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity , 2018, Cell.

[34]  R. Xavier,et al.  BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. , 2018, Cell host & microbe.

[35]  A Two-Dose Hepatitis B Vaccine for Adults (Heplisav-B). , 2018, JAMA.

[36]  R. A. van den Berg,et al.  Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans , 2017, Front. Immunol..

[37]  A. Rodrigues,et al.  Early BCG-Denmark and Neonatal Mortality Among Infants Weighing <2500 g: A Randomized Controlled Trial , 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[38]  A. Salazar,et al.  Prophylactic and therapeutic intranasal administration with an immunomodulator, Hiltonol® (Poly IC:LC), in a lethal SARS-CoV-infected BALB/c mouse model , 2016, Antiviral Research.

[39]  Richard A. Notebaart,et al.  Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. , 2016, Cell metabolism.

[40]  Vivien A. C. Schoonenberg,et al.  β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance , 2016, Cell.

[41]  J. Galson,et al.  Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination , 2016, Scientific Reports.

[42]  L. Joosten,et al.  Long‐term in vitro and in vivo effects of γ‐irradiated BCG on innate and adaptive immunity , 2015, Journal of leukocyte biology.

[43]  A. Rodrigues,et al.  The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[44]  R. Xavier,et al.  Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity , 2014, Science.

[45]  R. Xavier,et al.  mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity , 2014, Science.

[46]  P. Naud,et al.  Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine , 2014, Human vaccines & immunotherapeutics.

[47]  Trees Jansen,et al.  Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors , 2014, Clinical and Vaccine Immunology.

[48]  D. Smee,et al.  Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand , 2013, Journal of Innate Immunity.

[49]  R. Xavier,et al.  Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity , 2013, Journal of Innate Immunity.

[50]  R. Xavier,et al.  Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes , 2012, Proceedings of the National Academy of Sciences.

[51]  Jincun Zhao,et al.  Intranasal Treatment with Poly(I·C) Protects Aged Mice from Lethal Respiratory Virus Infections , 2012, Journal of Virology.

[52]  R. Xavier,et al.  Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. , 2012, Cell host & microbe.

[53]  J. McVernon,et al.  Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice. , 2012, Molecular pharmaceutics.

[54]  Peter Aaby,et al.  Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial , 2010, BMJ : British Medical Journal.

[55]  M. Sodemann,et al.  Vaccinia scars associated with better survival for adults. An observational study from Guinea-Bissau. , 2006, Vaccine.

[56]  Houping Ni,et al.  Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. , 2005, Immunity.

[57]  M. Faccini,et al.  Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly. , 1999, Vaccine.

[58]  H. Whittle,et al.  Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries , 1995, BMJ.

[59]  R. Ganguly,et al.  Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guérin. , 1977, The Journal of infectious diseases.