Genetic Basis of Human Breast Cancer Metastasis

[1]  M. Takata,et al.  Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. , 2001, Cancer research.

[2]  F. Peale,et al.  Identification of an angiogenic mitogen selective for endocrine gland endothelium , 2001, Nature.

[3]  P. Emson,et al.  AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1* , 2001, The Journal of Biological Chemistry.

[4]  O. Nishimura,et al.  Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor , 2001, Nature.

[5]  P. O’Connell,et al.  Advances in Brief Loss of Heterozygosity Events Impeding Breast Cancer Metastasis Contain the MTA 1 Gene 1 , 2001 .

[6]  Ximing J. Yang,et al.  Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. , 2001, Cancer research.

[7]  C. Osborne,et al.  Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition. , 2001, Cancer research.

[8]  D. Welch,et al.  Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. , 2001, Cancer research.

[9]  M. Herlyn,et al.  Role of cadherins and matrixins in melanoma , 2001, Current opinion in oncology.

[10]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[11]  D. Boyd,et al.  KiSS-1 Represses 92-kDa Type IV Collagenase Expression by Down-regulating NF-κB Binding to the Promoter as a Consequence of IκBα-induced Block of p65/p50 Nuclear Translocation* , 2001, The Journal of Biological Chemistry.

[12]  S. Zucker,et al.  Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment , 2000, Oncogene.

[13]  T. A. Graham,et al.  Crystal Structure of a β-Catenin/Tcf Complex , 2000, Cell.

[14]  P. Furth,et al.  Reduced mammary tumor progression in WAP-TAg/WAP-maspin bitransgenic mice , 2000, Oncogene.

[15]  L. Van Aelst,et al.  Rho GTPases: signaling, migration, and invasion. , 2000, Experimental cell research.

[16]  C. Rinker-Schaeffer,et al.  Metastasis-suppressor genes: a review and perspective on an emerging field. , 2000, Journal of the National Cancer Institute.

[17]  S. Merajver,et al.  RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. , 2000, Cancer research.

[18]  K. Brew,et al.  TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix* , 2000, The Journal of Biological Chemistry.

[19]  S. Clark,et al.  Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines. , 2000, Cancer letters.

[20]  Careen K. Tang,et al.  KAI1 protein is down-regulated during the progression of human breast cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[21]  D. Welch,et al.  Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. , 2000, Cancer research.

[22]  A. Puisieux,et al.  Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage , 2000, Oncogene.

[23]  M. Hendrix,et al.  Epigenetic silencing of maspin gene expression in human breast cancers , 2000, International journal of cancer.

[24]  J. Bonventre,et al.  Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells. , 2000, Cancer Research.

[25]  R. Kadner,et al.  Signaling Components in Bacterial Locomotion and Sensory Reception , 2000, Journal of bacteriology.

[26]  K. Brew,et al.  Tissue inhibitors of metalloproteinases: evolution, structure and function. , 2000, Biochimica et biophysica acta.

[27]  B. Fingleton,et al.  Matrix metalloproteinases: biologic activity and clinical implications. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  Bonnie F. Sloane,et al.  Unraveling the role of proteases in cancer. , 2000, Clinica chimica acta; international journal of clinical chemistry.

[29]  M. G. Paggi,et al.  nm23: Unraveling its biological function in cell differentiation , 2000, Journal of cellular physiology.

[30]  O. Volpert,et al.  Maspin is an angiogenesis inhibitor , 2000, Nature Medicine.

[31]  J. Herman,et al.  Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression* , 2000, The Journal of Biological Chemistry.

[32]  G. Li,et al.  Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. , 1999, Cancer research.

[33]  E. Fearon,et al.  Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements , 1999, Oncogene.

[34]  S. Kiley,et al.  Increased protein kinase Cδ in mammary tumor cells: relationship to transformation and metastatic progression , 1999, Oncogene.

[35]  W. Stadler,et al.  Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. , 1999, Cancer research.

[36]  M. Webber,et al.  Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. , 1999, Cancer research.

[37]  C. Rinker-Schaeffer,et al.  What defines a useful marker of metastasis in human cancer? , 1999, Journal of the National Cancer Institute.

[38]  A. Bird,et al.  Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. , 1999, Genes & development.

[39]  S. Kiley,et al.  Protein Kinase C δ Involvement in Mammary Tumor Cell Metastasis , 1999 .

[40]  G. Turner,et al.  Are selectins involved in metastasis? , 1999, Clinical & Experimental Metastasis.

[41]  A. Gnirke,et al.  New genes potentially involved in breast cancer metastasis. , 1999, Anticancer research.

[42]  A. Grothey,et al.  Low E-cadherin and β-catenin expression correlates with increased spontaneous and artificial lung metastases of murine carcinomas , 1999, Clinical & Experimental Metastasis.

[43]  V. Weiss,et al.  Signalling pathways in two-component phosphorelay systems. , 1999, Trends in microbiology.

[44]  M. Duffy,et al.  High levels of tissue inhibitor of metalloproteinase‐1 predict poor outcome in patients with breast cancer , 1999, International journal of cancer.

[45]  H. Stein,et al.  ©1999 Cancer Research Campaign Article no. bjoc.1998.0202 , 2022 .

[46]  G. Christofori,et al.  The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. , 1999, Trends in biochemical sciences.

[47]  J. Lee,et al.  Expression of osteopontin and osteonectin in breast cancer. , 1998, Journal of Korean medical science.

[48]  Weidong Wang,et al.  NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. , 1998, Molecular cell.

[49]  B. Weissman,et al.  Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). , 1998, Genomics.

[50]  W. Stadler,et al.  Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases. , 1998, Cancer research.

[51]  J. F. Harris,et al.  Osteopontin expression in a group of lymph node negative breast cancer patients , 1998, International journal of cancer.

[52]  M. Fiscella,et al.  Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis , 1998, Oncogene.

[53]  C. Kumar,et al.  Signaling by integrin receptors , 1998, Oncogene.

[54]  K. Miura,et al.  The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[55]  D. Welch,et al.  Genetic and epigenetic regulation of human breast cancer progression and metastasis , 1998 .

[56]  N. Kohno,et al.  Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients. , 1998, The American journal of pathology.

[57]  N. Colburn,et al.  Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells. , 1998, Carcinogenesis.

[58]  Gerhard Christofori,et al.  A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.

[59]  J. Barrett,et al.  Correlation between reduction of metastasis in the MDA‐MB‐435 model system and increased expression of the Kai‐1 protein , 1998, Molecular carcinogenesis.

[60]  B. Weissman,et al.  KAI1, a putative marker for metastatic potential in human breast cancer. , 1997, Cancer letters.

[61]  E Ruoslahti,et al.  Integrins and anoikis. , 1997, Current opinion in cell biology.

[62]  L. Matrisian,et al.  Changing views of the role of matrix metalloproteinases in metastasis. , 1997, Journal of the National Cancer Institute.

[63]  J. Nesland,et al.  High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[64]  M. Duffy,et al.  The urokinase‐type plasminogen activator system in cancer metastasis: A review , 1997, International journal of cancer.

[65]  J. H. Lee,et al.  Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. , 1997, Cancer research.

[66]  D. Welch.  Technical considerations for studying cancer metastasis in vivo , 1997, Clinical & Experimental Metastasis.

[67]  F. O'Malley,et al.  Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[68]  L. Jin,et al.  Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[69]  G. Berx,et al.  E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. , 1996, Oncogene.

[70]  J. Barrett,et al.  KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. , 1995, Science.

[71]  J. Barrett,et al.  Differential suppression of mammary and prostate cancer metastasis by human chromosomes 17 and 11. , 1994, Cancer research.

[72]  G. Nicolson,et al.  A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. , 1994, The Journal of biological chemistry.

[73]  T. Springer.  Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm , 1994, Cell.

[74]  P. Steeg,et al.  A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. , 1993, The Journal of biological chemistry.

[75]  S. J. Flint,et al.  Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. , 1993, Science.

[76]  I. Fidler,et al.  Genetic control of cancer metastasis. , 1990, Journal of the National Cancer Institute.

[77]  J. Price,et al.  Studies of human breast cancer metastasis using nude mice , 1990, Cancer and Metastasis Reviews.

[78]  J. Price,et al.  Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. , 1990, Cancer research.

[79]  G. Nicolson,et al.  Heterogeneity in the sensitivities of the 13762NF rat mammary adenocarcinoma cell clones to cytolysis mediated by extra- and intratumoral macrophages. , 1985, Cancer research.

[80]  I. Fidler,et al.  Metastatic behavior of human tumor cell lines grown in the nude mouse. , 1984, Cancer research.

[81]  H. D. Liggitt,et al.  Interaction of metastatic tumor cells with bovine lens capsule basement membrane. , 1984, Cancer research.

[82]  S. Winawer,et al.  A model for human colon carcinoma evolution based on the differential response of cultured preneoplastic, premalignant, and malignant cells to 12-O-tetradecanoylphorbol-13-acetate. , 1984, Cancer research.

[83]  G. Nicolson,et al.  Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma. , 1982, Journal of the National Cancer Institute.

[84]  D. Welch,et al.  Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate , 2004, Clinical & Experimental Metastasis.

[85]  A. Raz,et al.  Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis , 2004, Cancer and Metastasis Reviews.

[86]  M. Toi,et al.  Metalloproteinases and tissue inhibitors of metalloproteinases , 2004, Breast Cancer Research and Treatment.

[87]  S. Kiley,et al.  Protein kinase C delta involvement in mammary tumor cell metastasis. , 1999, Cancer research.

[88]  John G. Collard,et al.  Rho-like GTPases: their role in epithelial cell-cell adhesion and invasion. , 1999, European journal of cancer.

[89]  P. Steeg,et al.  Nm23 and tumour metastasis: basic and translational advances. , 1998, Biochemical Society symposium.

[90]  L. Liotta,et al.  Autotaxin, tumor motility-stimulating exophosphodiesterase. , 1997, Advances in enzyme regulation.

[91]  A. Oates,et al.  The role of osteopontin in tumorigenesis and metastasis. , 1997, Invasion & metastasis.

[92]  M. Hendrix,et al.  Maspin. A tumor suppressing serpin. , 1997, Advances in experimental medicine and biology.

[93]  A. Chambers,et al.  Ras-responsive genes and tumor metastasis. , 1993, Critical reviews in oncogenesis.