Can we distinguish chronic myeloid leukemia presenting in the lymphoblastic phase from de novo Philadelphia-positive acute lymphoid leukemia?

abnormality myeloid leukemia also in 25% of patients Ph translocation results from fusion of BCR at 22q11.2 with ABL1 at 9q34, result-ing in production of a BCR-ABL fusion protein. Two princi-pal forms of the protein, p190 Kd and p210 Kd, from distinct breakpoints in the BCR gene. In adults, about 50% of Ph+ALL cases produce the p210 fusion protein, which is present in more than 95% of CML cases, and the remainder produce the p190 protein. CML progresses to the blastic phase if it is left untreated, without a bone marrow transplantation or administration of a tyrosine kinase inhibi-tor. The blasts in the majority of patients in the blastic phase be of the myeloid lineage; approximately 20-30% of the are lymphoblasts. of patients in the blastic phase a chronic phase. of chronic phase lymphoblastic the lymphoblastic phase