Changes in endothelium‐derived hyperpolarizing factor in hypertension and ageing: response to chronic treatment with renin–angiotensin system inhibitors

1. Endothelial function is impaired in hypertension and ageing and this may be associated with an increase in cardiovascular disease. Several clinical studies have shown that blocking the renin–angiotensin system (RAS) improves endothelial function not only in hypertensive patients, but also in normotensive patients with cardiovascular disease.

[1]  R. Busse,et al.  Aged Spontaneously Hypertensive Rats Exhibit a Selective Loss of EDHF-Mediated Relaxation in the Renal Artery , 2003, Hypertension.

[2]  Karl Swedberg,et al.  Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial , 2003, The Lancet.

[3]  C. Hill,et al.  Structure, Function, and Endothelium-Derived Hyperpolarizing Factor in the Caudal Artery of the SHR and WKY Rat , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[4]  E. Schiffrin,et al.  Beyond blood pressure: the endothelium and atherosclerosis progression. , 2002, American journal of hypertension.

[5]  A. Quyyumi,et al.  Prognostic Value of Coronary Vascular Endothelial Dysfunction , 2002, Circulation.

[6]  R. Hainsworth,et al.  Change in endothelial function in mesenteric arteries of sprague‐dawley rats fed a high salt diet , 2002, The Journal of physiology.

[7]  R. Busse,et al.  EDHF: bringing the concepts together. , 2002, Trends in pharmacological sciences.

[8]  M. Iida,et al.  Critical Role Of Gap Junctions In Endothelium‐Dependent Hyperpolarization In Rat Mesenteric Arteries , 2002, Clinical and experimental pharmacology & physiology.

[9]  H. Coleman,et al.  Involvement of Myoendothelial Gap Junctions in the Actions of Endothelium-Derived Hyperpolarizing Factor , 2002, Circulation research.

[10]  W. Campbell,et al.  What is new in endothelium-derived hyperpolarizing factors? , 2002, Current opinion in nephrology and hypertension.

[11]  M. Iida,et al.  Angiotensin II receptor antagonist improves age-related endothelial dysfunction , 2002, Journal of hypertension.

[12]  J. Whitworth,et al.  Decreased endothelial size and connexin expression in rat caudal arteries during hypertension , 2002, Journal of hypertension.

[13]  C. Triggle,et al.  Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s). , 2001, Canadian journal of physiology and pharmacology.

[14]  J. Phillips,et al.  Heterogeneous control of blood flow amongst different vascular beds , 2001, Medicinal research reviews.

[15]  M. Fujishima,et al.  Renin-Angiotensin System Blockade Improves Endothelial Dysfunction in Hypertension , 2000, Hypertension.

[16]  M. Fujishima,et al.  Angiotensin-Converting Enzyme Inhibitor Prevents Age-Related Endothelial Dysfunction , 2000, Hypertension.

[17]  S. Yusuf,et al.  Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. , 1999, Circulation.

[18]  M. Kähönen,et al.  Losartan and enalapril therapies enhance vasodilatation in the mesenteric artery of spontaneously hypertensive rats. , 1999, European journal of pharmacology.

[19]  S. Tanaka,et al.  Endothelium‐derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats , 1999, British journal of pharmacology.

[20]  H. Matsubara,et al.  Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. , 1998, Circulation research.

[21]  M. Fujishima,et al.  Antihypertensive treatment improves endothelium-dependent hyperpolarization in the mesenteric artery of spontaneously hypertensive rats. , 1998, Circulation.

[22]  A. Takeshita,et al.  Importance of endothelium-derived hyperpolarizing factor in human arteries. , 1997, The Journal of clinical investigation.

[23]  J. Swales.  Clinical trials: what more is needed? A critical view , 1996, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[24]  D. Ganten,et al.  Chymase-dependent angiotensin II forming systems in humans. , 1996, American journal of hypertension.

[25]  F. Ledda,et al.  Roles of Nitric Oxide and Endothelium‐Derived Hyperpolarizing Factor in Vasorelaxant Effect of Acetylcholine as Influenced by Aging and Hypertension , 1995, Journal of cardiovascular pharmacology.

[26]  T. Wascher,et al.  Endothelial dysfunction in hypertension , 1994, The Lancet.

[27]  A. A. Taylor,et al.  Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries. , 1993, The Journal of clinical investigation.

[28]  M. Fujishima,et al.  Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. , 1993, The American journal of physiology.

[29]  M. Fujishima,et al.  Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats. , 1992, Circulation research.

[30]  H. Suzuki,et al.  Endothelium-Derived Hyperpolarizing Factor (EDHF): An Endogenous Potassium-Channel Activator , 1990 .

[31]  M. Gimbrone.  Endothelial Dysfunction and Atherosclerosis , 1989, Journal of cardiac surgery.

[32]  R. Andriantsitohaina,et al.  Age-related endothelial dysfunction : potential implications for pharmacotherapy. , 2003, Drugs & aging.

[33]  L. Ghiadoni,et al.  Effects of antihypertensive drugs on endothelial dysfunction: clinical implications. , 2002, Drugs.

[34]  I. Leusen,et al.  Endothelium-dependent relaxation and hyperpolarization in aorta from control and renal hypertensive rats. , 1992, Circulation research.