Avaliação qualitativa e quantitativa das lesões agudas por esmagamento do nervo isquiático do rato

Rats’ ischiatic nerves smashed with different loads were studied with the aid of light microscopy. Weights of 500 g, 1,000 g, 5,000 g, 10,000 g, and 15,000 g were used for 10 minutes in a portable device, especially developed for this study. Morphological and morphometrical analyses of myelinic fibers showed that the injury produced on neural fibers and on neural tissue was directly proportional to the load applied and that a load of 500 g is enough to produce a severe damage, with an important injury of endoneural structures.

[1]  N. Mazzer,et al.  Can therapeutic ultrasound influence the regeneration of peripheral nerves? , 2005, Journal of Neuroscience Methods.

[2]  Douglas W. Losordo,et al.  Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves , 2004, Neurobiology of Aging.

[3]  N. Mazzer,et al.  The end-to-side peripheral nerve repair Functional and morphometric study using the peroneal nerve of rats , 2004, Journal of Neuroscience Methods.

[4]  N. Mazzer,et al.  The use of a muscle graft to repair a segmentary nerve defect An experimental study using the sciatic nerve of rats as model , 2004, Journal of Neuroscience Methods.

[5]  M. Aktekin,et al.  Effect of trapidil on the sciatic nerve with crush injury: a light microscopic study , 2004 .

[6]  Adriana Clemente Mendonça,et al.  Directly applied low intensity direct electric current enhances peripheral nerve regeneration in rats , 2003, Journal of Neuroscience Methods.

[7]  G. Beer,et al.  Standardizing Nerve Crushes with a Non-Serrated Clamp , 2001, Journal of reconstructive microsurgery.

[8]  N. Mazzer,et al.  Correlation between functional index and morphometry to evaluate recovery of the rat sciatic nerve following crush injury: experimental study. , 2001, Journal of reconstructive microsurgery.

[9]  Y. Hirasawa,et al.  Ultrastructural Characteristics and Synaptophysin Immunohistochemistry of Regenerating Nerve Growth Cones Following Traumatic Injury to Rat Peripheral Nerve , 2000, Journal of reconstructive microsurgery.

[10]  S. Mackinnon,et al.  FK506 promotes functional recovery in crushed rat sciatic nerve , 2000, Muscle & nerve.

[11]  Fazan,et al.  Morphology of aortic depressor nerve myelinated fibers in normotensive Wistar-Kyoto and spontaneously hypertensive rats. , 1999, Journal of the autonomic nervous system.

[12]  A. Seaber,et al.  Functional effects of lymphotoxin on crushed peripheral nerve , 1996, Microsurgery.

[13]  S. Mackinnon,et al.  Nerve Crush Injuries—A Model for Axonotmesis , 1994, Experimental Neurology.

[14]  A. Seaber,et al.  The functional recovery of peripheral nerves following defined acute crush injuries , 1992, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[15]  M. Tonoike,et al.  Simultaneous recording of [Ca2+]i increases in isolated olfactory receptor neurons retaining their original spatial relationship in intact tissue , 1992, Journal of Neuroscience Methods.

[16]  G. Lundborg,et al.  Nerve compression injury and increased endoneurial fluid pressure: a "miniature compartment syndrome". , 1983, Journal of neurology, neurosurgery, and psychiatry.

[17]  W. Freed,et al.  An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks , 1982, Experimental Neurology.