Clinical and Genetic Determinants of Varicose Veins: Prospective, Community-Based Study of ≈500000 Individuals

[1]  E. Ingelsson,et al.  Bioimpedance and New‐Onset Heart Failure: A Longitudinal Study of >500 000 Individuals From the General Population , 2017, bioRxiv.

[2]  Mei-Ching Lee,et al.  Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease , 2018, JAMA.

[3]  Erdogan Taskesen,et al.  Functional mapping and annotation of genetic associations with FUMA , 2017, Nature Communications.

[4]  J. Sundquist,et al.  Body Height and Incident Risk of Venous Thromboembolism: A Cosibling Design , 2017, Circulation. Cardiovascular genetics.

[5]  J. Fareed,et al.  Do blood constituents in varicose veins differ from the systemic blood constituents? , 2015, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[6]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[7]  J. Hirschhorn,et al.  Biological interpretation of genome-wide association studies using predicted gene functions , 2015, Nature Communications.

[8]  Carson C Chow,et al.  Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.

[9]  N. Yuldasheva,et al.  Piezo1 integration of vascular architecture with physiological force , 2014, Nature.

[10]  J. Sundquist,et al.  Venous Thromboembolism and Varicose Veins Share Familial Susceptibility: A Nationwide Family Study in Sweden , 2014, Journal of the American Heart Association.

[11]  Fatimah Ibrahim,et al.  The Theory and Fundamentals of Bioimpedance Analysis in Clinical Status Monitoring and Diagnosis of Diseases , 2014, Sensors.

[12]  Alois Knoll,et al.  Gradient boosting machines, a tutorial , 2013, Front. Neurorobot..

[13]  Ellen T. Gelfand,et al.  The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.

[14]  A. Hamdan Management of varicose veins and venous insufficiency. , 2012, JAMA.

[15]  J. Szecsenyi,et al.  Varicose veins are a risk factor for deep venous thrombosis in general practice patients. , 2012, VASA. Zeitschrift fur Gefasskrankheiten.

[16]  A. Davies,et al.  A review of familial, genetic, and congenital aspects of primary varicose vein disease. , 2012, Circulation. Cardiovascular genetics.

[17]  A. V. Van rij,et al.  Evidence for a genetic role in varicose veins and chronic venous insufficiency , 2012, Phlebology.

[18]  T. Luukkaala,et al.  Effect of family history on the risk of varicose veins is affected by differential misclassification. , 2010, Journal of clinical epidemiology.

[19]  Andrew D. Johnson,et al.  Genome-wide association study of blood pressure and hypertension , 2009, Nature Genetics.

[20]  C. Fegan,et al.  Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls. , 2009, Journal of vascular surgery.

[21]  T. Luukkaala,et al.  Persons With Varicose Veins Have a High Subsequent Incidence of Arterial Disease: A Population-Based Study in Tampere, Finland , 2007, Angiology.

[22]  G. Schmid-Schönbein,et al.  Chronic venous disease. , 2006, Minerva cardioangiologica.

[23]  Monte M Winslow,et al.  Calcineurin/NFAT signaling in osteoblasts regulates bone mass. , 2006, Developmental cell.

[24]  S. Tognazzo,et al.  The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis. , 2006, Free radical biology & medicine.

[25]  J. Beebe-Dimmer,et al.  The epidemiology of chronic venous insufficiency and varicose veins. , 2005, Annals of epidemiology.

[26]  H. Maricq,et al.  Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: a population-based study in France. , 2004, Journal of vascular surgery.

[27]  P. Vokonas,et al.  Are Varicose Veins a Marker for Susceptibility to Coronary Heart Disease in Men? Results from the Normative Aging Study , 2004, Annals of vascular surgery.

[28]  A. Busjahn,et al.  Heritability of Venous Function in Humans , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[29]  P. Allan,et al.  Lifestyle factors and the risk of varicose veins: Edinburgh Vein Study. , 2003, Journal of clinical epidemiology.

[30]  Feng Chen,et al.  Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature , 2001, Cell.

[31]  A. Joyner,et al.  Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development. , 2001, Developmental biology.

[32]  M. Alhenc-Gelas,et al.  Thrombomodulin Promoter Mutations, Venous Thrombosis, and Varicose Veins , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[33]  F. Berrino,et al.  High endogenous estradiol is associated with increased venous distensibility and clinical evidence of varicose veins in menopausal women. , 2000, Journal of vascular surgery.

[34]  C. Abbott,et al.  Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice , 2000, Nature Genetics.

[35]  T. Baglin,et al.  Risk of venous thromboembolism associated with the common hereditary haemochromatosis Hfe gene (C282Y) mutation , 1999, British journal of haematology.

[36]  E. Schwartz,et al.  Prevalence of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with varicose veins of lower limbs. , 1998, Molecular genetics and metabolism.

[37]  D. Milewicz,et al.  Fibrillin–2 (FBN2) mutations result in the Marfan–like disorder, congenital contractural arachnodactyly , 1995, Nature Genetics.

[38]  W. Lamorte,et al.  Risk factors for chronic venous insufficiency: a dual case-control study. , 1995, Journal of vascular surgery.

[39]  A. Reunanen,et al.  Prevalence and risk factors of varicose veins in lower extremities: mini-Finland health survey. , 1995, The European journal of surgery = Acta chirurgica.

[40]  I. de Vincenzi,et al.  Importance of the familial factor in varicose disease. Clinical study of 134 families. , 1994, The Journal of dermatologic surgery and oncology.

[41]  S. Komşuoğlu,et al.  Prevalence and risk factors of varicose veins in an elderly population. , 1994, Gerontology.

[42]  S. Fukuda,et al.  Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases. , 1992, The Journal of clinical investigation.

[43]  M. Hirai,et al.  Prevalence and Risk Factors of Varicose Veins in Japanese Women , 1990, Angiology.

[44]  A L Dannenberg,et al.  The epidemiology of varicose veins: the Framingham Study. , 1988, American journal of preventive medicine.

[45]  J. Abramson,et al.  The epidemiology of varicose veins. A survey in western Jerusalem. , 1981, Journal of epidemiology and community health.

[46]  S. Malhotra An epidemiological study of varicose veins in Indian railroad workers from the South and North of India, with special reference to the causation and prevention of varicose veins. , 1972, International journal of epidemiology.