Viruses in asthma exacerbations

Purpose of review Respiratory viruses are well recognized as major triggers of acute exacerbations of asthma in children and adults, resulting in frequent outpatients visits and hospitalizations. Clinical and epidemiologic evidence supports this association. The application of molecular diagnostic methods has improved understanding of viral epidemiology and the pathophysiological mechanisms involved in viral induced acute asthma. This article reviews publications since October 2002 for an update of the role of viruses in exacerbations of asthma. Recent findings Respiratory viruses are present in most patients hospitalized for life-threatening asthma and acute nonlife-threatening asthma. Rhinovirus is the most common, but coinfection with other viruses may be important. Patients with asthma are not more susceptible to upper respiratory tract rhinovirus infections than healthy people but suffer from more severe consequences of the lower respiratory tract infection. Recent epidemiologic studies suggest that viruses provoke asthma attacks by additive or synergistic interactions with allergen exposure or with air pollution. An impaired antiviral immunity to rhinovirus may lead to impaired viral clearance and hence prolonged symptoms. Respiratory viral infections cause asthmatic exacerbations by triggering recruitment of Th2-type cells into the lungs. There is no specific antiviral strategy for prevention of respiratory-triggered asthma exacerbations, although clinical trials of potential antiviral agents are ongoing. Indirect prevention strategies focus on the reduction of overall airway inflammation to reduce the severity of the host response to respiratory viral infections. Summary Respiratory viral infections are a major cause of morbidity and mortality in asthma. There is a lack of specific antiviral strategies in the prevention or reduction of viral-triggered asthma exacerbations. Recent advances in understanding of the epidemiology and immunopathogenesis of respiratory viral infection in asthma provide opportunities or identification of specific targets for antiviral agents and strategies for management and prevention.

[1]  R. Wood,et al.  EARLY INTERVENTION WITH BUDESONIDE IN MILD PERSISTENT ASTHMA: A RANDOMIZED, DOUBLE-BLIND TRIAL , 2004, Pediatrics.

[2]  N. Papadopoulos,et al.  Expression of Costimulatory Molecules in Peripheral Blood Mononuclear Cells of Atopic Asthmatic Children during Virus-Induced Asthma Exacerbations , 2004, International Archives of Allergy and Immunology.

[3]  J. Schwarze,et al.  Enhanced virulence, airway inflammation and impaired lung function induced by respiratory syncytial virus deficient in secreted G protein , 2004, Thorax.

[4]  S. Watanabe,et al.  Double‐stranded RNA activates RANTES gene transcription through co‐operation of nuclear factor‐κB and interferon regulatory factors in human airway epithelial cells , 2004 .

[5]  S. Permutt,et al.  Role of nasal nitric oxide in the resolution of experimental rhinovirus infection. , 2004, The Journal of allergy and clinical immunology.

[6]  M. Chapman,et al.  Risk factors for wheezing in a subtropical environment , 2004, Journal of Allergy and Clinical Immunology.

[7]  Siep Thomas,et al.  Influenza vaccination in children with asthma: randomized double-blind placebo-controlled trial. , 2004, American journal of respiratory and critical care medicine.

[8]  S. Johnston.  Experimental models of rhinovirus-induced exacerbations of asthma: where to now? , 2003, American journal of respiratory and critical care medicine.

[9]  K. Rabe,et al.  Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure? , 2003, American journal of respiratory and critical care medicine.

[10]  W. Busse,et al.  Rhinovirus-induced Interferon-γ and Airway Responsiveness in Asthma , 2003 .

[11]  E. D. de KLERK,et al.  Interleukin‐1β and interleukin‐1ra levels in nasal lavages during experimental rhinovirus infection in asthmatic and non‐asthmatic subjects , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[12]  S. Johnston,et al.  Host defense function of the airway epithelium in health and disease: clinical background , 2003, Journal of leukocyte biology.

[13]  R. Hegele,et al.  Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. , 2003, The American journal of medicine.

[14]  P. Nibbering,et al.  Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells. , 2003, FEMS immunology and medical microbiology.

[15]  N. Wilson.  Virus infections, wheeze and asthma , 2003, Paediatric Respiratory Reviews.

[16]  S. Johnston,et al.  Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children , 2003, The Lancet.

[17]  S. Holgate,et al.  Rhinovirus is not detectable in peripheral lung tissue after asthma death , 2003, Respirology.

[18]  A. Anzueto,et al.  Diagnosis and treatment of rhinovirus respiratory infections. , 2003, Chest.

[19]  F. Hayden,et al.  Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgE. , 2003, The Journal of allergy and clinical immunology.

[20]  J. Morton,et al.  Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection. , 2003, The Journal of infectious diseases.

[21]  K. Yeatts,et al.  Presence of asthma risk factors and environmental exposures related to upper respiratory infection-triggered wheezing in middle school-age children. , 2003, Environmental Health Perspectives.

[22]  Marilyn Halonen,et al.  Tucson Children's Respiratory Study: 1980 to present. , 2003, The Journal of allergy and clinical immunology.

[23]  William W Busse,et al.  Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial , 2003, The Lancet.

[24]  R. Lemanske.  Is asthma an infectious disease?: Thomas A. Neff lecture. , 2003, Chest.

[25]  S. Greenberg.  Respiratory consequences of rhinovirus infection. , 2003, Archives of internal medicine.

[26]  M. Weinberger.  Treatment strategies for viral respiratory infection-induced asthma. , 2003, The Journal of pediatrics.

[27]  J. Gern.  Mechanisms of virus-induced asthma. , 2003, The Journal of pediatrics.

[28]  H. Bisgaard.  A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. , 2003, American journal of respiratory and critical care medicine.

[29]  N. Papadopoulos,et al.  The role of respiratory viruses in the origin and exacerbations of asthma , 2003, Current opinion in allergy and clinical immunology.

[30]  D. Turck,et al.  Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: A prospective study in the Nord‐Pas de Calais region (France) , 2003, Pediatric pulmonology.

[31]  S. Osur.  Viral respiratory infections in association with asthma and sinusitis: a review. , 2002, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[32]  D. Chaplin,et al.  Antigen-Nonspecific Recruitment of Th2 Cells to the Lung as a Mechanism for Viral Infection-Induced Allergic Asthma1 , 2002, The Journal of Immunology.

[33]  J. Gern.  Rhinovirus respiratory infections and asthma. , 2002, The American journal of medicine.

[34]  N. Papadopoulos,et al.  A defective type 1 response to rhinovirus in atopic asthma , 2002, Thorax.

[35]  H. Donninger,et al.  Rhinovirus Is Associated with Severe Asthma Exacerbations and Raised Nasal Interleukin-12 , 2002, Respiration.

[36]  Stephen T Holgate,et al.  Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study , 2002, The Lancet.

[37]  Kwai Peng Chan,et al.  Comparison of three methods for respiratory virus detection between induced sputum and nasopharyngeal aspirate specimens in acute asthma. , 2002, Journal of virological methods.

[38]  N. Papadopoulos,et al.  Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells. , 2001, The Journal of allergy and clinical immunology.

[39]  J. V. van Krieken,et al.  Experimental rhinovirus 16 infection increases intercellular adhesion molecule‐1 expression in bronchial epithelium of asthmatics regardless of inhaled steroid treatment , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[40]  J. Abisheganaden,et al.  Effects of allergic inflammation of the nasal mucosa on the severity of rhinovirus 16 cold. , 2000, The Journal of allergy and clinical immunology.

[41]  R. Davis,et al.  Influenza vaccination in children with asthma in health maintenance organizations. Vaccine Safety Datalink Team. , 2000, Vaccine.

[42]  T. Jefferson,et al.  Vaccines for preventing influenza in people with asthma (Cochrane Review). , 2000, The Cochrane database of systematic reviews.

[43]  E. D. de KLERK,et al.  Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. , 1999, American journal of respiratory and critical care medicine.

[44]  F. Hayden,et al.  Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. , 1999, American journal of respiratory and critical care medicine.

[45]  M. Sears.  Epidemiology of childhood asthma , 1997, The Lancet.

[46]  H. Teichtahl,et al.  The Incidence of Respiratory Tract Infection in Adults Requiring Hospitalization for Asthma , 1997, Chest.

[47]  G. Marks,et al.  Are non‐allergenic environmental factors important in asthma? , 1995, The Medical journal of Australia.

[48]  Stephen T Holgate,et al.  Community study of role of viral infections in exacerbations of asthma in 9-11 year old children , 1995, BMJ.

[49]  K. Nicholson,et al.  Respiratory viruses and exacerbations of asthma in adults. , 1993, BMJ.

[50]  M. Burr.  Epidemiology of childhood asthma. , 1991, Allergie et immunologie.

[51]  G. M. Stokes,et al.  Lung function abnormalities after acute bronchiolitis. , 1981, The Journal of pediatrics.

[52]  L. Arruda.  Risk factors for wheezing in a subtropical environment: role of respiratory viruses and allergen sensitization , 2006 .

[53]  M. Kawaguchi,et al.  Double-stranded RNA activates RANTES gene transcription through co-operation of nuclear factor-kappaB and interferon regulatory factors in human airway epithelial cells. , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[54]  W. Busse,et al.  Rhinovirus-induced interferon-gamma and airway responsiveness in asthma. , 2003, American journal of respiratory and critical care medicine.

[55]  Hidetada Sasaki,et al.  Rhinovirus and asthma. , 2003, Viral immunology.

[56]  R. Hegele,et al.  PCR detection of viral nucleic acid in fatal asthma: is the lower respiratory tract a reservoir for common viruses? , 1999, Canadian respiratory journal.