A longitudinal study of thyroid autoantibodies in pregnancy: the importance of test timing

Thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb) are frequently measured to investigate thyroid dysfunction in pregnancy. Despite the recognized fall of these autoantibodies in pregnancy, there is limited guidance on the timing of such testing. We assessed optimal test timing of TPOAb/TGAb for the detection of Hashimoto's thyroiditis and post‐partum thyroid dysfunction (PPTD).

[1]  S. Waisbren,et al.  "Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child" (1999), by James E. Haddow et al. , 2014 .

[2]  Zhong X. Lu,et al.  Longitudinal assessment of thyroid function in pregnancy , 2013, Annals of clinical biochemistry.

[3]  T. Davies,et al.  Thyroid Autoantibodies in Pregnancy: Their Role, Regulation and Clinical Relevance , 2013, Journal of thyroid research.

[4]  A. Leung Thyroid function in pregnancy. , 2012, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[5]  R. Negro,et al.  2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. , 2011, Thyroid : official journal of the American Thyroid Association.

[6]  K. Zaletel,et al.  Thyroid physiology and autoimmunity in pregnancy and after delivery , 2011, Expert review of clinical immunology.

[7]  R. Negro,et al.  Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy. , 2010, The Journal of clinical endocrinology and metabolism.

[8]  S. Mandel,et al.  Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. , 2007, The Journal of clinical endocrinology and metabolism.

[9]  D. Dazzi,et al.  Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. , 2006, The Journal of clinical endocrinology and metabolism.

[10]  P. Smyth,et al.  Sequential studies on thyroid antibodies during pregnancy. , 2005, Thyroid : official journal of the American Thyroid Association.

[11]  D. Glinoer The regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. , 2004, Best practice & research. Clinical endocrinology & metabolism.

[12]  M. Parmar Diagnosis and management of hyperthyroidism and hypothyroidism , 2004, The Medical journal of Australia.

[13]  W Harry Hannon,et al.  Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). , 2002, The Journal of clinical endocrinology and metabolism.

[14]  H. Drexhage,et al.  Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. , 2001, Endocrine reviews.

[15]  S. Waisbren,et al.  Relation of severity of maternal hypothyroidism to cognitive development of offspring , 2001, Journal of medical screening.

[16]  R. Smallridge Postpartum thyroid disease A model of immunologic dysfunction , 2000 .

[17]  T. Lambert,et al.  Postpartum thyroid dysfunction: clinical assessment and relationship to psychiatric affective morbidity , 1999, Clinical endocrinology.

[18]  W. Wiersinga,et al.  Prediction of post partum thyroid dysfunction: can it be improved? , 1998, European journal of endocrinology.

[19]  D. Glinoer,et al.  Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. , 1994, The Journal of clinical endocrinology and metabolism.

[20]  S. Wallenstein,et al.  A prospective study of lymphocyte-initiated immunosuppression in normal pregnancy: evidence of a T-cell etiology for postpartum thyroid dysfunction. , 1992, The Journal of clinical endocrinology and metabolism.

[21]  R. Cobin,et al.  Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. , 1990, JAMA.

[22]  R. H. Parker,et al.  Thyroid antibodies during pregnancy and in the newborn. , 1961, The Journal of clinical endocrinology and metabolism.

[23]  R. Negro,et al.  Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. , 2011, Thyroid : official journal of the American Thyroid Association.

[24]  O. Levalle,et al.  Overt and subclinical hypothyroidism complicating pregnancy. , 2002, Thyroid : official journal of the American Thyroid Association.

[25]  J. Gónzalez-Buitrago,et al.  Biological variability of thyroid autoantibodies (anti‐TPO and anti‐Tg) in clinically and biochemically stable patients with autoimmune thyroid disease , 2002, Journal of clinical laboratory analysis.

[26]  K. Kotani,et al.  Changes of serum anti-thyroid antibodies during and after pregnancy in autoimmune thyroid diseases. , 1978, Clinical and experimental immunology.

[27]  C. Eastman,et al.  5: Diagnosis and Management of Hyperthyroidism and Hypothyroidism Mja Practice Essentials Endocrinology , 2022 .