Development of poorly differentiated invasive squamous cell carcinoma in giant Bowen’s disease: a case report with dermatoscopy

Bowen’s disease (BD) is an in situ form of squamous cell carcinoma (SCC), often occurring in the chronically UV-damaged skin of elderly people. The risk of progression of BD to invasive SCC varies between 3% and 5%, and one-third of invasive tumors may metastasize. Herein we discuss the dermatoscopic findings of a case of giant Bowen’s disease, which progressed to poorly differentiated invasive SCC.

[1]  I. Zalaudek,et al.  Dermoscopy of squamous cell carcinoma and keratoacanthoma. , 2012, Archives of dermatology.

[2]  Harald Kittler,et al.  Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model. , 2012, Journal of the American Academy of Dermatology.

[3]  Harald Kittler,et al.  Dermatoscopy of pigmented Bowen's disease. , 2010, Journal of the American Academy of Dermatology.

[4]  H. Walling,et al.  Variations in presentation of squamous cell carcinoma in situ (Bowen's disease) in immunocompromised patients. , 2008, Journal of the American Academy of Dermatology.

[5]  D. Eedy,et al.  Guidelines for management of Bowen's disease: 2006 update , 2007, The British journal of dermatology.

[6]  T. Ohtsuka,et al.  Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's disease and squamous cell carcinoma of the skin , 2006, The Journal of dermatology.

[7]  H. Comber,et al.  A population‐based study of skin cancer incidence and prevalence in renal transplant recipients , 2006, The British journal of dermatology.

[8]  R Hofmann-Wellenhof,et al.  Dermoscopy of Bowen's disease , 2004, The British journal of dermatology.

[9]  A. Cesinaro,et al.  Detection of Human Papillomavirus in Extragenital Bowen's Disease Using in Situ Hybridization and Polymerase Chain Reaction , 1995, The American Journal of dermatopathology.

[10]  J. L. Stone,et al.  Bowen's disease (squamous cell carcinoma in situ) in Kauai, Hawaii. A population-based incidence report. , 1994, Journal of the American Academy of Dermatology.

[11]  R. Rosen,et al.  Cutaneous Bowen's disease. An analysis of 1001 cases according to age, sex, and site. , 1992, Journal of the American Academy of Dermatology.

[12]  Philip R. Cohen.  Bowen's disease: squamous cell carcinoma in situ. , 1991, American family physician.

[13]  J. Tschen,et al.  Detection of human papillomavirus in nongenital Bowen's disease by in situ DNA hybridization. , 1990, Archives of dermatology.

[14]  G. Kao.  Carcinoma arising in Bowen's disease. , 1986, Archives of dermatology.

[15]  R. Goltz,et al.  An association between Bowen's disease and internal cancer. , 1961, Archives of dermatology.