Chemical Protein Synthesis (CPS) Meeting 2013

Building bonds in Vienna: The Chemical Protein Synthesis meeting recently took place at the University of Vienna, Austria. This report describes the event and highlights the science presented over the four days.

[1]  P. Seeberger,et al.  Eine allgemeine Methode zur Herstellung von GPI‐Membranankern am Beispiel der Totalsynthese des “Low‐molecular‐weight‐Antigens” von Toxoplasma gondii , 2011 .

[2]  A. Schier,et al.  Optical Control of Metabotropic Glutamate Receptors , 2013, Nature Neuroscience.

[3]  Todd O Yeates,et al.  Racemic protein crystallography. , 2012, Annual review of biophysics.

[4]  L. Abrahmsén,et al.  A Native Chemical Ligation Approach for Combinatorial Assembly of Affibody Molecules , 2012, Chembiochem : a European journal of chemical biology.

[5]  M. Engelhard,et al.  Native chemical ligation in dimethylformamide can be performed chemoselectively without racemization , 2012, Journal of peptide science : an official publication of the European Peptide Society.

[6]  Brendan L Wilkinson,et al.  Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin. , 2012, Chemical communications.

[7]  D. Schwarzer,et al.  Directed evolution of sortase A mutants with altered substrate selectivity profiles. , 2011, Journal of the American Chemical Society.

[8]  O. Melnyk,et al.  Sequential native peptide ligation strategies for total chemical protein synthesis. , 2012, Chemical Society reviews.

[9]  E. Krause,et al.  Site-specific PEGylation of proteins by a Staudinger-phosphite reaction , 2010 .

[10]  Yukishige Ito,et al.  Chemical synthesis of intentionally misfolded homogeneous glycoprotein: a unique approach for the study of glycoprotein quality control. , 2012, Journal of the American Chemical Society.

[11]  W. S. Horne,et al.  Design strategies for the sequence-based mimicry of side-chain display in protein β-sheets by α/β-peptides. , 2012, Journal of the American Chemical Society.

[12]  C. Becker,et al.  Exploring the effect of native and artificial peptide modifications on silaffin induced silica precipitation , 2012 .

[13]  Swati Tyagi,et al.  Click strategies for single-molecule protein fluorescence. , 2012, Journal of the American Chemical Society.

[14]  Jacob M. Goldberg,et al.  Thioamides as fluorescence quenching probes: minimalist chromophores to monitor protein dynamics. , 2010, Journal of the American Chemical Society.

[15]  H. Mootz,et al.  Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition. , 2013, Bioorganic & medicinal chemistry.

[16]  S. Sidhu,et al.  Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography , 2012, Proceedings of the National Academy of Sciences.

[17]  P. Seeberger,et al.  A general method for synthesis of GPI anchors illustrated by the total synthesis of the low-molecular-weight antigen from Toxoplasma gondii. , 2011, Angewandte Chemie.

[18]  Lei Liu,et al.  Protein chemical synthesis by ligation of peptide hydrazides. , 2011, Angewandte Chemie.

[19]  M. Meldal,et al.  Simultaneous “One Pot” Expressed Protein Ligation and CuI‐Catalyzed Azide/Alkyne Cycloaddition for Protein Immobilization , 2011, Chembiochem : a European journal of chemical biology.

[20]  A. Brik,et al.  Chemical synthesis of ubiquitinated peptides with varying lengths and types of ubiquitin chains to explore the activity of deubiquitinases. , 2012, Angewandte Chemie.

[21]  Igor L. Medintz,et al.  Nanoparticle targeting to neurons in a rat hippocampal slice culture model , 2012, ASN neuro.

[22]  J. Bode,et al.  Chemical protein synthesis by chemoselective α-ketoacid-hydroxylamine (KAHA) ligations with 5-oxaproline. , 2012, Angewandte Chemie.

[23]  H. Lashuel,et al.  Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. , 2011, Angewandte Chemie.

[24]  B. G. Davis,et al.  Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection , 2012, Nature Communications.

[25]  Yaowen Wu,et al.  Semisynthesis of Prenylated Rab GTPases by Click Ligation , 2011, Chembiochem : a European journal of chemical biology.

[26]  J. Scheuermann,et al.  A traceless vascular-targeting antibody-drug conjugate for cancer therapy. , 2012, Angewandte Chemie.

[27]  C. Unverzagt,et al.  Convergent solid-phase synthesis of N-glycopeptides facilitated by pseudoprolines at consensus-sequence Ser/Thr residues. , 2012, Angewandte Chemie.

[28]  M. Jaskólski,et al.  Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. , 1989, Science.

[29]  R. B. Merrifield.  Solid phase peptide synthesis. I. the synthesis of a tetrapeptide , 1963 .

[30]  O. Seitz,et al.  Bioorthogonal reactions challenged: DNA templated native chemical ligation during PCR , 2013 .